Annexin Pharmaceuticals ABOSTO:ANNX +0.40%23 Piotroski F-Score is 3 as of Jun. 27, 2026, which is at its 10-year median of 3.00. GuruFocus rates OSTO:ANNX with a GF Score™ of 23/100. The stock has 1 warning sign investors should review. Among 1,342 Biotechnology companies, Annexin Pharmaceuticals AB ranks better than 54.99% on this metric.
Warning Sign:
Piotroski F-Score of 3 is low, which usually implies poor business operation.
The zones of discrimination were as such:
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Annexin Pharmaceuticals AB has an F-score of 3. It is a bad or low score, which usually implies poor business operation.
The historical rank and industry rank for Annexin Pharmaceuticals AB's Piotroski F-Score or its related term are showing as below:
OSTO:ANNX'
s Piotroski F-Score Range Over the Past 10 Years
Min: 2 Med: 3 Max: 4
Current: 3
During the past 11 years, the highest Piotroski F-Score of Annexin Pharmaceuticals AB was 4. The lowest was 2. And the median was 3.
Annexin Pharmaceuticals AB (OSTO:ANNX) Piotroski F-Score Explanation
The developer of the system is Joseph D. Piotroski is relatively unknown accounting professor who shuns publicity and rarely gives interviews.
He graduated from the University of Illinois with a B.S. in accounting in 1989, received an M.B.A. from Indiana University in 1994. Five years later, in 1999, after earning a Ph.D. in accounting from the University of Michigan, he became an associate professor of accounting at the University of Chicago.
He wanted to see if he can develop a system (using a simple nine-point scoring system) that can increase the returns of a strategy of investing in low price to book (referred to in the paper as high book to market) value companies.
What he found was something that exceeded his most optimistic expectations.
Buying only those companies that scored highest (8 or 9) on his nine-point scale, or F-Score as he called it, over the 20 year period from 1976 to 1996 led to an average out-performance over the market of 13.4%.
Even more impressive were the results of a strategy of investing in the highest F-Score companies (8 or 9) and shorting companies with the lowest F-Score (0 or 1).
Over the same period from 1976 to 1996 (20 years) this strategy led to an average yearly return of 23%, substantially outperforming the average S&P 500 index return of 15.83% over the same period.
Annexin Pharmaceuticals AB Piotroski F-Score Related Terms
Annexin Pharmaceuticals AB Piotroski F-Score Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Annexin Pharmaceuticals AB Piotroski F-Score Chart
OSTO:ANNX vs VRTX, REGN, ALNY: Piotroski F-Score Comparison
For the Biotechnology subindustry, Annexin Pharmaceuticals AB's Piotroski F-Score, along with its competitors' market caps and Piotroski F-Score data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Annexin Pharmaceuticals AB Piotroski F-Score vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Annexin Pharmaceuticals AB's Piotroski F-Score distribution charts can be found below:
* The bar in red indicates where Annexin Pharmaceuticals AB's Piotroski F-Score falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
*Note: If the latest quarterly/semi-annual/annual total assets data is 0, then we will use previous quarterly/semi-annual/annual data for all the items in the balance sheet.
Profitability
Question 1. Return on Assets (ROA)
Net income before extraordinary items for the year divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Annexin Pharmaceuticals AB's current Net Income (TTM) was -39.44.
==> Negative ==> Score 0.
Question 2. Cash Flow Return on Assets (CFROA)
Net cash flow from operating activities (operating cash flow) divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Annexin Pharmaceuticals AB's current Cash Flow from Operations (TTM) was -39.00.
==> Negative ==> Score 0.
Question 3. Change in Return on Assets
Compare this year's return on assets (1) to last year's return on assets.
Annexin Pharmaceuticals AB's return on assets of this year was -0.82134005. Annexin Pharmaceuticals AB's return on assets of last year was -3.87486242.
==> This year is higher. ==> Score 1.
Question 4. Quality of Earnings (Accrual)
Compare Cash flow return on assets (2) to return on assets (1)
Annexin Pharmaceuticals AB's gearing of this year was 0. Annexin Pharmaceuticals AB's gearing of last year was 0.
==> This year is lower or equal to last year. ==> Score 1.
Question 6. Change in Working Capital (Liquidity)
Compare this year's current ratio (current assets divided by current liabilities) to last year's current ratio.
Score 1 if this year's current ratio is higher, 0 if it's lower
Annexin Pharmaceuticals AB's current ratio of this year was 3.31385943. Annexin Pharmaceuticals AB's current ratio of last year was 9.04247857.
==> Last year's current ratio is higher ==> Score 0.
Question 7. Change in Shares in Issue
Compare the number of shares in issue this year, to the number in issue last year.
Score 0 if there is larger number of shares in issue this year, 1 otherwise.
Annexin Pharmaceuticals AB's number of shares in issue this year was 7.166. Annexin Pharmaceuticals AB's number of shares in issue last year was 6.719.
