ADR120S (TSE:3750) Operating Margin %: -1,753.67% (As of Mar. 2026)


TSE:3750 ADR120S Inc TSE:3750
39 GF Score
Price 円797.00
GF Value 円40.77
Valuation Significantly Overvalued
! 9 Warning Signs
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What is ADR120S Operating Margin %?

ADR120S TSE:3750 +1.53% 39 Operating Margin % is -1,753.67% as of Mar. 2026. GuruFocus rates TSE:3750 with a GF Score™ of 39/100 and a GF Value™ of 円40.77 (Significantly Overvalued). The stock has 9 warning signs investors should review. Among 945 Biotechnology companies, ADR120S ranks worse than 83.7% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. ADR120S's Operating Income for the six months ended in Mar. 2026 was 円-573.59 Mil. ADR120S's Revenue for the six months ended in Mar. 2026 was 円32.71 Mil. Therefore, ADR120S's Operating Margin % for the quarter that ended in Mar. 2026 was -1,753.67%.

Warning Sign:

ADR120S Inc operating margin has been in a 5-year decline. The average rate of decline per year is -114.6%.

The historical rank and industry rank for ADR120S's Operating Margin % or its related term are showing as below:

TSE:3750' s Operating Margin % Range Over the Past 10 Years
Min: -1777.23   Med: -35.83   Max: 24.98
Current: -1777.23


TSE:3750's Operating Margin % is ranked worse than
83.7% of 945 companies
in the Biotechnology industry
Industry Median: -86.77 vs TSE:3750: -1777.23

ADR120S's 5-Year Average Operating Margin % Growth Rate was -114.60% per year.

ADR120S's Operating Income for the six months ended in Mar. 2026 was 円-573.59 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was 円-906.17 Mil.


ADR120S  (TSE:3750) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


ADR120S Operating Margin % Related Terms


ADR120S Operating Margin % Historical Data

* Premium members only.

The historical data trend for ADR120S's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

ADR120S Operating Margin % Chart

ADR120S Annual Data
Trend Mar17 Mar18 Mar19 Mar20 Mar21 Mar22 Mar23 Mar24 Mar25 Mar26
Operating Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -34.62 -37.04 -49.52 -660.28 -1,777.23

ADR120S Semi-Annual Data
Sep16 Mar17 Sep17 Mar18 Sep18 Mar19 Sep19 Mar20 Sep20 Mar21 Sep21 Mar22 Sep22 Mar23 Sep23 Mar24 Sep24 Mar25 Sep25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -59.99 -445.46 -1,298.59 -1,819.38 -1,753.67

TSE:3750 vs VRTX, REGN, ALNY: Operating Margin % Comparison

For the Biotechnology subindustry, ADR120S's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


ADR120S Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, ADR120S's Operating Margin % distribution charts can be found below:

* The bar in red indicates where ADR120S's Operating Margin % falls into.


TSE:3750
39GF Score
ADR120S Inc TSE:3750
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

ADR120S Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

ADR120S's Operating Margin % for the fiscal year that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (A: Mar. 2026 ) / Revenue (A: Mar. 2026 )
=-906.173 / 50.988
=-1,777.23 %

ADR120S's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-573.591 / 32.708
=-1,753.67 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -1,753.67% mean?
ADR120S (TSE:3750) has a Operating Margin % of -1,753.67% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on ADR120S and its competitors. According to the industry distribution chart, ADR120S ranks #791 out of 945 companies in the Biotechnology industry, placing it in the top 83.7%.
Is ADR120S's Operating Margin % too high?
ADR120S's current Operating Margin % is -1,753.67%. Based on the distribution chart, ADR120S ranks #791 out of 945 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, ADR120S has a GF Score™ of 39/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does ADR120S's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, ADR120S ranks #791 out of 945 companies for Operating Margin %. This places ADR120S in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on ADR120S and its competitors. ADR120S's current Operating Margin % is -1,753.67%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ADR120S stock overvalued right now?
Based on GuruFocus' analysis, ADR120S (TSE:3750) is currently considered Significantly Overvalued. The stock's GF Value™ is 円40.77, compared to a current price of 円797.00 — trading 1854.9% above its estimated fair value. The current Operating Margin % is -1,753.67%. ADR120S's overall GF Score™ is 39/100 with 9 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For ADR120S (TSE:3750), the current Operating Margin % is -1,753.67% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is ADR120S (TSE:3750) Overvalued in 2026?

Based on GuruFocus' analysis, ADR120S stock appears to be overvalued. The current stock price of 円797.00 is trading 1854.9% above its estimated GF Value™ of 円40.77. GuruFocus considers ADR120S to be Significantly Overvalued.

Key valuation signals for TSE:3750:

  • Operating Margin %: -1,753.67%
  • GF Value™: 円40.77 vs. price of 円797.00 (1854.9% above fair value)
  • GF Score™: 39/100 with 9 warning signs

No single metric tells the full story. See the TSE:3750 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


ADR120S Business Description

Address 1-1-1 Otemachi, Otemachi Park Building, Chiyoda-ku, Tokyo, JPN, 100-0004
ADR120S Inc developing a new clinical approach to cell therapy to provide medical care to patients by providing medical care that responds to unmet medical needs based on its regenerative medicine. Its product pipeline includes Habeo; ECCO-50 and others.
39GF Score

Get the complete analysis for TSE:3750

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円797.00
Price
円40.77
GF Value