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The historical rank and industry rank for Alphamab Oncology's Operating Margin % or its related term are showing as below:
HKSE:09966'
s Operating Margin % Range Over the Past 10 Years
Min: -275.29 Med: -139.66 Max: 17.78
Current: -24.14
HKSE:09966's Operating Margin % is ranked better than 61.44% of 944
companies
in the Biotechnology industry
Industry Median: -84.515
vs HKSE:09966: -24.14
Alphamab Oncology's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.
Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
Alphamab Oncology Operating Margin % Related Terms
Alphamab Oncology Operating Margin % Historical Data
* Premium members only.
The historical data trend for Alphamab Oncology's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
HKSE:09966 vs VRTX, REGN, RVMD: Operating Margin % Comparison
For the Biotechnology subindustry, Alphamab Oncology's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Alphamab Oncology Operating Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Alphamab Oncology's Operating Margin % distribution charts can be found below:
* The bar in red indicates where Alphamab Oncology's Operating Margin % falls into.
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
Alphamab Oncology's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Alphamab Oncology (HKSE:09966) has a Operating Margin % of -58.28% as of Dec. 2025. Operating margin is the ratio of total operating income to net sales. View historical data on Alphamab Oncology and its competitors. According to the industry distribution chart, Alphamab Oncology ranks #364 out of 944 companies in the Biotechnology industry, placing it in the top 38.6%.
Is Alphamab Oncology's Operating Margin % too high?
Alphamab Oncology's current Operating Margin % is -58.28%. Based on the distribution chart, Alphamab Oncology ranks #364 out of 944 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Alphamab Oncology has a GF Score™ of 55/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Alphamab Oncology's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Alphamab Oncology ranks #364 out of 944 companies for Operating Margin %. This puts Alphamab Oncology in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Alphamab Oncology and its competitors. Alphamab Oncology's current Operating Margin % is -58.28%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Alphamab Oncology stock overvalued right now?
Based on GuruFocus' analysis, Alphamab Oncology (HKSE:09966) is currently considered Fairly Valued. The stock's GF Value™ is HK$7.81, compared to a current price of HK$8.35 — trading 6.9% above its estimated fair value. The current Operating Margin % is -58.28%. Alphamab Oncology's overall GF Score™ is 55/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Alphamab Oncology (HKSE:09966), the current Operating Margin % is -58.28% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Alphamab Oncology (HKSE:09966) Overvalued in 2026?
Based on GuruFocus' analysis, Alphamab Oncology stock appears to be overvalued.
The current stock price of HK$8.35 is trading 6.9% above its estimated GF Value™ of HK$7.81.
GuruFocus considers Alphamab Oncology to be Fairly Valued.
Key valuation signals for HKSE:09966:
Operating Margin %: -58.28%
GF Value™: HK$7.81 vs. price of HK$8.35 (6.9% above fair value)
No single metric tells the full story. See the HKSE:09966 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Alphamab Oncology is a biopharmaceutical company in China with a fully integrated proprietary technology platform in ADCs, bispecific antibodies, and multifunctional protein engineering. The Company is principally engaged in the research and development, manufacturing, and commercialisation of biologics of oncology. It delivers therapeutic biologics by applying its drug discovery and development capabilities. Its product portfolio includes Envafolimab (KN035), KN026, JSKN003, JSKN016, JSKN033, JSKN022, JSKN027, JSKN021, KN019, and KN046.
55GF Score
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Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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