==> There is larger number of shares in issue this year. ==> Score 0.
Efficiency
Question 8. Change in Gross Margin
Compare this year's gross margin (Gross Profit divided by sales) to last year's.
Score 1 if this year's gross margin is higher, 0 if it's lower.
Annexin Pharmaceuticals AB's gross margin of this year was . Annexin Pharmaceuticals AB's gross margin of last year was .
==> Last year's gross margin is higher ==> Score 0.
Question 9. Change in asset turnover
Compare this year's asset turnover (total sales for the year divided by total assets at the beginning of the year) to last year's asset turnover ratio.
Score 1 if this year's asset turnover ratio is higher, 0 if it's lower
Annexin Pharmaceuticals AB's asset turnover of this year was 0. Annexin Pharmaceuticals AB's asset turnover of last year was 0.
==> Last year's asset turnover is higher ==> Score 0.
Evaluation
Piotroski F-Score
=
Que. 1
+
Que. 2
+
Que. 3
+
Que. 4
+
Que. 5
+
Que. 6
+
Que. 7
+
Que. 8
+
Que. 9
=
0
+
0
+
1
+
1
+
1
+
0
+
0
+
0
+
0
=
3
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Annexin Pharmaceuticals AB has an F-score of 3. It is a bad or low score, which usually implies poor business operation.
Annexin Pharmaceuticals AB (OSTO:ANNX) has a Piotroski F-Score of 3 as of Jun. 27, 2026. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Annexin Pharmaceuticals AB and its competitors. This is near median its historical median of 3.00. Over the past decade, Annexin Pharmaceuticals AB's Piotroski F-Score has ranged from 2.00 to 4.00. According to the industry distribution chart, Annexin Pharmaceuticals AB ranks #604 out of 1342 companies in the Biotechnology industry, placing it in the top 45%.
Is Annexin Pharmaceuticals AB's Piotroski F-Score too high?
Annexin Pharmaceuticals AB's current Piotroski F-Score of 3 is near median its 10-year median of 3.00. Over the past 10 years, this metric has ranged from a low of 2.00 to a high of 4.00. The Biotechnology industry median Piotroski F-Score is 3.00. Annexin Pharmaceuticals AB's value of 3 is 0% at this industry median. Based on the distribution chart, Annexin Pharmaceuticals AB ranks #604 out of 1342 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Annexin Pharmaceuticals AB has a GF Score™ of 23/100, reflecting its overall financial health beyond just this single metric.
How does Annexin Pharmaceuticals AB's Piotroski F-Score compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Annexin Pharmaceuticals AB ranks #604 out of 1342 companies for Piotroski F-Score. This puts Annexin Pharmaceuticals AB in the upper half of its industry. The industry median Piotroski F-Score is 3.00. Annexin Pharmaceuticals AB's value of 3 is 0% at this benchmark. Historically, Annexin Pharmaceuticals AB's own Piotroski F-Score has ranged from 2.00 to 4.00 over the past decade. While the company's 10-year median is 3.00 vs. the industry median of 3.00, Annexin Pharmaceuticals AB has consistently been at the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Piotroski F-Score for a Biotechnology company?
The median Piotroski F-Score among Biotechnology companies is 3.00, based on 1,342 companies in the industry. Companies in the top quartile (top 25%) have a Piotroski F-Score significantly above this median, while those in the bottom quartile fall well below. However, Piotroski F-Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Annexin Pharmaceuticals AB's current Piotroski F-Score of 3 is 0% at the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Piotroski F-Score mean?
A high Piotroski F-Score can signal that a stock is expensive relative to its fundamentals. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Annexin Pharmaceuticals AB and its competitors. For the Biotechnology industry, the median Piotroski F-Score is 3.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Annexin Pharmaceuticals AB's current Piotroski F-Score is 3, which is near median its own 10-year median of 3.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Annexin Pharmaceuticals AB stock overvalued right now?
Annexin Pharmaceuticals AB (OSTO:ANNX) has a current Piotroski F-Score of 3. The current Piotroski F-Score is 3, which is near median its 10-year median of 3.00 and 0% at the Biotechnology industry median of 3.00. Annexin Pharmaceuticals AB's overall GF Score™ is 23/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Piotroski F-Score calculated?
Piotroski F-Score is calculated from a company's financial statements. For Annexin Pharmaceuticals AB (OSTO:ANNX), the current Piotroski F-Score is 3 as of Jun. 27, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Annexin Pharmaceuticals AB is a biotechnology company. It is developing biological drug candidate ANXV, a recombinant human protein Annexin A5 for treatment of various cardiovascular diseases. The company also focuses on development of ANXV for the treatment of retinal vein occlusion.
23GF Score
Get the complete analysis for OSTO:ANNX
Piotroski F-Score is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
OSTO:ANNX has been successfully added to your 
