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EV-to-FCF is calculated as enterprise value divided by its free cash flow. As of today, Karyopharm Therapeutics's Enterprise Value is €263.7 Mil.
Karyopharm Therapeutics's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 was €-51.0 Mil. Therefore, Karyopharm Therapeutics's EV-to-FCF for today is -5.17.
The historical rank and industry rank for Karyopharm Therapeutics's EV-to-FCF or its related term are showing as below:
STU:25K0'
s EV-to-FCF Range Over the Past 10 Years
Min: -10.1 Med: -3.33 Max: -0.18
Current: -5.09
During the past 13 years, the highest EV-to-FCF of Karyopharm Therapeutics was -0.18. The lowest was -10.10. And the median was -3.33.
STU:25K0's EV-to-FCF is ranked worse than 100% of 340
companies
in the Biotechnology industry
Industry Median: 14.79
vs STU:25K0: -5.09
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Karyopharm Therapeutics's PE Ratio (TTM) for today is calculated as:
Karyopharm Therapeutics's share price for today is €6.15.
Karyopharm Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-12.949.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Free Cash Flow is an important financial metric because it represents the actual amount of cash at a company's disposal. Companies with a low EV-to-FCF ratio, combined with a strong balance sheet are generally considered as undervalued.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STU:25K0 vs CHRS, TARA, CNTN: EV-to-FCF Comparison
For the Biotechnology subindustry, Karyopharm Therapeutics's EV-to-FCF, along with its competitors' market caps and EV-to-FCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Karyopharm Therapeutics EV-to-FCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Karyopharm Therapeutics's EV-to-FCF distribution charts can be found below:
* The bar in red indicates where Karyopharm Therapeutics's EV-to-FCF falls into.
Karyopharm Therapeutics's current Enterprise Value is €263.7 Mil.
Karyopharm Therapeutics's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was €-51.0 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Karyopharm Therapeutics (STU:25K0) has a EV-to-FCF of -5.17 as of Jul. 24, 2026. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Karyopharm Therapeutics and its competitors. According to the industry distribution chart, Karyopharm Therapeutics ranks #999999 out of 340 companies in the Biotechnology industry.
Is Karyopharm Therapeutics' EV-to-FCF too high?
Karyopharm Therapeutics' current EV-to-FCF is -5.17. Based on the distribution chart, Karyopharm Therapeutics ranks #999999 out of 340 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Karyopharm Therapeutics has a GF Score™ of 60/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Karyopharm Therapeutics' EV-to-FCF compare to CHRS and TARA?
According to the Biotechnology industry distribution chart, Karyopharm Therapeutics ranks #999999 out of 340 companies for EV-to-FCF. This places Karyopharm Therapeutics in the lower half of its industry. The industry median EV-to-FCF is 14.79. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-FCF for a Biotechnology company?
The median EV-to-FCF among Biotechnology companies is 14.79, based on 340 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-FCF significantly above this median, while those in the bottom quartile fall well below. However, EV-to-FCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-FCF mean?
A high EV-to-FCF can signal that a stock is expensive relative to its fundamentals. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Karyopharm Therapeutics and its competitors. For the Biotechnology industry, the median EV-to-FCF is 14.79 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Karyopharm Therapeutics's current EV-to-FCF is -5.17. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Karyopharm Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Karyopharm Therapeutics (STU:25K0) is currently considered Modestly Overvalued. The stock's GF Value™ is €5.22, compared to a current price of €6.15 — trading 17.8% above its estimated fair value. The current EV-to-FCF is -5.17. Karyopharm Therapeutics' overall GF Score™ is 60/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-FCF calculated?
EV-to-FCF is calculated from a company's financial statements. For Karyopharm Therapeutics (STU:25K0), the current EV-to-FCF is -5.17 as of Jul. 24, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Karyopharm Therapeutics (STU:25K0) Overvalued in 2026?
Based on GuruFocus' analysis, Karyopharm Therapeutics stock appears to be overvalued.
The current stock price of €6.15 is trading 17.8% above its estimated GF Value™ of €5.22.
GuruFocus considers Karyopharm Therapeutics to be Modestly Overvalued.
Key valuation signals for STU:25K0:
EV-to-FCF: -5.17
GF Value™: €5.22 vs. price of €6.15 (17.8% above fair value)
No single metric tells the full story. See the STU:25K0 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
60GF Score
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