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Opus GeneticsFRA:R3X1 24 EV-to-FCF is -5.51 as of Jul. 18, 2026. GuruFocus rates FRA:R3X1 with a GF Score™ of 24/100 and a GF Value™ of €0.31 (Significantly Overvalued). The stock has 4 warning signs investors should review. Among 335 Biotechnology companies, Opus Genetics ranks worse than 298507.16% on this metric.
EV-to-FCF is calculated as enterprise value divided by its free cash flow. As of today, Opus Genetics's Enterprise Value is €184.76 Mil.
Opus Genetics's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 was €-33.56 Mil. Therefore, Opus Genetics's EV-to-FCF for today is -5.51.
The historical rank and industry rank for Opus Genetics's EV-to-FCF or its related term are showing as below:
FRA:R3X1'
s EV-to-FCF Range Over the Past 10 Years
Min: -17.06 Med: -1.09 Max: 6.12
Current: -5.4
During the past 7 years, the highest EV-to-FCF of Opus Genetics was 6.12. The lowest was -17.06. And the median was -1.09.
FRA:R3X1's EV-to-FCF is ranked worse than 100% of 335
companies
in the Biotechnology industry
Industry Median: 15.51
vs FRA:R3X1: -5.40
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Opus Genetics's PE Ratio (TTM) for today is calculated as:
Opus Genetics's share price for today is €2.80.
Opus Genetics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-1.145.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Free Cash Flow is an important financial metric because it represents the actual amount of cash at a company's disposal. Companies with a low EV-to-FCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Opus Genetics EV-to-FCF Related Terms
Opus Genetics EV-to-FCF Historical Data
* Premium members only.
The historical data trend for Opus Genetics's EV-to-FCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
FRA:R3X1 vs PALI, VSTM, GALT: EV-to-FCF Comparison
For the Biotechnology subindustry, Opus Genetics's EV-to-FCF, along with its competitors' market caps and EV-to-FCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Opus Genetics EV-to-FCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Opus Genetics's EV-to-FCF distribution charts can be found below:
* The bar in red indicates where Opus Genetics's EV-to-FCF falls into.
Opus Genetics's current Enterprise Value is €184.76 Mil.
Opus Genetics's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-33.56 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Opus Genetics (FRA:R3X1) has a EV-to-FCF of -5.51 as of Jul. 18, 2026. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Opus Genetics and its competitors. According to the industry distribution chart, Opus Genetics ranks #999999 out of 335 companies in the Biotechnology industry.
Is Opus Genetics' EV-to-FCF too high?
Opus Genetics' current EV-to-FCF is -5.51. Based on the distribution chart, Opus Genetics ranks #999999 out of 335 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Opus Genetics has a GF Score™ of 24/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Opus Genetics' EV-to-FCF compare to PALI and VSTM?
According to the Biotechnology industry distribution chart, Opus Genetics ranks #999999 out of 335 companies for EV-to-FCF. This places Opus Genetics in the lower half of its industry. The industry median EV-to-FCF is 15.51. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-FCF for a Biotechnology company?
The median EV-to-FCF among Biotechnology companies is 15.51, based on 335 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-FCF significantly above this median, while those in the bottom quartile fall well below. However, EV-to-FCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-FCF mean?
A high EV-to-FCF can signal that a stock is expensive relative to its fundamentals. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Opus Genetics and its competitors. For the Biotechnology industry, the median EV-to-FCF is 15.51 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Opus Genetics's current EV-to-FCF is -5.51. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Opus Genetics stock overvalued right now?
Based on GuruFocus' analysis, Opus Genetics (FRA:R3X1) is currently considered Significantly Overvalued. The stock's GF Value™ is €0.31, compared to a current price of €2.80 — trading 803.2% above its estimated fair value. The current EV-to-FCF is -5.51. Opus Genetics' overall GF Score™ is 24/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-FCF calculated?
EV-to-FCF is calculated from a company's financial statements. For Opus Genetics (FRA:R3X1), the current EV-to-FCF is -5.51 as of Jul. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Opus Genetics (FRA:R3X1) Overvalued in 2026?
Based on GuruFocus' analysis, Opus Genetics stock appears to be overvalued.
The current stock price of €2.80 is trading 803.2% above its estimated GF Value™ of €0.31.
GuruFocus considers Opus Genetics to be Significantly Overvalued.
Key valuation signals for FRA:R3X1:
EV-to-FCF: -5.51
GF Value™: €0.31 vs. price of €2.80 (803.2% above fair value)
No single metric tells the full story. See the FRA:R3X1 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Opus Genetics Inc is a clinical-stage ophthalmic biopharmaceutical company developing therapies to treat patients with inherited retinal diseases (IRDs) and therapies to treat patients with other retinal and refractive disorders. The pipeline includes seven adeno-associated virus (AAV)-based programs, led by OPGx-LCA5 for LCA5-related mutations and OPGx-BEST1 for BEST1-related retinal degeneration, with additional candidates targeting RHO, CNGB1, RDH12, NMNAT1, and MERTK. The company operates in one operating segment, which is the business of developing products related to vision performance and health.
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