Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Coiled TherapeuticsCOTXF 21 EV-to-EBITDA is -12.41 as of Aug. 09, 2026. GuruFocus rates COTXF with a GF Score™ of 21/100. The stock has 4 warning signs investors should review. Among 409 Biotechnology companies, Coiled Therapeutics ranks worse than 244498.53% on this metric.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Coiled Therapeutics's enterprise value is $55.94 Mil.
Coiled Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-4.51 Mil. Therefore, Coiled Therapeutics's EV-to-EBITDA for today is -12.41.
The historical rank and industry rank for Coiled Therapeutics's EV-to-EBITDA or its related term are showing as below:
COTXF'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -12.04 Med: -0.99 Max: 0.21
Current: -12.04
During the past 5 years, the highest EV-to-EBITDA of Coiled Therapeutics was 0.21. The lowest was -12.04. And the median was -0.99.
COTXF's EV-to-EBITDA is ranked worse than 100% of 409
companies
in the Biotechnology industry
Industry Median: 12.99
vs COTXF: -12.04
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Coiled Therapeutics's PE Ratio (TTM) for today is calculated as:
Coiled Therapeutics's share price for today is $0.135.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. Coiled Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Dec. 2025 was $-0.294.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
The historical data trend for Coiled Therapeutics's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
COTXF vs VRTX, REGN, RVMD: EV-to-EBITDA Comparison
For the Biotechnology subindustry, Coiled Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Coiled Therapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Coiled Therapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Coiled Therapeutics's EV-to-EBITDA falls into.
Coiled Therapeutics's current Enterprise Value is $55.94 Mil.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. Coiled Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-4.51 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Coiled Therapeutics (COTXF) has a EV-to-EBITDA of -12.41 as of Aug. 09, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Coiled Therapeutics. According to the industry distribution chart, Coiled Therapeutics ranks #999999 out of 409 companies in the Biotechnology industry.
Is Coiled Therapeutics' EV-to-EBITDA too high?
Coiled Therapeutics' current EV-to-EBITDA is -12.41. Based on the distribution chart, Coiled Therapeutics ranks #999999 out of 409 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Coiled Therapeutics has a GF Score™ of 21/100, reflecting its overall financial health beyond just this single metric.
How does Coiled Therapeutics' EV-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Coiled Therapeutics ranks #999999 out of 409 companies for EV-to-EBITDA. This places Coiled Therapeutics in the lower half of its industry. The industry median EV-to-EBITDA is 12.99. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 12.99, based on 409 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Coiled Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 12.99 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Coiled Therapeutics's current EV-to-EBITDA is -12.41. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Coiled Therapeutics stock overvalued right now?
Coiled Therapeutics (COTXF) has a current EV-to-EBITDA of -12.41. The current EV-to-EBITDA is -12.41. Coiled Therapeutics' overall GF Score™ is 21/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Coiled Therapeutics (COTXF), the current EV-to-EBITDA is -12.41 as of Aug. 09, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Coiled Therapeutics PLC principal activity of the Company is to develop pre-clinical next generation medicines focused on hard-to-treat cancers. The Group operated in the single business segment of biotechnology.
21GF Score
Get the complete analysis for COTXF
EV-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
COTXF has been successfully added to your 
