Ionis Pharmaceuticals (FRA:ISI) Payments of Debt: €-604.1 Mil (TTM As of Jun. 2026)

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FRA:ISI Ionis Pharmaceuticals Inc FRA:ISI
73 GF Score
Price €48.07
GF Value €47.39
Valuation Fairly Valued
! 6 Warning Signs
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What is Ionis Pharmaceuticals Payments of Debt?

Ionis Pharmaceuticals FRA:ISI -1.42% 73 Payments of Debt is €-604.1 Mil as of Jun. 2026. GuruFocus rates FRA:ISI with a GF Score™ of 73/100 and a GF Value™ of €47.39 (Fairly Valued). The stock has 6 warning signs investors should review.

Ionis Pharmaceuticals's Payments of Debt for the three months ended in Jun. 2026 was €-375.5 Mil.

Ionis Pharmaceuticals's Payments of Debt for the trailing twelve months (TTM) ended in Jun. 2026 was €-604.1 Mil.

Ionis Pharmaceuticals Payments of Debt Related Terms

Ionis Pharmaceuticals Payments of Debt Historical Data

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The historical data trend for Ionis Pharmaceuticals's Payments of Debt can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ionis Pharmaceuticals Payments of Debt Chart

Ionis Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Payments of Debt
Get a 7-Day Free Trial Premium Member Only Premium Member Only -282.25 -47.85 -447.59 -42.66 -228.71

Ionis Pharmaceuticals Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Payments of Debt Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.04 -0.04 -228.61 -0.04 -375.46
FRA:ISI
73GF Score
Ionis Pharmaceuticals Inc FRA:ISI
Payments of Debt is just one metric. See GF Score™, valuation, warning signs, and more.
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Ionis Pharmaceuticals Payments of Debt Calculation

Payments of Debt represents all the cash outflow from debt, including both long-term debt and short-term debt.

Payments of Debt for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-604.1 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Payments of Debt →
What does a Payments of Debt of €-604.1 Mil mean?
Ionis Pharmaceuticals (FRA:ISI) has a Payments of Debt of €-604.1 Mil as of Jun. 2026. Payments of Debt is all the cash outflow from debt, including both long-term debt and short-term debt. View historical data on Ionis Pharmaceuticals and its competitors.
Is Ionis Pharmaceuticals' Payments of Debt too high?
Ionis Pharmaceuticals' current Payments of Debt is €-604.1 Mil. Overall, Ionis Pharmaceuticals has a GF Score™ of 73/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Ionis Pharmaceuticals' Payments of Debt compare to KYMR and PRAX?
Ionis Pharmaceuticals' Payments of Debt of €-604.1 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Payments of Debt for a Biotechnology company?
A good Payments of Debt depends on the Biotechnology industry context. However, Payments of Debt should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Payments of Debt mean?
A high Payments of Debt can signal that a stock is expensive relative to its fundamentals. Payments of Debt is all the cash outflow from debt, including both long-term debt and short-term debt. View historical data on Ionis Pharmaceuticals and its competitors. Ionis Pharmaceuticals's current Payments of Debt is €-604.1 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ionis Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Ionis Pharmaceuticals (FRA:ISI) is currently considered Fairly Valued. The stock's GF Value™ is €47.39, compared to a current price of €48.07 — trading 1.4% above its estimated fair value. The current Payments of Debt is €-604.1 Mil. Ionis Pharmaceuticals' overall GF Score™ is 73/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Payments of Debt calculated?
Payments of Debt is calculated from a company's financial statements. For Ionis Pharmaceuticals (FRA:ISI), the current Payments of Debt is €-604.1 Mil as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Ionis Pharmaceuticals (FRA:ISI) Overvalued in 2026?

Based on GuruFocus' analysis, Ionis Pharmaceuticals stock appears to be overvalued. The current stock price of €48.07 is trading 1.4% above its estimated GF Value™ of €47.39. GuruFocus considers Ionis Pharmaceuticals to be Fairly Valued.

Key valuation signals for FRA:ISI:

  • Payments of Debt: €-604.1 Mil
  • GF Value™: €47.39 vs. price of €48.07 (1.4% above fair value)
  • GF Score™: 73/100 with 6 warning signs

No single metric tells the full story. See the FRA:ISI stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.

Ionis Pharmaceuticals Business Description

Other Exchanges IONS:USA1IONS:Italy0JDI:UK
Address 2855 Gazelle Court, Carlsbad, CA, USA, 92010
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).
73GF Score

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Payments of Debt is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€48.07
Price
€47.39
GF Value