CLDI (Calidi Biotherapeutics) Return-on-Tangible-Equity: -378.01% (As of Mar. 2026)


CLDI Calidi Biotherapeutics Inc CLDI
12 GF Score
Price $0.15
! 1 Warning Sign
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What is Calidi Biotherapeutics Return-on-Tangible-Equity?

Calidi Biotherapeutics CLDI -5.70% 12 Return-on-Tangible-Equity is -378.01% as of Mar. 2026. GuruFocus rates CLDI with a GF Score™ of 12/100. The stock has 1 warning sign investors should review. Among 1,199 Biotechnology companies, Calidi Biotherapeutics ranks worse than 93.66% on this metric.

Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Calidi Biotherapeutics's annualized net income for the quarter that ended in Mar. 2026 was $-16.43 Mil. Calidi Biotherapeutics's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $4.35 Mil. Therefore, Calidi Biotherapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -378.01%.

The historical rank and industry rank for Calidi Biotherapeutics's Return-on-Tangible-Equity or its related term are showing as below:

CLDI' s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -752.16   Med: -752.16   Max: -391.25
Current: -391.25

During the past 6 years, Calidi Biotherapeutics's highest Return-on-Tangible-Equity was -391.25%. The lowest was -752.16%. And the median was -752.16%.

CLDI's Return-on-Tangible-Equity is ranked worse than
93.66% of 1199 companies
in the Biotechnology industry
Industry Median: -42.4 vs CLDI: -391.25

Calidi Biotherapeutics  (AMEX:CLDI) Return-on-Tangible-Equity Explanation

Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.


Be Aware

Net Income is used.

Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.


Calidi Biotherapeutics Return-on-Tangible-Equity Related Terms


Calidi Biotherapeutics Return-on-Tangible-Equity Historical Data

* Premium members only.

The historical data trend for Calidi Biotherapeutics's Return-on-Tangible-Equity can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Calidi Biotherapeutics Return-on-Tangible-Equity Chart

Calidi Biotherapeutics Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Return-on-Tangible-Equity
Get a 7-Day Free Trial 0.00 0.00 0.00 0.00 -752.16

Calidi Biotherapeutics Quarterly Data
Dec20 Dec21 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Return-on-Tangible-Equity Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -470.65 -525.22 -474.45 -303.91 -378.01

CLDI vs DCOY, CDT, ACUT: Return-on-Tangible-Equity Comparison

For the Biotechnology subindustry, Calidi Biotherapeutics's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Calidi Biotherapeutics Return-on-Tangible-Equity vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Calidi Biotherapeutics's Return-on-Tangible-Equity distribution charts can be found below:

* The bar in red indicates where Calidi Biotherapeutics's Return-on-Tangible-Equity falls into.


CLDI
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Calidi Biotherapeutics Inc CLDI
Return-on-Tangible-Equity is just one metric. See GF Score™, valuation, warning signs, and more.
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Calidi Biotherapeutics Return-on-Tangible-Equity Calculation

Calidi Biotherapeutics's annualized Return-on-Tangible-Equity for the fiscal year that ended in Dec. 2025 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets )/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=-19.906/( (1.534+3.759 )/ 2 )
=-19.906/2.6465
=-752.16 %

Calidi Biotherapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=-16.432/( (3.759+4.935)/ 2 )
=-16.432/4.347
=-378.01 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Mar. 2026) net income data. Return-on-Tangible-Equity is displayed in the 10-year financial page.

What does a Return-on-Tangible-Equity of -378.01% mean?
Calidi Biotherapeutics (CLDI) has a Return-on-Tangible-Equity of -378.01% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Calidi Biotherapeutics and its competitors. According to the industry distribution chart, Calidi Biotherapeutics ranks #1123 out of 1199 companies in the Biotechnology industry, placing it in the top 93.7%.
Is Calidi Biotherapeutics' Return-on-Tangible-Equity too high?
Calidi Biotherapeutics' current Return-on-Tangible-Equity is -378.01%. Based on the distribution chart, Calidi Biotherapeutics ranks #1123 out of 1199 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Calidi Biotherapeutics has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Calidi Biotherapeutics' Return-on-Tangible-Equity compare to DCOY and CDT?
According to the Biotechnology industry distribution chart, Calidi Biotherapeutics ranks #1123 out of 1199 companies for Return-on-Tangible-Equity. This places Calidi Biotherapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Calidi Biotherapeutics and its competitors. Calidi Biotherapeutics's current Return-on-Tangible-Equity is -378.01%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Calidi Biotherapeutics stock overvalued right now?
Calidi Biotherapeutics (CLDI) has a current Return-on-Tangible-Equity of -378.01%. The current Return-on-Tangible-Equity is -378.01%. Calidi Biotherapeutics' overall GF Score™ is 12/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Calidi Biotherapeutics (CLDI), the current Return-on-Tangible-Equity is -378.01% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Calidi Biotherapeutics Business Description

Address 4475 Executive Drive, Suite 200, San Diego, CA, USA, 92121
Calidi Biotherapeutics Inc is a biotechnology company pioneering the development of targeted therapies with the potential to deliver genetic medicines to distal sites of disease. The company's proprietary RedTail platform features an engineered enveloped oncolytic virus designed for systemic delivery and targeting of metastatic sites. Its technology is intended to shield the virus from immune clearance, allowing virotherapy to effectively reach tumor sites, induce tumor lysis, and deliver potent genetic medicine(s) to metastatic locations. Its product candidates include The RedTail for Metastatic Solid Tumors, CLD-101 for Recurrent HGG; CLD-201 for Solid Tumors, and CLD-101 (NeuroNova) for Newly Diagnosed High Grade Glioma.
12GF Score

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