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PolyPidPYPD +6.95%33 Debt-to-Equity is 0.27 as of Mar. 2026, which is 77% below its 10-year median of 1.19. GuruFocus rates PYPD with a GF Score™ of 33/100. Among 966 Biotechnology companies, PolyPid ranks worse than 61.08% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for PolyPid's Debt-to-Equity or its related term are showing as below:
PYPD'
s Debt-to-Equity Range Over the Past 10 Years
Min: -5.62 Med: 1.19 Max: 102.65
Current: 0.27
During the past 12 years, the highest Debt-to-Equity Ratio of PolyPid was 102.65. The lowest was -5.62. And the median was 1.19.
PYPD's Debt-to-Equity is ranked worse than 61.08% of 966
companies
in the Biotechnology industry
Industry Median: 0.16
vs PYPD: 0.27
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
PolyPid Debt-to-Equity Related Terms
PolyPid Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for PolyPid's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PYPD vs NRXS, INO, ICCC: Debt-to-Equity Comparison
For the Biotechnology subindustry, PolyPid's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
PolyPid Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, PolyPid's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where PolyPid's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PolyPid (PYPD) has a Debt-to-Equity of 0.27 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on PolyPid and its competitors. This is 77% below median its historical median of 1.19. According to the industry distribution chart, PolyPid ranks #590 out of 966 companies in the Biotechnology industry, placing it in the top 61.1%.
Is PolyPid's Debt-to-Equity too high?
PolyPid's current Debt-to-Equity of 0.27 is 77% below median its 10-year median of 1.19. The Biotechnology industry median Debt-to-Equity is 0.16. PolyPid's value of 0.27 is 68.8% above this industry median. Based on the distribution chart, PolyPid ranks #590 out of 966 companies in the Biotechnology industry, which is below the industry midpoint. Overall, PolyPid has a GF Score™ of 33/100, reflecting its overall financial health beyond just this single metric.
How does PolyPid's Debt-to-Equity compare to NRXS and INO?
According to the Biotechnology industry distribution chart, PolyPid ranks #590 out of 966 companies for Debt-to-Equity. This places PolyPid in the lower half of its industry. The industry median Debt-to-Equity is 0.16. PolyPid's value of 0.27 is 68.8% above this benchmark. While the company's 10-year median is 1.19 vs. the industry median of 0.16, PolyPid has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 966 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. PolyPid's current Debt-to-Equity of 0.27 is 68.8% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on PolyPid and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. PolyPid's current Debt-to-Equity is 0.27, which is 77% below median its own 10-year median of 1.19. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is PolyPid stock overvalued right now?
PolyPid (PYPD) has a current Debt-to-Equity of 0.27. The current Debt-to-Equity is 0.27, which is 77% below median its 10-year median of 1.19 and 68.8% above the Biotechnology industry median of 0.16. PolyPid's overall GF Score™ is 33/100. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For PolyPid (PYPD), the current Debt-to-Equity is 0.27 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
PolyPid Ltd is a clinical-stage biopharmaceutical company engaged in the research and development of products based on PLEX (Polymer-Lipid Encapsulation MatriX), the company's proprietary drug delivery technology. PLEX is capable of encapsulating many types of drugs to enable targeted, localized drug delivery into the body over extended periods of time with pre-determined release rates thus optimizing drug treatment regimens. BonyPid, PolyPid, Opzifend, Ssisurg, Elyfssi, Baczenssi, Opzifend and Bacyssio are trademarks of the company. The company's product candidate include D-PLEX100 for prevention of SSI in soft tissue and OncoPLEX which can be a potential Intra-tumoral therapy.
33GF Score
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