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ExpreS2ion Biotech Holding ABOSTO:EXPRS2 +1.46%43 Cyclically Adjusted PB Ratio is 0.07 as of Jul. 22, 2026, which is 75% below its 10-year median of 0.28. GuruFocus rates OSTO:EXPRS2 with a GF Score™ of 43/100 and a GF Value™ of kr3.42 (Possible Value Trap). The stock has 5 warning signs investors should review. Among 698 Biotechnology companies, ExpreS2ion Biotech Holding AB ranks better than 91.4% on this metric.
The historical rank and industry rank for ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio or its related term are showing as below:
OSTO:EXPRS2'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.07 Med: 0.28 Max: 0.5
Current: 0.07
During the past years, ExpreS2ion Biotech Holding AB's highest Cyclically Adjusted PB Ratio was 0.50. The lowest was 0.07. And the median was 0.28.
OSTO:EXPRS2's Cyclically Adjusted PB Ratio is ranked better than 91.4% of 698
companies
in the Biotechnology industry
Industry Median: 1.595
vs OSTO:EXPRS2: 0.07
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
ExpreS2ion Biotech Holding AB's adjusted book value per share data for the three months ended in Mar. 2026 was kr2.673. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is kr20.44 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
ExpreS2ion Biotech Holding AB (OSTO:EXPRS2) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
ExpreS2ion Biotech Holding AB Cyclically Adjusted PB Ratio Related Terms
ExpreS2ion Biotech Holding AB Cyclically Adjusted PB Ratio Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ExpreS2ion Biotech Holding AB Cyclically Adjusted PB Ratio Chart
OSTO:EXPRS2 vs VRTX, REGN, ALNY: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
ExpreS2ion Biotech Holding AB Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio falls into.
ExpreS2ion Biotech Holding AB Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 0.07 mean?
ExpreS2ion Biotech Holding AB (OSTO:EXPRS2) has a Cyclically Adjusted PB Ratio of 0.07 as of Jul. 22, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on ExpreS2ion Biotech Holding AB and its competitors. This is 75% below median its historical median of 0.28. Over the past decade, ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio has ranged from 0.07 to 0.50. According to the industry distribution chart, ExpreS2ion Biotech Holding AB ranks #60 out of 698 companies in the Biotechnology industry, placing it in the top 8.6%.
Is ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio too high?
ExpreS2ion Biotech Holding AB's current Cyclically Adjusted PB Ratio of 0.07 is 75% below median its 10-year median of 0.28. Over the past 10 years, this metric has ranged from a low of 0.07 to a high of 0.50. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.60. ExpreS2ion Biotech Holding AB's value of 0.07 is 95.6% below this industry median. Based on the distribution chart, ExpreS2ion Biotech Holding AB ranks #60 out of 698 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, ExpreS2ion Biotech Holding AB has a GF Score™ of 43/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does ExpreS2ion Biotech Holding AB's Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, ExpreS2ion Biotech Holding AB ranks #60 out of 698 companies for Cyclically Adjusted PB Ratio. This places ExpreS2ion Biotech Holding AB in the top 9% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.60. ExpreS2ion Biotech Holding AB's value of 0.07 is 95.6% below this benchmark. Historically, ExpreS2ion Biotech Holding AB's own Cyclically Adjusted PB Ratio has ranged from 0.07 to 0.50 over the past decade. While the company's 10-year median is 0.28 vs. the industry median of 1.60, ExpreS2ion Biotech Holding AB has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.60, based on 698 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. ExpreS2ion Biotech Holding AB's current Cyclically Adjusted PB Ratio of 0.07 is 95.6% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on ExpreS2ion Biotech Holding AB and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.60 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. ExpreS2ion Biotech Holding AB's current Cyclically Adjusted PB Ratio is 0.07, which is 75% below median its own 10-year median of 0.28. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ExpreS2ion Biotech Holding AB stock overvalued right now?
Based on GuruFocus' analysis, ExpreS2ion Biotech Holding AB (OSTO:EXPRS2) is currently considered Possible Value Trap. The stock's GF Value™ is kr3.42, compared to a current price of kr1.39 — trading 59.4% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.07, which is 75% below median its 10-year median of 0.28 and 95.6% below the Biotechnology industry median of 1.60. ExpreS2ion Biotech Holding AB's overall GF Score™ is 43/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For ExpreS2ion Biotech Holding AB (OSTO:EXPRS2), the current Cyclically Adjusted PB Ratio is 0.07 as of Jul. 22, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is ExpreS2ion Biotech Holding AB (OSTO:EXPRS2) Overvalued in 2026?
Based on GuruFocus' analysis, ExpreS2ion Biotech Holding AB stock appears to be undervalued.
The current stock price of kr1.39 is trading 59.4% below its estimated GF Value™ of kr3.42.
GuruFocus considers ExpreS2ion Biotech Holding AB to be Possible Value Trap.
Key valuation signals for OSTO:EXPRS2:
Cyclically Adjusted PB Ratio: 0.07 (75% below median its 10-year median of 0.28)
GF Value™: kr3.42 vs. price of kr1.39 (59.4% below fair value)
Industry Position: 95.6% below the Biotechnology median (#60 of 698)
No single metric tells the full story. See the OSTO:EXPRS2 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
ExpreS2ion Biotech Holding AB Business Description
ExpreS2ion Biotech Holding AB is a biotechnology company that develops vaccines. It has developed a human clinical Phase III-validated technology platform, ExpreS2, for fast and efficient development and production of the active material in vaccines. The platform, under the brand GlycoX-S2, includes functionally modified glycosylation variants for enhanced immunogenicity and pharmacokinetics. Its product pipeline comprises ES2B-C001, a HER2-VLP-based vaccine in development for human breast cancer therapy and several exploratory vaccine projects targeting pathways validated by commercial monoclonal antibody products. Geographically, the company operates in the Nordics region and also has a presence in other countries.
43GF Score
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