Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
ASEP Medical HoldingsSEPSF 19 ROE % is -49.84% as of Mar. 2026. GuruFocus rates SEPSF with a GF Score™ of 19/100. The stock has 4 warning signs investors should review. Among 1,251 Biotechnology companies, ASEP Medical Holdings ranks worse than 78.02% on this metric.
The historical rank and industry rank for ASEP Medical Holdings's ROE % or its related term are showing as below:
SEPSF'
s ROE % Range Over the Past 10 Years
Min: -135.33 Med: -58.59 Max: -12.05
Current: -115.23
During the past 5 years, ASEP Medical Holdings's highest ROE % was -12.05%. The lowest was -135.33%. And the median was -58.59%.
SEPSF's ROE % is ranked worse than 78.02% of 1251
companies
in the Biotechnology industry
Industry Median: -38.61
vs SEPSF: -115.23
ASEP Medical Holdings (OTCPK:SEPSF) ROE % Explanation
ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.
The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:
Note:
The net income data used here is four times the quarterly (Mar. 2026) net income data. The Revenue data used here is four times the quarterly (Mar. 2026) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Be Aware
Net Income is used.
Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, ASEP Medical Holdings's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
ASEP Medical Holdings ROE % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, ASEP Medical Holdings's ROE % distribution charts can be found below:
* The bar in red indicates where ASEP Medical Holdings's ROE % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
ROE % is displayed in the 30-year financial page.
ASEP Medical Holdings (SEPSF) has a ROE % of -49.84% as of Mar. 2026. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on ASEP Medical Holdings and its competitors. According to the industry distribution chart, ASEP Medical Holdings ranks #976 out of 1251 companies in the Biotechnology industry, placing it in the top 78%.
Is ASEP Medical Holdings' ROE % too high?
ASEP Medical Holdings' current ROE % is -49.84%. Based on the distribution chart, ASEP Medical Holdings ranks #976 out of 1251 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, ASEP Medical Holdings has a GF Score™ of 19/100, reflecting its overall financial health beyond just this single metric.
How does ASEP Medical Holdings' ROE % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, ASEP Medical Holdings ranks #976 out of 1251 companies for ROE %. This places ASEP Medical Holdings in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on ASEP Medical Holdings and its competitors. ASEP Medical Holdings's current ROE % is -49.84%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ASEP Medical Holdings stock overvalued right now?
ASEP Medical Holdings (SEPSF) has a current ROE % of -49.84%. The current ROE % is -49.84%. ASEP Medical Holdings' overall GF Score™ is 19/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For ASEP Medical Holdings (SEPSF), the current ROE % is -49.84% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
ASEP Medical Holdings Inc is in the business of acquiring research and development assets, technologies and/or businesses in the area of life sciences and medical diagnostics. Diagnostic and therapeutic solutions represent tremendous clinical and commercial potential, through rapid diagnostics and uniquely effective treatments. Its Diagnostic has developed a novel diagnostic assay for the early and rapid risk assessment of sepsis. Therapeutic offering: Patented peptide technology targets infection-causing biofilms and reduces inflammation.
19GF Score
Get the complete analysis for SEPSF
ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
SEPSF has been successfully added to your 
