Gain TherapeuticsGANX -1.15%31 PB Ratio is 5.21 as of Jun. 26, 2026, which is 110% above its 10-year median of 2.48. GuruFocus rates GANX with a GF Score™ of 31/100. The stock has 2 warning signs investors should review. Among 1,232 Biotechnology companies, Gain Therapeutics ranks worse than 72.65% on this metric.
Gain Therapeutics Inc stock PB Ratio (=5.27) is close to 2-year high of 5.34.
The historical rank and industry rank for Gain Therapeutics's PB Ratio or its related term are showing as below:
GANX'
s PB Ratio Range Over the Past 10 Years
Min: 1 Med: 2.48 Max: 24.72
Current: 5.21
During the past 8 years, Gain Therapeutics's highest PB Ratio was 24.72. The lowest was 1.00. And the median was 2.48.
GANX's PB Ratio is ranked worse than 72.65% of 1232
companies
in the Biotechnology industry
Industry Median: 2.8
vs GANX: 5.21
During the past 12 months, Gain Therapeutics's average Book Value Per Share Growth Rate was 64.20% per year.
During the past 3 years, the average Book Value Per Share Growth Rate was -34.80% per year.
During the past 5 years, the average Book Value Per Share Growth Rate was -22.50% per year.
During the past 8 years, the highest 3-Year average Book Value Per Share Growth Rate of Gain Therapeutics was 12.40% per year. The lowest was -54.80% per year. And the median was -34.80% per year.
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
Gain Therapeutics PB Ratio Related Terms
Gain Therapeutics PB Ratio Historical Data
* Premium members only.
The historical data trend for Gain Therapeutics's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Gain Therapeutics's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Gain Therapeutics PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Gain Therapeutics's PB Ratio distribution charts can be found below:
* The bar in red indicates where Gain Therapeutics's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
Gain Therapeutics (GANX) has a PB Ratio of 5.21 as of Jun. 26, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Gain Therapeutics and its competitors. This is 110% above median its historical median of 2.48. Over the past decade, Gain Therapeutics' PB Ratio has ranged from 1.00 to 24.72. According to the industry distribution chart, Gain Therapeutics ranks #895 out of 1232 companies in the Biotechnology industry, placing it in the top 72.6%.
Is Gain Therapeutics' PB Ratio too high?
Gain Therapeutics' current PB Ratio of 5.21 is 110% above median its 10-year median of 2.48. Over the past 10 years, this metric has ranged from a low of 1.00 to a high of 24.72. The Biotechnology industry median PB Ratio is 2.80. Gain Therapeutics' value of 5.21 is 86.1% above this industry median. Based on the distribution chart, Gain Therapeutics ranks #895 out of 1232 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Gain Therapeutics has a GF Score™ of 31/100, reflecting its overall financial health beyond just this single metric.
How does Gain Therapeutics' PB Ratio compare to EXOZ and HYFT?
According to the Biotechnology industry distribution chart, Gain Therapeutics ranks #895 out of 1232 companies for PB Ratio. This places Gain Therapeutics in the lower half of its industry. The industry median PB Ratio is 2.80. Gain Therapeutics' value of 5.21 is 86.1% above this benchmark. Historically, Gain Therapeutics' own PB Ratio has ranged from 1.00 to 24.72 over the past decade. While the company's 10-year median is 2.48 vs. the industry median of 2.80, Gain Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.80, based on 1,232 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Gain Therapeutics's current PB Ratio of 5.21 is 86.1% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Gain Therapeutics and its competitors. For the Biotechnology industry, the median PB Ratio is 2.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Gain Therapeutics's current PB Ratio is 5.21, which is 110% above median its own 10-year median of 2.48. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Gain Therapeutics stock overvalued right now?
Gain Therapeutics (GANX) has a current PB Ratio of 5.21. The current PB Ratio is 5.21, which is 110% above median its 10-year median of 2.48 and 86.1% above the Biotechnology industry median of 2.80. Gain Therapeutics' overall GF Score™ is 31/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For Gain Therapeutics (GANX), the current PB Ratio is 5.21 as of Jun. 26, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Gain Therapeutics Inc is a clinical-stage biotechnology company developing novel small-molecule therapeutics to treat diseases across several therapeutic areas, including central nervous system (CNS) disorders, lysosomal storage disorders (LSDs), metabolic disorders, and other diseases that can be targeted through protein degradation, such as oncology. The Company's clinical stage product candidate, GT-02287, is being developed for the treatment of Parkinson's disease with and without GBA1 mutations. The Company generated an extensive preclinical data package providing evidence of the mechanism of action.
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