ANTX (AN2 Therapeutics) Operating Margin %: 0.00% (As of Mar. 2026)


ANTX AN2 Therapeutics Inc ANTX
22 GF Score
Price $4.70
! 4 Warning Signs
View Full Analysis

What is AN2 Therapeutics Operating Margin %?

AN2 Therapeutics ANTX -2.69% 22 Operating Margin % is 0.00% as of Mar. 2026. GuruFocus rates ANTX with a GF Score™ of 22/100. The stock has 4 warning signs investors should review. Among 940 Biotechnology companies, AN2 Therapeutics ranks worse than 106382.87% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. AN2 Therapeutics's Operating Income for the three months ended in Mar. 2026 was $-10.55 Mil. AN2 Therapeutics's Revenue for the three months ended in Mar. 2026 was $0.00 Mil. Therefore, AN2 Therapeutics's Operating Margin % for the quarter that ended in Mar. 2026 was 0.00%.

The historical rank and industry rank for AN2 Therapeutics's Operating Margin % or its related term are showing as below:


ANTX's Operating Margin % is not ranked *
in the Biotechnology industry.
Industry Median: -86.83
* Ranked among companies with meaningful Operating Margin % only.

AN2 Therapeutics's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

AN2 Therapeutics's Operating Income for the three months ended in Mar. 2026 was $-10.55 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-37.12 Mil.


AN2 Therapeutics  (NAS:ANTX) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


AN2 Therapeutics Operating Margin % Related Terms


AN2 Therapeutics Operating Margin % Historical Data

* Premium members only.

The historical data trend for AN2 Therapeutics's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

AN2 Therapeutics Operating Margin % Chart

AN2 Therapeutics Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial 0.00 0.00 0.00 0.00 0.00

AN2 Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

ANTX vs OKUR, KRRO, LENZ: Operating Margin % Comparison

For the Biotechnology subindustry, AN2 Therapeutics's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


AN2 Therapeutics Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, AN2 Therapeutics's Operating Margin % distribution charts can be found below:

* The bar in red indicates where AN2 Therapeutics's Operating Margin % falls into.


ANTX
22GF Score
AN2 Therapeutics Inc ANTX
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

AN2 Therapeutics Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

AN2 Therapeutics's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-38.109 / 0
= %

AN2 Therapeutics's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-10.551 / 0
= %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of 0.00% mean?
AN2 Therapeutics (ANTX) has a Operating Margin % of 0.00% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on AN2 Therapeutics and its competitors. According to the industry distribution chart, AN2 Therapeutics ranks #999999 out of 940 companies in the Biotechnology industry.
Is AN2 Therapeutics' Operating Margin % too high?
AN2 Therapeutics' current Operating Margin % is 0.00%. Based on the distribution chart, AN2 Therapeutics ranks #999999 out of 940 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, AN2 Therapeutics has a GF Score™ of 22/100, reflecting its overall financial health beyond just this single metric.
How does AN2 Therapeutics' Operating Margin % compare to OKUR and KRRO?
According to the Biotechnology industry distribution chart, AN2 Therapeutics ranks #999999 out of 940 companies for Operating Margin %. This places AN2 Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on AN2 Therapeutics and its competitors. AN2 Therapeutics's current Operating Margin % is 0.00%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AN2 Therapeutics stock overvalued right now?
AN2 Therapeutics (ANTX) has a current Operating Margin % of 0.00%. The current Operating Margin % is 0.00%. AN2 Therapeutics' overall GF Score™ is 22/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For AN2 Therapeutics (ANTX), the current Operating Margin % is 0.00% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

AN2 Therapeutics Business Description

Address 1300 El Camino Real, Suite 100, Menlo Park, CA, USA, 94025
AN2 Therapeutics Inc is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from its boron chemistry platform. The company has a pipeline of boron-based compounds in development for Chagas disease, non-tuberculous mycobacterial (NTM) and melioidosis, along with early-stage programs focused on targets in infectious diseases and oncology. Product candidate AN2-502998 Epetraborole.
22GF Score

Get the complete analysis for ANTX

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$4.70
Price