MBX (MBX Biosciences) ROA %: -22.45% (As of Mar. 2026)


MBX MBX Biosciences Inc MBX
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What is MBX Biosciences ROA %?

MBX Biosciences MBX +4.07% 12 ROA % is -22.45% as of Mar. 2026. GuruFocus rates MBX with a GF Score™ of 12/100. The stock has 2 warning signs investors should review. Among 1,422 Biotechnology companies, MBX Biosciences ranks better than 55.98% on this metric.

ROA % is calculated as Net Income divided by its average Total Assets over a certain period of time. MBX Biosciences's annualized Net Income for the quarter that ended in Mar. 2026 was $-94.07 Mil. MBX Biosciences's average Total Assets over the quarter that ended in Mar. 2026 was $418.92 Mil. Therefore, MBX Biosciences's annualized ROA % for the quarter that ended in Mar. 2026 was -22.45%.

The historical rank and industry rank for MBX Biosciences's ROA % or its related term are showing as below:

MBX' s ROA % Range Over the Past 10 Years
Min: -57.96   Med: -42.75   Max: -25.24
Current: -25.24

During the past 4 years, MBX Biosciences's highest ROA % was -25.24%. The lowest was -57.96%. And the median was -42.75%.

MBX's ROA % is ranked better than
55.98% of 1422 companies
in the Biotechnology industry
Industry Median: -32.87 vs MBX: -25.24

MBX Biosciences  (NAS:MBX) ROA % Explanation

ROA % measures the rate of return on the total assets (shareholder equity plus liabilities). It measures a firm's efficiency at generating profits from shareholders' equity plus its liabilities. ROA % shows how well a company uses what it has to generate earnings. ROA %s can vary drastically across industries. Therefore, ROA % should not be used to compare companies in different industries. For retailers, a ROA % of higher than 5% is expected. For example, Wal-Mart (WMT) has a ROA % of about 8% as of 2012. For banks, ROA % is close to their interest spread. A bank’s ROA % is typically well under 2%.

Similar to ROE, ROA % is affected by profit margins and asset turnover. This can be seen from the Du Pont Formula:

ROA %(Q: Mar. 2026 )
=Net Income/Total Assets
=-94.068/418.9225
=(Net Income / Revenue)*(Revenue / Total Assets)
=(-94.068 / 0)*(0 / 418.9225)
=Net Margin %*Asset Turnover
=N/A %*0
=-22.45 %

Note: The Net Income data used here is four times the quarterly (Mar. 2026) net income data. The Revenue data used here is four times the quarterly (Mar. 2026) revenue data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Like ROE, ROA % is calculated with only 12 months data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. ROA % can be affected by events such as stock buyback or issuance, and by goodwill, a company's tax rate and its interest payment. ROA % may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).

Many analysts argue the higher return the better. Buffett states that really high ROA % may indicate vulnerability in the durability of the competitive advantage.

E.g. Raising $43b to take on KO is impossible, but $1.7b to take on Moody's is. Although Moody's ROA % and underlying economics is far superior to Coca Cola, the durability is far weaker because of lower entry cost.


MBX Biosciences ROA % Related Terms


MBX Biosciences ROA % Historical Data

* Premium members only.

The historical data trend for MBX Biosciences's ROA % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

MBX Biosciences ROA % Chart

MBX Biosciences Annual Data
Trend Dec22 Dec23 Dec24 Dec25
ROA %
-57.96 -50.38 -35.11 -26.61

MBX Biosciences Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROA % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only -37.13 -32.52 -27.38 -22.48 -22.45

MBX vs ARDX, INBX, MAZE: ROA % Comparison

For the Biotechnology subindustry, MBX Biosciences's ROA %, along with its competitors' market caps and ROA % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


MBX Biosciences ROA % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, MBX Biosciences's ROA % distribution charts can be found below:

* The bar in red indicates where MBX Biosciences's ROA % falls into.


MBX
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MBX Biosciences Inc MBX
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MBX Biosciences ROA % Calculation

MBX Biosciences's annualized ROA % for the fiscal year that ended in Dec. 2025 is calculated as:

ROA %=Net Income (A: Dec. 2025 )/( (Total Assets (A: Dec. 2024 )+Total Assets (A: Dec. 2025 ))/ count )
=-86.971/( (268.535+385.144)/ 2 )
=-86.971/326.8395
=-26.61 %

MBX Biosciences's annualized ROA % for the quarter that ended in Mar. 2026 is calculated as:

ROA %=Net Income (Q: Mar. 2026 )/( (Total Assets (Q: Dec. 2025 )+Total Assets (Q: Mar. 2026 ))/ count )
=-94.068/( (385.144+452.701)/ 2 )
=-94.068/418.9225
=-22.45 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROA %, the net income of the last fiscal year and the average total assets over the fiscal year are used. In calculating the quarterly data, the Net Income data used here is four times the quarterly (Mar. 2026) net income data. ROA % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROA % →
What does a ROA % of -22.45% mean?
MBX Biosciences (MBX) has a ROA % of -22.45% as of Mar. 2026. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on MBX Biosciences and its competitors. According to the industry distribution chart, MBX Biosciences ranks #626 out of 1422 companies in the Biotechnology industry, placing it in the top 44%.
Is MBX Biosciences' ROA % too high?
MBX Biosciences' current ROA % is -22.45%. Based on the distribution chart, MBX Biosciences ranks #626 out of 1422 companies in the Biotechnology industry, which is above the industry midpoint. Overall, MBX Biosciences has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does MBX Biosciences' ROA % compare to ARDX and INBX?
According to the Biotechnology industry distribution chart, MBX Biosciences ranks #626 out of 1422 companies for ROA %. This puts MBX Biosciences in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROA % for a Biotechnology company?
A good ROA % depends on the Biotechnology industry context. However, ROA % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROA % mean?
A high ROA % can signal that a stock is expensive relative to its fundamentals. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on MBX Biosciences and its competitors. MBX Biosciences's current ROA % is -22.45%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is MBX Biosciences stock overvalued right now?
MBX Biosciences (MBX) has a current ROA % of -22.45%. The current ROA % is -22.45%. MBX Biosciences' overall GF Score™ is 12/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROA % calculated?
ROA % is calculated from a company's financial statements. For MBX Biosciences (MBX), the current ROA % is -22.45% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

MBX Biosciences Business Description

Address 11711 N. Meridian Street, Suite 300, Carmel, IN, USA, 46032
MBX Biosciences Inc is a clinical stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. The company designed its proprietary Precision Endocrine Peptide, or PEP, platform to overcome the key limitations of unmodified and modified peptide therapies to improve clinical outcomes and simplify disease management for patients. Its PEPs are selectively engineered to have optimized pharmaceutical properties, including extended time-action profiles and consistent drug concentrations with low peak-to-trough concentration ratios, consistent exposure to target tissues, and less frequent dosing. Its product candidates include canvuparatide (MBX 2109), imapextide (MBX 1416), and MBX 4291.
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