Avalo TherapeuticsAVTX +1.11%23 PB Ratio is 6.56 as of Jun. 26, 2026, which is 1% below its 10-year median of 6.60. GuruFocus rates AVTX with a GF Score™ of 23/100 and a GF Value™ of $0.03 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 1,232 Biotechnology companies, Avalo Therapeutics ranks worse than 78% on this metric.
The historical rank and industry rank for Avalo Therapeutics's PB Ratio or its related term are showing as below:
AVTX'
s PB Ratio Range Over the Past 10 Years
Min: 0.33 Med: 6.6 Max: 2524.27
Current: 6.57
During the past 13 years, Avalo Therapeutics's highest PB Ratio was 2524.27. The lowest was 0.33. And the median was 6.60.
AVTX's PB Ratio is ranked worse than 78% of 1232
companies
in the Biotechnology industry
Industry Median: 2.8
vs AVTX: 6.57
During the past 12 months, Avalo Therapeutics's average Book Value Per Share Growth Rate was -75.50% per year.
During the past 13 years, the highest 3-Year average Book Value Per Share Growth Rate of Avalo Therapeutics was 333.20% per year. The lowest was -88.10% per year. And the median was -62.45% per year.
Back to Basics: PB Ratio
Avalo Therapeutics (NAS:AVTX) PB Ratio Explanation
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
Avalo Therapeutics PB Ratio Related Terms
Avalo Therapeutics PB Ratio Historical Data
* Premium members only.
The historical data trend for Avalo Therapeutics's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Avalo Therapeutics's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Avalo Therapeutics PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Avalo Therapeutics's PB Ratio distribution charts can be found below:
* The bar in red indicates where Avalo Therapeutics's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
Avalo Therapeutics (AVTX) has a PB Ratio of 6.56 as of Jun. 26, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Avalo Therapeutics and its competitors. This is near median its historical median of 6.60. Over the past decade, Avalo Therapeutics' PB Ratio has ranged from 0.33 to 2,524.27. According to the industry distribution chart, Avalo Therapeutics ranks #961 out of 1232 companies in the Biotechnology industry, placing it in the top 78%.
Is Avalo Therapeutics' PB Ratio too high?
Avalo Therapeutics' current PB Ratio of 6.56 is near median its 10-year median of 6.60. Over the past 10 years, this metric has ranged from a low of 0.33 to a high of 2,524.27. The Biotechnology industry median PB Ratio is 2.80. Avalo Therapeutics' value of 6.56 is 134.3% above this industry median. Based on the distribution chart, Avalo Therapeutics ranks #961 out of 1232 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Avalo Therapeutics has a GF Score™ of 23/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Avalo Therapeutics' PB Ratio compare to EVMN and TBPH?
According to the Biotechnology industry distribution chart, Avalo Therapeutics ranks #961 out of 1232 companies for PB Ratio. This places Avalo Therapeutics in the lower half of its industry. The industry median PB Ratio is 2.80. Avalo Therapeutics' value of 6.56 is 134.3% above this benchmark. Historically, Avalo Therapeutics' own PB Ratio has ranged from 0.33 to 2,524.27 over the past decade. While the company's 10-year median is 6.60 vs. the industry median of 2.80, Avalo Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.80, based on 1,232 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Avalo Therapeutics's current PB Ratio of 6.56 is 134.3% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Avalo Therapeutics and its competitors. For the Biotechnology industry, the median PB Ratio is 2.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Avalo Therapeutics's current PB Ratio is 6.56, which is near median its own 10-year median of 6.60. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Avalo Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Avalo Therapeutics (AVTX) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.03, compared to a current price of $18.20 — trading 60566.7% above its estimated fair value. The current PB Ratio is 6.56, which is near median its 10-year median of 6.60 and 134.3% above the Biotechnology industry median of 2.80. Avalo Therapeutics' overall GF Score™ is 23/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For Avalo Therapeutics (AVTX), the current PB Ratio is 6.56 as of Jun. 26, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Avalo Therapeutics (AVTX) Overvalued in 2026?
Based on GuruFocus' analysis, Avalo Therapeutics stock appears to be overvalued.
The current stock price of $18.20 is trading 60566.7% above its estimated GF Value™ of $0.03.
GuruFocus considers Avalo Therapeutics to be Significantly Overvalued.
Key valuation signals for AVTX:
PB Ratio: 6.56 (near median its 10-year median of 6.60)
GF Value™: $0.03 vs. price of $18.20 (60566.7% above fair value)
Industry Position: 134.3% above the Biotechnology median (#961 of 1232)
No single metric tells the full story. See the AVTX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Avalo Therapeutics Inc is a clinical stage biotechnology company fully dedicated to developing IL-1B-based treatments for immune-mediated inflammatory diseases. The company's asset is Abdakibart (AVTX-009) an anti-IL-1B monoclonal antibody ("mAb"), targeting inflammatory diseases. Avalos pipeline also includes quisovalimab (anti-LIGHT mAb) and AVTX-008 (BTLA agonist fusion protein), AVTX-006 and AVTX-913.
23GF Score
Get the complete analysis for AVTX
PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
AVTX has been successfully added to your 
