Innate PharmaIPHA -0.05%41 Operating Margin % is -2,508.42% as of Dec. 2025. GuruFocus rates IPHA with a GF Score™ of 41/100 and a GF Value™ of $0.16 (Significantly Overvalued). The stock has 7 warning signs investors should review. Among 945 Biotechnology companies, Innate Pharma ranks worse than 84.23% on this metric.
Operating Margin % is calculated as Operating Income divided by its Revenue. Innate Pharma's Operating Income for the
six
months ended in Dec. 2025 was $-32.79 Mil. Innate Pharma's Revenue for the
six
months ended in Dec. 2025 was $1.31 Mil. Therefore, Innate Pharma's Operating Margin % for the quarter that ended in Dec. 2025 was -2,508.42%.
The historical rank and industry rank for Innate Pharma's Operating Margin % or its related term are showing as below:
IPHA'
s Operating Margin % Range Over the Past 10 Years
Min: -1916.94 Med: -28.77 Max: 13.48
Current: -1916.94
IPHA's Operating Margin % is ranked worse than 84.23% of 945
companies
in the Biotechnology industry
Industry Median: -86.77
vs IPHA: -1916.94
Innate Pharma's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.
Innate Pharma's Operating Income for the
six
months ended in Dec. 2025 was $-32.79 Mil.
Its Operating Income for the trailing twelve months (TTM) ended in Dec. 2025 was $-62.11 Mil.
Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
Innate Pharma Operating Margin % Related Terms
Innate Pharma Operating Margin % Historical Data
* Premium members only.
The historical data trend for Innate Pharma's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
IPHA vs VRTX, REGN, ALNY: Operating Margin % Comparison
For the Biotechnology subindustry, Innate Pharma's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Innate Pharma Operating Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Innate Pharma's Operating Margin % distribution charts can be found below:
* The bar in red indicates where Innate Pharma's Operating Margin % falls into.
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
Innate Pharma's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
What does a Operating Margin % of -2,508.42% mean?
Innate Pharma (IPHA) has a Operating Margin % of -2,508.42% as of Dec. 2025. Operating margin is the ratio of total operating income to net sales. View historical data on Innate Pharma and its competitors. According to the industry distribution chart, Innate Pharma ranks #796 out of 945 companies in the Biotechnology industry, placing it in the top 84.2%.
Is Innate Pharma's Operating Margin % too high?
Innate Pharma's current Operating Margin % is -2,508.42%. Based on the distribution chart, Innate Pharma ranks #796 out of 945 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Innate Pharma has a GF Score™ of 41/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Innate Pharma's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Innate Pharma ranks #796 out of 945 companies for Operating Margin %. This places Innate Pharma in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Innate Pharma and its competitors. Innate Pharma's current Operating Margin % is -2,508.42%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Innate Pharma stock overvalued right now?
Based on GuruFocus' analysis, Innate Pharma (IPHA) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.16, compared to a current price of $1.90 — trading 1086.9% above its estimated fair value. The current Operating Margin % is -2,508.42%. Innate Pharma's overall GF Score™ is 41/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Innate Pharma (IPHA), the current Operating Margin % is -2,508.42% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Innate Pharma (IPHA) Overvalued in 2026?
Based on GuruFocus' analysis, Innate Pharma stock appears to be overvalued.
The current stock price of $1.90 is trading 1086.9% above its estimated GF Value™ of $0.16.
GuruFocus considers Innate Pharma to be Significantly Overvalued.
Key valuation signals for IPHA:
Operating Margin %: -2,508.42%
GF Value™: $0.16 vs. price of $1.90 (1086.9% above fair value)
No single metric tells the full story. See the IPHA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Innate Pharma SA is a clinical-stage biotechnology company. It is engaged in developing immunotherapies for cancer patients. The company's approach includes therapeutic modalities such as monoclonal antibodies, multispecific NK cell engagers through its ANKET platform, and antibody-drug conjugates (ADC). Its portfolio includes lacutamab, which is being studied for cutaneous T-cell lymphomas and peripheral T-cell lymphomas, and monalizumab, which is being developed in collaboration with AstraZeneca for non-small cell lung cancer. The company's revenue mainly consists of revenues from collaboration and licensing agreements and government financing for research expenditure in the form of research tax credits, as well as other grants.
41GF Score
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