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Astellas PharmaTSE:4503 -0.30%75 Cyclically Adjusted PB Ratio is 2.76 as of Aug. 13, 2026, which is 1% below its 10-year median of 2.78. GuruFocus rates TSE:4503 with a GF Score™ of 75/100 and a GF Value™ of 円2,306.53 (Fairly Valued). The stock has 5 warning signs investors should review. Among 729 Drug Manufacturers companies, Astellas Pharma ranks worse than 66.12% on this metric.
The historical rank and industry rank for Astellas Pharma's Cyclically Adjusted PB Ratio or its related term are showing as below:
TSE:4503'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 1.58 Med: 2.78 Max: 3.62
Current: 2.77
During the past years, Astellas Pharma's highest Cyclically Adjusted PB Ratio was 3.62. The lowest was 1.58. And the median was 2.78.
TSE:4503's Cyclically Adjusted PB Ratio is ranked worse than 66.12% of 729
companies
in the Drug Manufacturers industry
Industry Median: 1.8
vs TSE:4503: 2.77
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Astellas Pharma's adjusted book value per share data for the three months ended in Jun. 2026 was 円1,083.475. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円853.77 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Astellas Pharma (TSE:4503) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Astellas Pharma Cyclically Adjusted PB Ratio Related Terms
Astellas Pharma Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Astellas Pharma's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Astellas Pharma Cyclically Adjusted PB Ratio Chart
TSE:4503 vs LLY, JNJ, ABBV: Cyclically Adjusted PB Ratio Comparison
For the Drug Manufacturers - General subindustry, Astellas Pharma's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Astellas Pharma Cyclically Adjusted PB Ratio vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, Astellas Pharma's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Astellas Pharma's Cyclically Adjusted PB Ratio falls into.
Astellas Pharma Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Astellas Pharma's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 2.76 mean?
Astellas Pharma (TSE:4503) has a Cyclically Adjusted PB Ratio of 2.76 as of Aug. 13, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Astellas Pharma and its competitors. This is near median its historical median of 2.78. Over the past decade, Astellas Pharma's Cyclically Adjusted PB Ratio has ranged from 1.58 to 3.62. According to the industry distribution chart, Astellas Pharma ranks #482 out of 729 companies in the Drug Manufacturers industry, placing it in the top 66.1%.
Is Astellas Pharma's Cyclically Adjusted PB Ratio too high?
Astellas Pharma's current Cyclically Adjusted PB Ratio of 2.76 is near median its 10-year median of 2.78. Over the past 10 years, this metric has ranged from a low of 1.58 to a high of 3.62. The Drug Manufacturers industry median Cyclically Adjusted PB Ratio is 1.80. Astellas Pharma's value of 2.76 is 53.3% above this industry median. Based on the distribution chart, Astellas Pharma ranks #482 out of 729 companies in the Drug Manufacturers industry, which is below the industry midpoint. Overall, Astellas Pharma has a GF Score™ of 75/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Astellas Pharma's Cyclically Adjusted PB Ratio compare to LLY and JNJ?
According to the Drug Manufacturers industry distribution chart, Astellas Pharma ranks #482 out of 729 companies for Cyclically Adjusted PB Ratio. This places Astellas Pharma in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.80. Astellas Pharma's value of 2.76 is 53.3% above this benchmark. Historically, Astellas Pharma's own Cyclically Adjusted PB Ratio has ranged from 1.58 to 3.62 over the past decade. While the company's 10-year median is 2.78 vs. the industry median of 1.80, Astellas Pharma has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Drug Manufacturers company?
The median Cyclically Adjusted PB Ratio among Drug Manufacturers companies is 1.80, based on 729 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Astellas Pharma's current Cyclically Adjusted PB Ratio of 2.76 is 53.3% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Astellas Pharma and its competitors. For the Drug Manufacturers industry, the median Cyclically Adjusted PB Ratio is 1.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Astellas Pharma's current Cyclically Adjusted PB Ratio is 2.76, which is near median its own 10-year median of 2.78. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Astellas Pharma stock overvalued right now?
Based on GuruFocus' analysis, Astellas Pharma (TSE:4503) is currently considered Fairly Valued. The stock's GF Value™ is 円2,306.53, compared to a current price of 円2,356.00 — trading 2.1% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 2.76, which is near median its 10-year median of 2.78 and 53.3% above the Drug Manufacturers industry median of 1.80. Astellas Pharma's overall GF Score™ is 75/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Astellas Pharma (TSE:4503), the current Cyclically Adjusted PB Ratio is 2.76 as of Aug. 13, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Astellas Pharma (TSE:4503) Overvalued in 2026?
Based on GuruFocus' analysis, Astellas Pharma stock appears to be overvalued.
The current stock price of 円2,356.00 is trading 2.1% above its estimated GF Value™ of 円2,306.53.
GuruFocus considers Astellas Pharma to be Fairly Valued.
Key valuation signals for TSE:4503:
Cyclically Adjusted PB Ratio: 2.76 (near median its 10-year median of 2.78)
GF Value™: 円2,306.53 vs. price of 円2,356.00 (2.1% above fair value)
Industry Position: 53.3% above the Drug Manufacturers median (#482 of 729)
No single metric tells the full story. See the TSE:4503 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Astellas Pharma Inc is a specialty international pharmaceutical company. The company focuses on accelerating the discovery, development, and commercialization of ground-breaking innovations that could redefine expectations of care for difficult-to-treat diseases. The group is committed to driving innovation in immuno-oncology, gene therapy, mitochondria, blindness and regeneration, and targeted protein degradation. Its core products include anticancer agents like XTANDI, XOSPATA, and PADCEV; VEOZAH for the treatment of vasomotor symptoms due to menopause; Betanis / Myrbetriq / BETMIGA for the treatment of overactive bladder (OAB); and Prograf, an immunosuppressant for organ transplantation.
75GF Score
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