TWi Biotechnology (ROCO:6610) ROE %: -120.33% (As of Dec. 2025)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

ROCO:6610 TWi Biotechnology Inc ROCO:6610
34 GF Score
Price NT$27.20
! 2 Warning Signs
View Full Analysis

What is TWi Biotechnology ROE %?

TWi Biotechnology ROCO:6610 +0.37% 34 ROE % is -120.33% as of Dec. 2025. GuruFocus rates ROCO:6610 with a GF Score™ of 34/100. The stock has 2 warning signs investors should review. Among 1,250 Biotechnology companies, TWi Biotechnology ranks worse than 62.72% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. TWi Biotechnology's annualized net income for the quarter that ended in Dec. 2025 was NT$-541.07 Mil. TWi Biotechnology's average Total Stockholders Equity over the quarter that ended in Dec. 2025 was NT$449.65 Mil. Therefore, TWi Biotechnology's annualized ROE % for the quarter that ended in Dec. 2025 was -120.33%.

The historical rank and industry rank for TWi Biotechnology's ROE % or its related term are showing as below:

ROCO:6610' s ROE % Range Over the Past 10 Years
Min: -85.2   Med: -30.89   Max: -5.34
Current: -62.82

During the past 13 years, TWi Biotechnology's highest ROE % was -5.34%. The lowest was -85.20%. And the median was -30.89%.

ROCO:6610's ROE % is ranked worse than
62.72% of 1250 companies
in the Biotechnology industry
Industry Median: -38.615 vs ROCO:6610: -62.82

TWi Biotechnology  (ROCO:6610) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-541.066/449.65
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(-541.066 / 0)*(0 / 558.578)*(558.578 / 449.65)
=Net Margin %*Asset Turnover*Equity Multiplier
=N/A %*0*1.2423
=ROA %*Equity Multiplier
=N/A %*1.2423
=-120.33 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-541.066/449.65
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (-541.066 / -541.066) * (-541.066 / -549.516) * (-549.516 / 0) * (0 / 558.578) * (558.578 / 449.65)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * 0.9846 * N/A % * 0 * 1.2423
=-120.33 %

Note: The net income data used here is two times the semi-annual (Dec. 2025) net income data. The Revenue data used here is two times the semi-annual (Dec. 2025) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


TWi Biotechnology ROE % Related Terms


TWi Biotechnology ROE % Historical Data

* Premium members only.

The historical data trend for TWi Biotechnology's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

TWi Biotechnology ROE % Chart

TWi Biotechnology Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -5.34 -31.43 -62.41 -85.20 -49.71

TWi Biotechnology Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -102.72 -66.03 -149.46 -32.31 -120.33

ROCO:6610 vs VRTX, REGN, ALNY: ROE % Comparison

For the Biotechnology subindustry, TWi Biotechnology's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


TWi Biotechnology ROE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, TWi Biotechnology's ROE % distribution charts can be found below:

* The bar in red indicates where TWi Biotechnology's ROE % falls into.


ROCO:6610
34GF Score
TWi Biotechnology Inc ROCO:6610
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

TWi Biotechnology ROE % Calculation

TWi Biotechnology's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=-357.518/( (807.956+630.438)/ 2 )
=-357.518/719.197
=-49.71 %

TWi Biotechnology's annualized ROE % for the quarter that ended in Dec. 2025 is calculated as

ROE %=Net Income (Q: Dec. 2025 )/( (Total Stockholders Equity (Q: Jun. 2025 )+Total Stockholders Equity (Q: Dec. 2025 ))/ count )
=-541.066/( (268.862+630.438)/ 2 )
=-541.066/449.65
=-120.33 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is two times the semi-annual (Dec. 2025) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of -120.33% mean?
TWi Biotechnology (ROCO:6610) has a ROE % of -120.33% as of Dec. 2025. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on TWi Biotechnology and its competitors. According to the industry distribution chart, TWi Biotechnology ranks #784 out of 1250 companies in the Biotechnology industry, placing it in the top 62.7%.
Is TWi Biotechnology's ROE % too high?
TWi Biotechnology's current ROE % is -120.33%. Based on the distribution chart, TWi Biotechnology ranks #784 out of 1250 companies in the Biotechnology industry, which is below the industry midpoint. Overall, TWi Biotechnology has a GF Score™ of 34/100, reflecting its overall financial health beyond just this single metric.
How does TWi Biotechnology's ROE % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, TWi Biotechnology ranks #784 out of 1250 companies for ROE %. This places TWi Biotechnology in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on TWi Biotechnology and its competitors. TWi Biotechnology's current ROE % is -120.33%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is TWi Biotechnology stock overvalued right now?
TWi Biotechnology (ROCO:6610) has a current ROE % of -120.33%. The current ROE % is -120.33%. TWi Biotechnology's overall GF Score™ is 34/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For TWi Biotechnology (ROCO:6610), the current ROE % is -120.33% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

TWi Biotechnology Business Description

Address Lane 221, Kang Chien Road, 8th Floor, Number 41, Neihu District, Taipei, TWN, 11494
TWi Biotechnology Inc is a clinical-stage biopharmaceutical company based in Taiwan. It is engaged in the development of new drugs for unmet medical needs, particularly in the diseases associated with innate immunity. The pipeline products of the company comprise AC-201, AC-203, and AC-701.
34GF Score

Get the complete analysis for ROCO:6610

ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

NT$27.20
Price