ReproCELLorp (TSE:4978) Operating Margin %: -20.39% (As of Dec. 2025)


TSE:4978 ReproCELL Incorp TSE:4978
58 GF Score
Price 円132.00
GF Value 円151.20
Valuation Modestly Undervalued
! 3 Warning Signs
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What is ReproCELLorp Operating Margin %?

ReproCELLorp TSE:4978 +10.00% 58 Operating Margin % is -20.39% as of Dec. 2025. GuruFocus rates TSE:4978 with a GF Score™ of 58/100 and a GF Value™ of 円151.20 (Modestly Undervalued). The stock has 3 warning signs investors should review. Among 944 Biotechnology companies, ReproCELLorp ranks better than 57.31% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. ReproCELLorp's Operating Income for the three months ended in Dec. 2025 was 円-130 Mil. ReproCELLorp's Revenue for the three months ended in Dec. 2025 was 円636 Mil. Therefore, ReproCELLorp's Operating Margin % for the quarter that ended in Dec. 2025 was -20.39%.

Good Sign:

ReproCELL Incorp operating margin is expanding. Margin expansion is usually a good sign.

The historical rank and industry rank for ReproCELLorp's Operating Margin % or its related term are showing as below:

TSE:4978' s Operating Margin % Range Over the Past 10 Years
Min: -110.75   Med: -55.14   Max: -4.38
Current: -38.51


TSE:4978's Operating Margin % is ranked better than
57.31% of 944 companies
in the Biotechnology industry
Industry Median: -86.83 vs TSE:4978: -38.51

ReproCELLorp's 5-Year Average Operating Margin % Growth Rate was 22.90% per year.

ReproCELLorp's Operating Income for the three months ended in Dec. 2025 was 円-130 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Dec. 2025 was 円-860 Mil.


ReproCELLorp  (TSE:4978) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


ReproCELLorp Operating Margin % Related Terms


ReproCELLorp Operating Margin % Historical Data

* Premium members only.

The historical data trend for ReproCELLorp's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

ReproCELLorp Operating Margin % Chart

ReproCELLorp Annual Data
Trend Mar17 Mar18 Mar19 Mar20 Mar21 Mar22 Mar23 Mar24 Mar25 Mar26
Operating Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -28.96 -12.06 -16.87 -4.38 -38.51

ReproCELLorp Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 5.48 -61.17 -51.30 -20.39 -29.47

TSE:4978 vs VRTX, REGN, ALNY: Operating Margin % Comparison

For the Biotechnology subindustry, ReproCELLorp's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


ReproCELLorp Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, ReproCELLorp's Operating Margin % distribution charts can be found below:

* The bar in red indicates where ReproCELLorp's Operating Margin % falls into.


TSE:4978
58GF Score
ReproCELL Incorp TSE:4978
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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ReproCELLorp Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

ReproCELLorp's Operating Margin % for the fiscal year that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (A: Mar. 2026 ) / Revenue (A: Mar. 2026 )
=-860.064 / 2233.518
=-38.51 %

ReproCELLorp's Operating Margin % for the quarter that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (Q: Dec. 2025 ) / Revenue (Q: Dec. 2025 )
=-129.612 / 635.724
=-20.39 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -20.39% mean?
ReproCELLorp (TSE:4978) has a Operating Margin % of -20.39% as of Dec. 2025. Operating margin is the ratio of total operating income to net sales. View historical data on ReproCELLorp and its competitors. According to the industry distribution chart, ReproCELLorp ranks #403 out of 944 companies in the Biotechnology industry, placing it in the top 42.7%.
Is ReproCELLorp's Operating Margin % too high?
ReproCELLorp's current Operating Margin % is -20.39%. Based on the distribution chart, ReproCELLorp ranks #403 out of 944 companies in the Biotechnology industry, which is above the industry midpoint. Overall, ReproCELLorp has a GF Score™ of 58/100 and is considered Modestly Undervalued, reflecting its overall financial health beyond just this single metric.
How does ReproCELLorp's Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, ReproCELLorp ranks #403 out of 944 companies for Operating Margin %. This puts ReproCELLorp in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on ReproCELLorp and its competitors. ReproCELLorp's current Operating Margin % is -20.39%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ReproCELLorp stock overvalued right now?
Based on GuruFocus' analysis, ReproCELLorp (TSE:4978) is currently considered Modestly Undervalued. The stock's GF Value™ is 円151.20, compared to a current price of 円132.00 — trading 12.7% below its estimated fair value. The current Operating Margin % is -20.39%. ReproCELLorp's overall GF Score™ is 58/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For ReproCELLorp (TSE:4978), the current Operating Margin % is -20.39% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is ReproCELLorp (TSE:4978) Overvalued in 2026?

Based on GuruFocus' analysis, ReproCELLorp stock appears to be undervalued. The current stock price of 円132.00 is trading 12.7% below its estimated GF Value™ of 円151.20. GuruFocus considers ReproCELLorp to be Modestly Undervalued.

Key valuation signals for TSE:4978:

  • Operating Margin %: -20.39%
  • GF Value™: 円151.20 vs. price of 円132.00 (12.7% below fair value)
  • GF Score™: 58/100 with 3 warning signs

No single metric tells the full story. See the TSE:4978 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


ReproCELLorp Business Description

Address KDX Shin-Yokohama 381 Bldg. 9F, 3-8-11, Shin-Yokohama, Kohoku-ku, Kanagawa, Yokohama, JPN, 222-0033
ReproCELL Incorp is one of the leading stem cell research company in Japan. The company provides stem cell services, predictive drug discovery services, tissue services, and molecular services.
58GF Score

Get the complete analysis for TSE:4978

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円132.00
Price
円151.20
GF Value