CNTB (Connect Biopharma Holdings) Operating Margin %: -11,601.78% (As of Mar. 2026)


CNTB Connect Biopharma Holdings Ltd CNTB
7 GF Score
Price $2.13
! 3 Warning Signs
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What is Connect Biopharma Holdings Operating Margin %?

Connect Biopharma Holdings CNTB +1.44% 7 Operating Margin % is -11,601.78% as of Mar. 2026. GuruFocus rates CNTB with a GF Score™ of 7/100. The stock has 3 warning signs investors should review. Among 945 Biotechnology companies, Connect Biopharma Holdings ranks worse than 96.51% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Connect Biopharma Holdings's Operating Income for the three months ended in Mar. 2026 was $-19.61 Mil. Connect Biopharma Holdings's Revenue for the three months ended in Mar. 2026 was $0.17 Mil. Therefore, Connect Biopharma Holdings's Operating Margin % for the quarter that ended in Mar. 2026 was -11,601.78%.

The historical rank and industry rank for Connect Biopharma Holdings's Operating Margin % or its related term are showing as below:

CNTB' s Operating Margin % Range Over the Past 10 Years
Min: -90740.63   Med: -45413.44   Max: -86.24
Current: -28426.61


CNTB's Operating Margin % is ranked worse than
96.51% of 945 companies
in the Biotechnology industry
Industry Median: -86.89 vs CNTB: -28426.61

Connect Biopharma Holdings's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

Connect Biopharma Holdings's Operating Income for the three months ended in Mar. 2026 was $-19.61 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-66.23 Mil.


Connect Biopharma Holdings  (NAS:CNTB) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Connect Biopharma Holdings Operating Margin % Related Terms


Connect Biopharma Holdings Operating Margin % Historical Data

* Premium members only.

The historical data trend for Connect Biopharma Holdings's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Connect Biopharma Holdings Operating Margin % Chart

Connect Biopharma Holdings Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial 0.00 0.00 0.00 -86.24 -90,740.63

Connect Biopharma Holdings Quarterly Data
Dec19 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 -27,966.67 -110,481.25 0.00 -11,601.78

CNTB vs ANTX, VXRT, TTRX: Operating Margin % Comparison

For the Biotechnology subindustry, Connect Biopharma Holdings's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Connect Biopharma Holdings Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Connect Biopharma Holdings's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Connect Biopharma Holdings's Operating Margin % falls into.


CNTB
7GF Score
Connect Biopharma Holdings Ltd CNTB
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Connect Biopharma Holdings Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Connect Biopharma Holdings's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-58.074 / 0.064
=-90,740.63 %

Connect Biopharma Holdings's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-19.607 / 0.169
=-11,601.78 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -11,601.78% mean?
Connect Biopharma Holdings (CNTB) has a Operating Margin % of -11,601.78% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Connect Biopharma Holdings and its competitors. According to the industry distribution chart, Connect Biopharma Holdings ranks #912 out of 945 companies in the Biotechnology industry, placing it in the top 96.5%.
Is Connect Biopharma Holdings' Operating Margin % too high?
Connect Biopharma Holdings' current Operating Margin % is -11,601.78%. Based on the distribution chart, Connect Biopharma Holdings ranks #912 out of 945 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Connect Biopharma Holdings has a GF Score™ of 7/100, reflecting its overall financial health beyond just this single metric.
How does Connect Biopharma Holdings' Operating Margin % compare to ANTX and VXRT?
According to the Biotechnology industry distribution chart, Connect Biopharma Holdings ranks #912 out of 945 companies for Operating Margin %. This places Connect Biopharma Holdings in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Connect Biopharma Holdings and its competitors. Connect Biopharma Holdings's current Operating Margin % is -11,601.78%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Connect Biopharma Holdings stock overvalued right now?
Connect Biopharma Holdings (CNTB) has a current Operating Margin % of -11,601.78%. The current Operating Margin % is -11,601.78%. Connect Biopharma Holdings' overall GF Score™ is 7/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Connect Biopharma Holdings (CNTB), the current Operating Margin % is -11,601.78% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Connect Biopharma Holdings Business Description

Address 3580 Carmel Mountain Road, Suite 200, San Diego, CA, USA, 92130
Connect Biopharma Holdings Ltd is a clinical-stage biopharmaceutical company dedicated to transforming care for asthma and chronic obstructive pulmonary disease (COPD). The company is advancing rademikibart, a next-generation antibody designed to target interleukin-4-receptor alpha. It is currently conducting clinical studies of rademikibart for the treatment of acute exacerbations of asthma and COPD. The company operates in one operating segment: treatment of respiratory diseases.
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