Advicenne (FRA:3MM) Operating Margin %: -123.45% (As of Dec. 2025)


FRA:3MM Advicenne SA FRA:3MM
28 GF Score
Price €1.00
GF Value €1.99
Valuation Possible Value Trap
! 4 Warning Signs
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What is Advicenne Operating Margin %?

Advicenne FRA:3MM -9.18% 28 Operating Margin % is -123.45% as of Dec. 2025. GuruFocus rates FRA:3MM with a GF Score™ of 28/100 and a GF Value™ of €1.99 (Possible Value Trap). The stock has 4 warning signs investors should review. Among 945 Biotechnology companies, Advicenne ranks worse than 55.13% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Advicenne's Operating Income for the six months ended in Dec. 2025 was €-3.98 Mil. Advicenne's Revenue for the six months ended in Dec. 2025 was €3.22 Mil. Therefore, Advicenne's Operating Margin % for the quarter that ended in Dec. 2025 was -123.45%.

Good Sign:

Advicenne SA operating margin is expanding. Margin expansion is usually a good sign.

The historical rank and industry rank for Advicenne's Operating Margin % or its related term are showing as below:

FRA:3MM' s Operating Margin % Range Over the Past 10 Years
Min: -3031.48   Med: -470.22   Max: -139.13
Current: -139.13


FRA:3MM's Operating Margin % is ranked worse than
55.13% of 945 companies
in the Biotechnology industry
Industry Median: -86.77 vs FRA:3MM: -139.13

Advicenne's 5-Year Average Operating Margin % Growth Rate was 27.50% per year.

Advicenne's Operating Income for the six months ended in Dec. 2025 was €-3.98 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Dec. 2025 was €-8.36 Mil.


Advicenne  (FRA:3MM) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Advicenne Operating Margin % Related Terms


Advicenne Operating Margin % Historical Data

* Premium members only.

The historical data trend for Advicenne's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Advicenne Operating Margin % Chart

Advicenne Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -462.70 -276.77 -145.24 -182.16 -139.13

Advicenne Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -122.87 -190.82 -173.68 -157.30 -123.45

FRA:3MM vs VRTX, REGN, ALNY: Operating Margin % Comparison

For the Biotechnology subindustry, Advicenne's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Advicenne Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Advicenne's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Advicenne's Operating Margin % falls into.


FRA:3MM
28GF Score
Advicenne SA FRA:3MM
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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Advicenne Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Advicenne's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-8.356 / 6.006
=-139.13 %

Advicenne's Operating Margin % for the quarter that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (Q: Dec. 2025 ) / Revenue (Q: Dec. 2025 )
=-3.98 / 3.224
=-123.45 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -123.45% mean?
Advicenne (FRA:3MM) has a Operating Margin % of -123.45% as of Dec. 2025. Operating margin is the ratio of total operating income to net sales. View historical data on Advicenne and its competitors. According to the industry distribution chart, Advicenne ranks #521 out of 945 companies in the Biotechnology industry, placing it in the top 55.1%.
Is Advicenne's Operating Margin % too high?
Advicenne's current Operating Margin % is -123.45%. Based on the distribution chart, Advicenne ranks #521 out of 945 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Advicenne has a GF Score™ of 28/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Advicenne's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Advicenne ranks #521 out of 945 companies for Operating Margin %. This places Advicenne in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Advicenne and its competitors. Advicenne's current Operating Margin % is -123.45%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Advicenne stock overvalued right now?
Based on GuruFocus' analysis, Advicenne (FRA:3MM) is currently considered Possible Value Trap. The stock's GF Value™ is €1.99, compared to a current price of €1.00 — trading 49.8% below its estimated fair value. The current Operating Margin % is -123.45%. Advicenne's overall GF Score™ is 28/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Advicenne (FRA:3MM), the current Operating Margin % is -123.45% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Advicenne (FRA:3MM) Overvalued in 2026?

Based on GuruFocus' analysis, Advicenne stock appears to be undervalued. The current stock price of €1.00 is trading 49.8% below its estimated GF Value™ of €1.99. GuruFocus considers Advicenne to be Possible Value Trap.

Key valuation signals for FRA:3MM:

  • Operating Margin %: -123.45%
  • GF Value™: €1.99 vs. price of €1.00 (49.8% below fair value)
  • GF Score™: 28/100 with 4 warning signs

No single metric tells the full story. See the FRA:3MM stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Advicenne Business Description

Other Exchanges ALDVI:France
Address 2, rue Briconnet, Nimes, FRA, F-30 000
Advicenne SA is a late-stage biopharmaceutical company. The company is engaged in the development of paediatric friendly therapeutics for the treatment of orphan renal diseases and niche neurology indications. Its goal is to improve the lives of patients from early childhood through adulthood.
28GF Score

Get the complete analysis for FRA:3MM

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€1.00
Price
€1.99
GF Value