OPKO Health (XTAE:OPK) Cyclically Adjusted PB Ratio: 0.53 (As of Sep. 08, 2026) — 45% Below Median

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XTAE:OPK OPKO Health Inc XTAE:OPK
53 GF Score
Price ₪4.80
GF Value ₪3.31
Valuation Significantly Overvalued
! 8 Warning Signs
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What is OPKO Health Cyclically Adjusted PB Ratio?

OPKO Health XTAE:OPK -1.50% 53 Cyclically Adjusted PB Ratio is 0.53 as of Sep. 08, 2026, which is 45% below its 10-year median of 0.97. GuruFocus rates XTAE:OPK with a GF Score™ of 53/100 and a GF Value™ of ₪3.31 (Significantly Overvalued). The stock has 8 warning signs investors should review. Among 127 Medical Diagnostics & Research companies, OPKO Health ranks better than 77.95% on this metric.

As of today (2026-09-08), OPKO Health's current share price is ₪4.799. OPKO Health's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 was ₪9.12. OPKO Health's Cyclically Adjusted PB Ratio for today is 0.53.

The historical rank and industry rank for OPKO Health's Cyclically Adjusted PB Ratio or its related term are showing as below:

XTAE:OPK' s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.27   Med: 0.97   Max: 11.32
Current: 0.54

During the past years, OPKO Health's highest Cyclically Adjusted PB Ratio was 11.32. The lowest was 0.27. And the median was 0.97.

XTAE:OPK's Cyclically Adjusted PB Ratio is ranked better than
77.95% of 127 companies
in the Medical Diagnostics & Research industry
Industry Median: 1.82 vs XTAE:OPK: 0.54

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

OPKO Health's adjusted book value per share data for the three months ended in Jun. 2026 was ₪4.782. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is ₪9.12 for the trailing ten years ended in Jun. 2026.

Shiller PE for Stocks: The True Measure of Stock Valuation

OPKO Health  (XTAE:OPK) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.

OPKO Health Cyclically Adjusted PB Ratio Related Terms

OPKO Health Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for OPKO Health's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health Cyclically Adjusted PB Ratio Chart

OPKO Health Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 1.71 0.40 0.47 0.45 0.40

OPKO Health Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.40 0.48 0.40 0.36 0.49

XTAE:OPK vs CSTL, FRNM, FLGT: Cyclically Adjusted PB Ratio Comparison

For the Diagnostics & Research subindustry, OPKO Health's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

OPKO Health Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where OPKO Health's Cyclically Adjusted PB Ratio falls into.


XTAE:OPK
53GF Score
OPKO Health Inc XTAE:OPK
Cyclically Adjusted PB Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

OPKO Health Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

OPKO Health's Cyclically Adjusted PB Ratio for today is calculated as

Cyclically Adjusted PB Ratio=Share Price/ Cyclically Adjusted Book per Share
=4.799/9.12
=0.53

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 is calculated as:

For example, OPKO Health's adjusted Book Value per Share data for the three months ended in Jun. 2026 was:

Adj_Book=Book Value per Share/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=4.782/333.9520*333.9520
=4.782

Current CPI (Jun. 2026) = 333.9520.

OPKO Health Quarterly Data

Book Value per Share CPI Adj_Book
201609 11.376 241.428 15.736
201612 11.292 241.432 15.619
201703 11.354 243.801 15.552
201706 11.345 244.955 15.467
201709 11.249 246.819 15.220
201712 9.926 246.524 13.446
201803 9.817 249.554 13.137
201806 9.745 251.989 12.915
201809 9.624 252.439 12.732
201812 9.203 251.233 12.233
201903 8.625 254.202 11.331
201906 8.362 256.143 10.902
201909 8.034 256.759 10.449
201912 7.262 256.974 9.437
202003 6.964 258.115 9.010
202006 7.143 257.797 9.253
202009 7.300 260.280 9.366
202012 7.509 260.474 9.627
202103 7.626 264.877 9.615
202106 7.706 271.696 9.472
202109 7.806 274.310 9.503
202112 7.449 278.802 8.922
202203 7.138 287.504 8.291
202206 6.707 296.311 7.559
202209 6.351 296.808 7.146
202212 6.088 296.797 6.850
202303 6.050 301.836 6.694
202306 5.983 305.109 6.549
202309 5.629 307.789 6.107
202312 5.412 306.746 5.892
202403 5.414 312.332 5.789
202406 6.027 314.175 6.406
202409 6.194 315.301 6.560
202412 6.125 315.605 6.481
202503 5.883 319.799 6.143
202506 5.010 322.561 5.187
202509 5.116 324.800 5.260
202512 5.032 324.054 5.186
202603 4.806 330.213 4.860
202606 4.782 333.952 4.782

