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AstraZenecaSTU:ZEGA +1.30%87 Debt-to-EBITDA is 1.56 as of Jun. 2026, which is 40% below its 10-year median of 2.60. GuruFocus rates STU:ZEGA with a GF Score™ of 87/100 and a GF Value™ of €90.16. The stock has 1 warning sign investors should review. Among 681 Drug Manufacturers companies, AstraZeneca ranks better than 50.51% on this metric.
Debt-to-EBITDA measures a company's ability to pay off its debt.
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for AstraZeneca's Debt-to-EBITDA or its related term are showing as below:
STU:ZEGA'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: 1.49 Med: 2.6 Max: 6
Current: 1.58
During the past 13 years, the highest Debt-to-EBITDA Ratio of AstraZeneca was 6.00. The lowest was 1.49. And the median was 2.60.
STU:ZEGA's Debt-to-EBITDA is ranked better than 50.51% of 681
companies
in the Drug Manufacturers industry
Industry Median: 1.63
vs STU:ZEGA: 1.58
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
AstraZeneca Debt-to-EBITDA Related Terms
AstraZeneca Debt-to-EBITDA Historical Data
* Premium members only.
The historical data trend for AstraZeneca's Debt-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STU:ZEGA vs LLY, JNJ, ABBV: Debt-to-EBITDA Comparison
For the Drug Manufacturers - General subindustry, AstraZeneca's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
AstraZeneca Debt-to-EBITDA vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, AstraZeneca's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where AstraZeneca's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is four times the quarterly (Jun. 2026) EBITDA data.
AstraZeneca (STU:ZEGA) has a Debt-to-EBITDA of 1.56 as of Jun. 2026. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on AstraZeneca. This is 40% below median its historical median of 2.60. Over the past decade, AstraZeneca's Debt-to-EBITDA has ranged from 1.49 to 6.00. According to the industry distribution chart, AstraZeneca ranks #337 out of 681 companies in the Drug Manufacturers industry, placing it in the top 49.5%.
Is AstraZeneca's Debt-to-EBITDA too high?
AstraZeneca's current Debt-to-EBITDA of 1.56 is 40% below median its 10-year median of 2.60. Over the past 10 years, this metric has ranged from a low of 1.49 to a high of 6.00. The Drug Manufacturers industry median Debt-to-EBITDA is 1.63. AstraZeneca's value of 1.56 is 4.3% below this industry median. Based on the distribution chart, AstraZeneca ranks #337 out of 681 companies in the Drug Manufacturers industry, which is above the industry midpoint. Overall, AstraZeneca has a GF Score™ of 87/100, reflecting its overall financial health beyond just this single metric.
How does AstraZeneca's Debt-to-EBITDA compare to LLY and JNJ?
According to the Drug Manufacturers industry distribution chart, AstraZeneca ranks #337 out of 681 companies for Debt-to-EBITDA. This puts AstraZeneca in the upper half of its industry. The industry median Debt-to-EBITDA is 1.63. AstraZeneca's value of 1.56 is 4.3% below this benchmark. Historically, AstraZeneca's own Debt-to-EBITDA has ranged from 1.49 to 6.00 over the past decade. While the company's 10-year median is 2.60 vs. the industry median of 1.63, AstraZeneca has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Drug Manufacturers company?
The median Debt-to-EBITDA among Drug Manufacturers companies is 1.63, based on 681 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. AstraZeneca's current Debt-to-EBITDA of 1.56 is 4.3% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on AstraZeneca. For the Drug Manufacturers industry, the median Debt-to-EBITDA is 1.63 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. AstraZeneca's current Debt-to-EBITDA is 1.56, which is 40% below median its own 10-year median of 2.60. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AstraZeneca stock overvalued right now?
AstraZeneca (STU:ZEGA) has a current Debt-to-EBITDA of 1.56. The stock's GF Value™ is €90.16, compared to a current price of €78.00 — trading 13.5% below its estimated fair value. The current Debt-to-EBITDA is 1.56, which is 40% below median its 10-year median of 2.60 and 4.3% below the Drug Manufacturers industry median of 1.63. AstraZeneca's overall GF Score™ is 87/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For AstraZeneca (STU:ZEGA), the current Debt-to-EBITDA is 1.56 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is AstraZeneca (STU:ZEGA) Overvalued in 2026?
Based on GuruFocus' analysis, AstraZeneca stock appears to be undervalued.
The current stock price of €78.00 is trading 13.5% below its estimated GF Value™ of €90.16.
Key valuation signals for STU:ZEGA:
Debt-to-EBITDA: 1.56 (40% below median its 10-year median of 2.60)
GF Value™: €90.16 vs. price of €78.00 (13.5% below fair value)
Industry Position: 4.3% below the Drug Manufacturers median (#337 of 681)
No single metric tells the full story. See the STU:ZEGA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
A merger between Astra of Sweden and Zeneca of the United Kingdom formed AstraZeneca in 1999. The firm sells branded drugs across a number of major therapeutic areas, including oncology (over 40% of total revenue), cardiovascular, renal, and metabolic (over 20%), rare disease (16%), and respiratory and immunology (15%). The majority of sales comes from international markets, with the United States representing close to one-third of its sales.
87GF Score
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