OSE Immunotherapeutics (XPAR:OSE) EBITDA Margin %: -1,511.11% (As of Dec. 2025)


XPAR:OSE OSE Immunotherapeutics SA XPAR:OSE
53 GF Score
Price €3.05
GF Value €1.49
Valuation Significantly Overvalued
! 6 Warning Signs
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What is OSE Immunotherapeutics EBITDA Margin %?

OSE Immunotherapeutics XPAR:OSE -4.98% 53 EBITDA Margin % is -1,511.11% as of Dec. 2025. GuruFocus rates XPAR:OSE with a GF Score™ of 53/100 and a GF Value™ of €1.49 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 944 Biotechnology companies, OSE Immunotherapeutics ranks worse than 80.93% on this metric.

EBITDA Margin % is calculated as EBITDA divided by its Revenue. OSE Immunotherapeutics's EBITDA for the six months ended in Dec. 2025 was €-19.58 Mil. OSE Immunotherapeutics's Revenue for the six months ended in Dec. 2025 was €1.30 Mil. Therefore, OSE Immunotherapeutics's EBITDA margin for the quarter that ended in Dec. 2025 was -1,511.11%.


OSE Immunotherapeutics  (XPAR:OSE) EBITDA Margin % Explanation

EBITDA Margin % is the ratio of EBITDA divided by net sales or Revenue. It is an performance metric measuring company's operating profitability. EBITDA Margin takes depreciation and amortization, interest expense and tax into account, which makes it easy to compare the relative profitability of companies of different sizes in the same industry.


OSE Immunotherapeutics EBITDA Margin % Related Terms


OSE Immunotherapeutics EBITDA Margin % Historical Data

* Premium members only.

The historical data trend for OSE Immunotherapeutics's EBITDA Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OSE Immunotherapeutics EBITDA Margin % Chart

OSE Immunotherapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EBITDA Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -52.16 -71.65 -785.86 66.28 -1,196.83

OSE Immunotherapeutics Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
EBITDA Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -963.87 92.85 -2,141.52 -888.96 -1,511.11

XPAR:OSE vs VRTX, REGN, ALNY: EBITDA Margin % Comparison

For the Biotechnology subindustry, OSE Immunotherapeutics's EBITDA Margin %, along with its competitors' market caps and EBITDA Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OSE Immunotherapeutics EBITDA Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, OSE Immunotherapeutics's EBITDA Margin % distribution charts can be found below:

* The bar in red indicates where OSE Immunotherapeutics's EBITDA Margin % falls into.


XPAR:OSE
53GF Score
OSE Immunotherapeutics SA XPAR:OSE
EBITDA Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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OSE Immunotherapeutics EBITDA Margin % Calculation

EBITDA margin is the ratio of EBITDA divided by net sales or Revenue, usually presented in percent.

OSE Immunotherapeutics's EBITDA Margin % for the fiscal year that ended in Dec. 2025 is calculated as

EBITDA Margin %=EBITDA (A: Dec. 2025 )/Revenue (A: Dec. 2025 )
=-31.345/2.619
=-1,196.83 %

OSE Immunotherapeutics's EBITDA Margin % for the quarter that ended in Dec. 2025 is calculated as

EBITDA Margin %=EBITDA (Q: Dec. 2025 )/Revenue (Q: Dec. 2025 )
=-19.584/1.296
=-1,511.11 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EBITDA Margin % →
What does a EBITDA Margin % of -1,511.11% mean?
OSE Immunotherapeutics (XPAR:OSE) has a EBITDA Margin % of -1,511.11% as of Dec. 2025. EBITDA Margin is the ratio of EBITDA divided by net sales or Revenue, usually presented in percent. View historical data on OSE Immunotherapeutics and its competitors. According to the industry distribution chart, OSE Immunotherapeutics ranks #764 out of 944 companies in the Biotechnology industry, placing it in the top 80.9%.
Is OSE Immunotherapeutics' EBITDA Margin % too high?
OSE Immunotherapeutics' current EBITDA Margin % is -1,511.11%. Based on the distribution chart, OSE Immunotherapeutics ranks #764 out of 944 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, OSE Immunotherapeutics has a GF Score™ of 53/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OSE Immunotherapeutics' EBITDA Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, OSE Immunotherapeutics ranks #764 out of 944 companies for EBITDA Margin %. This places OSE Immunotherapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EBITDA Margin % for a Biotechnology company?
A good EBITDA Margin % depends on the Biotechnology industry context. However, EBITDA Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EBITDA Margin % mean?
A high EBITDA Margin % can signal that a stock is expensive relative to its fundamentals. EBITDA Margin is the ratio of EBITDA divided by net sales or Revenue, usually presented in percent. View historical data on OSE Immunotherapeutics and its competitors. OSE Immunotherapeutics's current EBITDA Margin % is -1,511.11%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OSE Immunotherapeutics stock overvalued right now?
Based on GuruFocus' analysis, OSE Immunotherapeutics (XPAR:OSE) is currently considered Significantly Overvalued. The stock's GF Value™ is €1.49, compared to a current price of €3.05 — trading 104.7% above its estimated fair value. The current EBITDA Margin % is -1,511.11%. OSE Immunotherapeutics' overall GF Score™ is 53/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EBITDA Margin % calculated?
EBITDA Margin % is calculated from a company's financial statements. For OSE Immunotherapeutics (XPAR:OSE), the current EBITDA Margin % is -1,511.11% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OSE Immunotherapeutics (XPAR:OSE) Overvalued in 2026?

Based on GuruFocus' analysis, OSE Immunotherapeutics stock appears to be overvalued. The current stock price of €3.05 is trading 104.7% above its estimated GF Value™ of €1.49. GuruFocus considers OSE Immunotherapeutics to be Significantly Overvalued.

Key valuation signals for XPAR:OSE:

  • EBITDA Margin %: -1,511.11%
  • GF Value™: €1.49 vs. price of €3.05 (104.7% above fair value)
  • GF Score™: 53/100 with 6 warning signs

No single metric tells the full story. See the XPAR:OSE stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OSE Immunotherapeutics Business Description

Other Exchanges ORPOF:USA0RAD:UK6OP:Germany
Address 22, Boulevard Benoni Goullin, Nantes, FRA, 44200
OSE Immunotherapeutics SA is a France-based biotechnology company focused on the development of immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases. The product portfolio of the company comprises Tedopi, OSE-172, OSE-703, FR104 and OSE-127.
53GF Score

Get the complete analysis for XPAR:OSE

EBITDA Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€3.05
Price
€1.49
GF Value