HighTide TherapeuticsHTTIF 14 EV-to-EBITDA is -3.89 as of Jul. 08, 2026. GuruFocus rates HTTIF with a GF Score™ of 14/100. The stock has 3 warning signs investors should review. Among 390 Biotechnology companies, HighTide Therapeutics ranks worse than 256410% on this metric.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, HighTide Therapeutics's enterprise value is $122.16 Mil.
HighTide Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-31.40 Mil. Therefore, HighTide Therapeutics's EV-to-EBITDA for today is -3.89.
The historical rank and industry rank for HighTide Therapeutics's EV-to-EBITDA or its related term are showing as below:
HTTIF'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -3.9 Med: 0 Max: 0
Current: -3.9
HTTIF's EV-to-EBITDA is ranked worse than 100% of 390
companies
in the Biotechnology industry
Industry Median: 13.095
vs HTTIF: -3.90
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
HighTide Therapeutics's PE Ratio (TTM) for today is calculated as:
HighTide Therapeutics's share price for today is $0.3893.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. HighTide Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Dec. 2025 was $-0.072.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
HighTide Therapeutics EV-to-EBITDA Historical Data
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The historical data trend for HighTide Therapeutics's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
HTTIF vs VRTX, REGN, ALNY: EV-to-EBITDA Comparison
For the Biotechnology subindustry, HighTide Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
HighTide Therapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, HighTide Therapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where HighTide Therapeutics's EV-to-EBITDA falls into.
HighTide Therapeutics's current Enterprise Value is $122.16 Mil.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. HighTide Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-31.40 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
HighTide Therapeutics (HTTIF) has a EV-to-EBITDA of -3.89 as of Jul. 08, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on HighTide Therapeutics. According to the industry distribution chart, HighTide Therapeutics ranks #999999 out of 390 companies in the Biotechnology industry.
Is HighTide Therapeutics' EV-to-EBITDA too high?
HighTide Therapeutics' current EV-to-EBITDA is -3.89. Based on the distribution chart, HighTide Therapeutics ranks #999999 out of 390 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, HighTide Therapeutics has a GF Score™ of 14/100, reflecting its overall financial health beyond just this single metric.
How does HighTide Therapeutics' EV-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, HighTide Therapeutics ranks #999999 out of 390 companies for EV-to-EBITDA. This places HighTide Therapeutics in the lower half of its industry. The industry median EV-to-EBITDA is 13.10. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 13.10, based on 390 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on HighTide Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 13.10 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. HighTide Therapeutics's current EV-to-EBITDA is -3.89. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is HighTide Therapeutics stock overvalued right now?
HighTide Therapeutics (HTTIF) has a current EV-to-EBITDA of -3.89. The current EV-to-EBITDA is -3.89. HighTide Therapeutics' overall GF Score™ is 14/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For HighTide Therapeutics (HTTIF), the current EV-to-EBITDA is -3.89 as of Jul. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
HighTide Therapeutics Inc is a biopharmaceutical company focused on the discovery and development of first-in-class multifunctional, multi-targeted therapies for cardiovascular-kidney-metabolic (CKM) diseases and related metabolic disorders. The company is developing a pipeline of proprietary drug candidates targeting indications including type 2 diabetes mellitus, chronic kidney disease, obesity, metabolic dysfunction-associated steatohepatitis (MASH), and primary sclerosing cholangitis (PSC). Its core product candidate, HTD1801 (berberine ursodeoxycholate), is an orally delivered first-in-class anti-inflammatory metabolic modulator designed to target dual pathways involving AMPK activation and NLRP3 inflammasome inhibition.
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