TNGX (Tango Therapeutics) ROE % Adjusted to Book Value: -6.41% (As of Mar. 2026)

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TNGX Tango Therapeutics Inc TNGX
54 GF Score
Price $27.67
GF Value $9.92
Valuation Significantly Overvalued
! 4 Warning Signs
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What is Tango Therapeutics ROE % Adjusted to Book Value?

Tango Therapeutics TNGX +2.22% 54 ROE % Adjusted to Book Value is -6.41% as of Mar. 2026. GuruFocus rates TNGX with a GF Score™ of 54/100 and a GF Value™ of $9.92 (Significantly Overvalued). The stock has 4 warning signs investors should review.

Tango Therapeutics's ROE % for the quarter that ended in Mar. 2026 was -49.36%. Tango Therapeutics's PB Ratio for the quarter that ended in Mar. 2026 was 7.70. Tango Therapeutics's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -6.41%.


Tango Therapeutics ROE % Adjusted to Book Value Related Terms


Tango Therapeutics ROE % Adjusted to Book Value Historical Data

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The historical data trend for Tango Therapeutics's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Tango Therapeutics ROE % Adjusted to Book Value Chart

Tango Therapeutics Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
Get a 7-Day Free Trial -10.93 -14.22 -10.12 -34.48 -10.70

Tango Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -97.87 -24.47 7.35 -17.60 -6.41

TNGX vs LEGN, CAI, EWTX: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Tango Therapeutics's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Tango Therapeutics ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Tango Therapeutics's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Tango Therapeutics's ROE % Adjusted to Book Value falls into.


TNGX
54GF Score
Tango Therapeutics Inc TNGX
ROE % Adjusted to Book Value is just one metric. See GF Score™, valuation, warning signs, and more.
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Tango Therapeutics ROE % Adjusted to Book Value Calculation

Tango Therapeutics's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-37.23% / 3.48
=-10.70%

Tango Therapeutics's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-49.36% / 7.70
=-6.41%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of -6.41% mean?
Tango Therapeutics (TNGX) has a ROE % Adjusted to Book Value of -6.41% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Tango Therapeutics and its competitors.
Is Tango Therapeutics' ROE % Adjusted to Book Value too high?
Tango Therapeutics' current ROE % Adjusted to Book Value is -6.41%. Overall, Tango Therapeutics has a GF Score™ of 54/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Tango Therapeutics' ROE % Adjusted to Book Value compare to LEGN and CAI?
Tango Therapeutics' ROE % Adjusted to Book Value of -6.41% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Tango Therapeutics and its competitors. Tango Therapeutics's current ROE % Adjusted to Book Value is -6.41%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Tango Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Tango Therapeutics (TNGX) is currently considered Significantly Overvalued. The stock's GF Value™ is $9.92, compared to a current price of $27.67 — trading 178.9% above its estimated fair value. The current ROE % Adjusted to Book Value is -6.41%. Tango Therapeutics' overall GF Score™ is 54/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Tango Therapeutics (TNGX), the current ROE % Adjusted to Book Value is -6.41% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Tango Therapeutics (TNGX) Overvalued in 2026?

Based on GuruFocus' analysis, Tango Therapeutics stock appears to be overvalued. The current stock price of $27.67 is trading 178.9% above its estimated GF Value™ of $9.92. GuruFocus considers Tango Therapeutics to be Significantly Overvalued.

Key valuation signals for TNGX:

  • ROE % Adjusted to Book Value: -6.41%
  • GF Value™: $9.92 vs. price of $27.67 (178.9% above fair value)
  • GF Score™: 54/100 with 4 warning signs

No single metric tells the full story. See the TNGX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Tango Therapeutics Business Description

Address 201 Brookline Avenue, Suite 901, Boston, MA, USA, 02215
Tango Therapeutics Inc is a biotechnology company. It is dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. It is engaged in the business of discovering and developing precision oncology therapies. It is currently developing two MTA-cooperative PRMT5 inhibitors; TNG462 for non-CNS cancers, including pancreatic and lung cancer, and TNG456, a next-generation, brain-penetrant PRMT5 inhibitor, for CNS cancers, including GBM. Its pipeline products are PRMT5 and CoREST.
54GF Score

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ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$27.67
Price
$9.92
GF Value