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Cizzle Biotechnology HoldingsLSE:CIZ Debt-to-EBITDA is 0.00 as of Dec. 2025. The stock has 4 warning signs investors should review. Among 311 Biotechnology companies, Cizzle Biotechnology Holdings ranks worse than 321543.09% on this metric.
Debt-to-EBITDA measures a company's ability to pay off its debt.
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for Cizzle Biotechnology Holdings's Debt-to-EBITDA or its related term are showing as below:
LSE:CIZ'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: -1.12 Med: -1.12 Max: -0.21
Current: -0.21
During the past 13 years, the highest Debt-to-EBITDA Ratio of Cizzle Biotechnology Holdings was -0.21. The lowest was -1.12. And the median was -1.12.
LSE:CIZ's Debt-to-EBITDA is ranked worse than 100% of 311
companies
in the Biotechnology industry
Industry Median: 1.39
vs LSE:CIZ: -0.21
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
Cizzle Biotechnology Holdings Debt-to-EBITDA Related Terms
Cizzle Biotechnology Holdings Debt-to-EBITDA Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
LSE:CIZ vs VRTX, REGN, RVMD: Debt-to-EBITDA Comparison
For the Biotechnology subindustry, Cizzle Biotechnology Holdings's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Cizzle Biotechnology Holdings Debt-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Cizzle Biotechnology Holdings's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Cizzle Biotechnology Holdings's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is two times the quarterly (Dec. 2025) EBITDA data.
Cizzle Biotechnology Holdings (LSE:CIZ) has a Debt-to-EBITDA of 0.00 as of Dec. 2025. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Cizzle Biotechnology Holdings. According to the industry distribution chart, Cizzle Biotechnology Holdings ranks #999999 out of 311 companies in the Biotechnology industry.
Is Cizzle Biotechnology Holdings' Debt-to-EBITDA too high?
Cizzle Biotechnology Holdings' current Debt-to-EBITDA is 0.00. Based on the distribution chart, Cizzle Biotechnology Holdings ranks #999999 out of 311 companies in the Biotechnology industry, which is in the bottom quartile relative to peers.
How does Cizzle Biotechnology Holdings' Debt-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Cizzle Biotechnology Holdings ranks #999999 out of 311 companies for Debt-to-EBITDA. This places Cizzle Biotechnology Holdings in the lower half of its industry. The industry median Debt-to-EBITDA is 1.39. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Biotechnology company?
The median Debt-to-EBITDA among Biotechnology companies is 1.39, based on 311 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Cizzle Biotechnology Holdings. For the Biotechnology industry, the median Debt-to-EBITDA is 1.39 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Cizzle Biotechnology Holdings's current Debt-to-EBITDA is 0.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Cizzle Biotechnology Holdings stock overvalued right now?
Cizzle Biotechnology Holdings (LSE:CIZ) has a current Debt-to-EBITDA of 0.00. The current Debt-to-EBITDA is 0.00. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For Cizzle Biotechnology Holdings (LSE:CIZ), the current Debt-to-EBITDA is 0.00 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Cizzle Biotechnology Holdings PLC is a holding company of a group of companies (the Group) whose principal activity is the early detection of lung cancer via the development of an immunoassay test for the CIZ1B biomarker. Designed as a simple blood test, it enables early diagnosis before symptoms appear-when treatment options can transform outcomes for patients and families.
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