Synlogic (LTS:0A8U) Cyclically Adjusted PS Ratio: (As of Aug. 21, 2026)

Author: Vera Yuan Vera Yuan
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Director of Data and Quant Analytics at GuruFocus
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Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

LTS:0A8U Synlogic Inc LTS:0A8U
34 GF Score
Price $1.23
GF Value $0.03
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Synlogic Cyclically Adjusted PS Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


Synlogic  (LTS:0A8U) Cyclically Adjusted PS Ratio Explanation

Compared with the regular PS Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PS Ratio smoothed out the fluctuations of revenue during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PS Ratio should give similar results to regular PS Ratio.


Synlogic Cyclically Adjusted PS Ratio Related Terms


Synlogic Cyclically Adjusted PS Ratio Historical Data

* Premium members only.

The historical data trend for Synlogic's Cyclically Adjusted PS Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Synlogic Cyclically Adjusted PS Ratio Chart

Synlogic Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PS Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 1.69 0.00

Synlogic Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted PS Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

LTS:0A8U vs APRE, MTVA, CNSP: Cyclically Adjusted PS Ratio Comparison

For the Biotechnology subindustry, Synlogic's Cyclically Adjusted PS Ratio, along with its competitors' market caps and Cyclically Adjusted PS Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Synlogic Cyclically Adjusted PS Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Synlogic's Cyclically Adjusted PS Ratio distribution charts can be found below:

* The bar in red indicates where Synlogic's Cyclically Adjusted PS Ratio falls into.


LTS:0A8U
34GF Score
Synlogic Inc LTS:0A8U
Cyclically Adjusted PS Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Synlogic Cyclically Adjusted PS Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PS Ratio takes the Revenue per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/S calculation. Because it considers this 10-year average, it's often referred to as the CAPS Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio.

Synlogic's Cyclically Adjusted Revenue per Share for the quarter that ended in Jun. 2026 is calculated as:

For example, Synlogic's adjusted Revenue per Share data for the three months ended in Jun. 2026 was:

Adj_RevenuePerShare=Revenue per Share/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=0/333.9520*333.9520
=0.000

Current CPI (Jun. 2026) = 333.9520.

Synlogic Quarterly Data

Revenue per Share CPI Adj_RevenuePerShare
201609 0.000 241.428 0.000
201612 0.000 241.432 0.000
201703 0.000 243.801 0.000
201706 0.000 244.955 0.000
201709 0.232 246.819 0.314
201712 0.102 246.524 0.138
201803 0.264 249.554 0.353
201806 0.154 251.989 0.204
201809 1.071 252.439 1.417
201812 0.066 251.233 0.088
201903 0.200 254.202 0.263
201906 0.193 256.143 0.252
201909 0.134 256.759 0.174
201912 0.539 256.974 0.700
202003 0.044 258.115 0.057
202006 0.191 257.797 0.247
202009 0.000 260.280 0.000
202012 0.000 260.474 0.000
202103 0.000 264.877 0.000
202106 0.071 271.696 0.087
202109 0.248 274.310 0.302
202112 0.123 278.802 0.147
202203 0.051 287.504 0.059
202206 0.032 296.311 0.036
202209 0.141 296.808 0.159
202212 0.022 296.797 0.025
202303 0.038 301.836 0.042
202306 0.007 305.109 0.008
202309 0.084 307.789 0.091
202312 0.301 306.746 0.328
202403 0.001 312.332 0.001
202406 0.000 314.175 0.000
202409 0.000 315.301 0.000
202412 0.001 315.605 0.001
202503 0.000 319.799 0.000
202506 0.000 322.561 0.000
202509 0.000 324.800 0.000
202512 0.000 324.054 0.000
202603 0.000 330.213 0.000
202606 0.000 333.952 0.000

Add all the adjusted revenue per share together and divide 10 will get our Cyclically Adjusted Revenue per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is Synlogic (LTS:0A8U) Overvalued in 2026?

Based on GuruFocus' analysis, Synlogic stock appears to be overvalued. The current stock price of $1.23 is trading 4000% above its estimated GF Value™ of $0.03. GuruFocus considers Synlogic to be Significantly Overvalued.

Key valuation signals for LTS:0A8U:

  • Cyclically Adjusted PS Ratio:
  • GF Value™: $0.03 vs. price of $1.23 (4000% above fair value)
  • GF Score™: 34/100 with 1 warning sign

No single metric tells the full story. See the LTS:0A8U stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Synlogic Business Description

Other Exchanges SYBX:USA
Address PO Box 30, Winchester, MA, USA, 01890
Synlogic Inc is a biopharmaceutical company focuses on rare metabolic disorders, with a program in phenylketonuria (PKU) and homocystinuria (HCU). The company's pipeline includes therapeutics for enteric hyperoxaluria, gout, and cystinuria. Using a proprietary approach, the company engineer GI-restricted, oral medicines from well-characterized probiotics. The pipeline drug candidates includes: labafenogene marselecobac (SYNB1934); SYNB1353 Classical Homocystinuria (HCU); SYNB8802 Enteric Hyperoxaluria; and SYNB2081 Gout. Engineered to be non-colonizing and reversible, the company offer oral administration, simplifying shipping and storage. The company operates in one operating segment: Discovery and development of Synthetic Biotics.
34GF Score

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Cyclically Adjusted PS Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.23
Price
$0.03
GF Value