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

What does a Cyclically Adjusted PB Ratio of 0.53 mean?
OPKO Health (XTAE:OPK) has a Cyclically Adjusted PB Ratio of 0.53 as of Sep. 08, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors. This is 45% below median its historical median of 0.97. Over the past decade, OPKO Health's Cyclically Adjusted PB Ratio has ranged from 0.27 to 11.32. According to the industry distribution chart, OPKO Health ranks #28 out of 127 companies in the Medical Diagnostics & Research industry, placing it in the top 22%.
Is OPKO Health's Cyclically Adjusted PB Ratio too high?
OPKO Health's current Cyclically Adjusted PB Ratio of 0.53 is 45% below median its 10-year median of 0.97. Over the past 10 years, this metric has ranged from a low of 0.27 to a high of 11.32. The Medical Diagnostics & Research industry median Cyclically Adjusted PB Ratio is 1.82. OPKO Health's value of 0.53 is 70.9% below this industry median. Based on the distribution chart, OPKO Health ranks #28 out of 127 companies in the Medical Diagnostics & Research industry, which is in the top quartile — a strong position relative to peers. Overall, OPKO Health has a GF Score™ of 53/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OPKO Health's Cyclically Adjusted PB Ratio compare to CSTL and FRNM?
According to the Medical Diagnostics & Research industry distribution chart, OPKO Health ranks #28 out of 127 companies for Cyclically Adjusted PB Ratio. This places OPKO Health in the top 22% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.82. OPKO Health's value of 0.53 is 70.9% below this benchmark. Historically, OPKO Health's own Cyclically Adjusted PB Ratio has ranged from 0.27 to 11.32 over the past decade. While the company's 10-year median is 0.97 vs. the industry median of 1.82, OPKO Health has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Medical Diagnostics & Research company?
The median Cyclically Adjusted PB Ratio among Medical Diagnostics & Research companies is 1.82, based on 127 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. OPKO Health's current Cyclically Adjusted PB Ratio of 0.53 is 70.9% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors. For the Medical Diagnostics & Research industry, the median Cyclically Adjusted PB Ratio is 1.82 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. OPKO Health's current Cyclically Adjusted PB Ratio is 0.53, which is 45% below median its own 10-year median of 0.97. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OPKO Health stock overvalued right now?
Based on GuruFocus' analysis, OPKO Health (XTAE:OPK) is currently considered Significantly Overvalued. The stock's GF Value™ is ₪3.31, compared to a current price of ₪4.80 — trading 45% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.53, which is 45% below median its 10-year median of 0.97 and 70.9% below the Medical Diagnostics & Research industry median of 1.82. OPKO Health's overall GF Score™ is 53/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For OPKO Health (XTAE:OPK), the current Cyclically Adjusted PB Ratio is 0.53 as of Sep. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OPKO Health (XTAE:OPK) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of ₪4.80 is trading 45% above its estimated GF Value™ of ₪3.31. GuruFocus considers OPKO Health to be Significantly Overvalued.

Key valuation signals for XTAE:OPK:

  • Cyclically Adjusted PB Ratio: 0.53 (45% below median its 10-year median of 0.97)
  • GF Value™: ₪3.31 vs. price of ₪4.80 (45% above fair value)
  • GF Score™: 53/100 with 8 warning signs
  • Industry Position: 70.9% below the Medical Diagnostics & Research median (#28 of 127)

No single metric tells the full story. See the XTAE:OPK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.

OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
53GF Score

Get the complete analysis for XTAE:OPK

Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

₪4.80
Price
₪3.31
GF Value