Seres Therapeutics (STU:1S90) ROE %: 60.13% (As of Jun. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

STU:1S90 Seres Therapeutics Inc STU:1S90
25 GF Score
Price €4.05
! 5 Warning Signs
View Full Analysis

What is Seres Therapeutics ROE %?

Seres Therapeutics STU:1S90 -4.71% 25 ROE % is 60.13% as of Jun. 2026. GuruFocus rates STU:1S90 with a GF Score™ of 25/100. The stock has 5 warning signs investors should review. Among 1,250 Biotechnology companies, Seres Therapeutics ranks worse than 63.28% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. Seres Therapeutics's annualized net income for the quarter that ended in Jun. 2026 was €15.90 Mil. Seres Therapeutics's average Total Stockholders Equity over the quarter that ended in Jun. 2026 was €26.45 Mil. Therefore, Seres Therapeutics's annualized ROE % for the quarter that ended in Jun. 2026 was 60.13%.

The historical rank and industry rank for Seres Therapeutics's ROE % or its related term are showing as below:

STU:1S90' s ROE % Range Over the Past 10 Years
Min: -1563.81   Med: -92.46   Max: 19.64
Current: -61.75

During the past 13 years, Seres Therapeutics's highest ROE % was 19.64%. The lowest was -1,563.81%. And the median was -92.46%.

STU:1S90's ROE % is ranked worse than
63.28% of 1250 companies
in the Biotechnology industry
Industry Median: -38.84 vs STU:1S90: -61.75

Seres Therapeutics  (STU:1S90) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Jun. 2026 )
=Net Income/Total Stockholders Equity
=15.904/26.449
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(15.904 / 2.556)*(2.556 / 94.959)*(94.959 / 26.449)
=Net Margin %*Asset Turnover*Equity Multiplier
=622.22 %*0.0269*3.5903
=ROA %*Equity Multiplier
=16.74 %*3.5903
=60.13 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Jun. 2026 )
=Net Income/Total Stockholders Equity
=15.904/26.449
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (15.904 / 15.904) * (15.904 / -53.696) * (-53.696 / 2.556) * (2.556 / 94.959) * (94.959 / 26.449)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * -0.2962 * -2100.78 % * 0.0269 * 3.5903
=60.13 %

Note: The net income data used here is four times the quarterly (Jun. 2026) net income data. The Revenue data used here is four times the quarterly (Jun. 2026) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


Seres Therapeutics ROE % Related Terms


Seres Therapeutics ROE % Historical Data

* Premium members only.

The historical data trend for Seres Therapeutics's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Seres Therapeutics ROE % Chart

Seres Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -44.64 -373.17 0.00 Negative Equity 19.10

Seres Therapeutics Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -183.01 84.99 -139.71 -227.08 60.13

STU:1S90 vs IBO, TIL, ATYR: ROE % Comparison

For the Biotechnology subindustry, Seres Therapeutics's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Seres Therapeutics ROE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Seres Therapeutics's ROE % distribution charts can be found below:

* The bar in red indicates where Seres Therapeutics's ROE % falls into.


STU:1S90
25GF Score
Seres Therapeutics Inc STU:1S90
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Seres Therapeutics ROE % Calculation

Seres Therapeutics's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=4.864/( (13.164+37.762)/ 2 )
=4.864/25.463
=19.10 %

Seres Therapeutics's annualized ROE % for the quarter that ended in Jun. 2026 is calculated as

ROE %=Net Income (Q: Jun. 2026 )/( (Total Stockholders Equity (Q: Mar. 2026 )+Total Stockholders Equity (Q: Jun. 2026 ))/ count )
=15.904/( (22.922+29.976)/ 2 )
=15.904/26.449
=60.13 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Jun. 2026) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of 60.13% mean?
Seres Therapeutics (STU:1S90) has a ROE % of 60.13% as of Jun. 2026. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Seres Therapeutics and its competitors. According to the industry distribution chart, Seres Therapeutics ranks #791 out of 1250 companies in the Biotechnology industry, placing it in the top 63.3%.
Is Seres Therapeutics' ROE % too high?
Seres Therapeutics' current ROE % is 60.13%. Based on the distribution chart, Seres Therapeutics ranks #791 out of 1250 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Seres Therapeutics has a GF Score™ of 25/100, reflecting its overall financial health beyond just this single metric.
How does Seres Therapeutics' ROE % compare to IBO and TIL?
According to the Biotechnology industry distribution chart, Seres Therapeutics ranks #791 out of 1250 companies for ROE %. This places Seres Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Seres Therapeutics and its competitors. Seres Therapeutics's current ROE % is 60.13%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Seres Therapeutics stock overvalued right now?
Seres Therapeutics (STU:1S90) has a current ROE % of 60.13%. The current ROE % is 60.13%. Seres Therapeutics' overall GF Score™ is 25/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For Seres Therapeutics (STU:1S90), the current ROE % is 60.13% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Seres Therapeutics Business Description

Other Exchanges MCRB:USA
Address 101 Cambridgepark Drive, Cambridge, MA, USA, 02140
Seres Therapeutics Inc is a clinical-stage biotechnology company focused on the development of live biotherapeutic candidates. Its pipeline includes candidates such as SER-155 and SER-603, aimed at preventing and treating bacterial infections, antimicrobial resistance, and gastrointestinal immune diseases. The company operates as a single reportable segment, mainly developing microbiome-based therapies targeting bacterial infections, antimicrobial resistance, and gastrointestinal immune diseases.
25GF Score

Get the complete analysis for STU:1S90

ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€4.05
Price