ODTX (Odyssey Therapeutics) ROIC %: -218.84% (As of Mar. 2026)


ODTX Odyssey Therapeutics Inc ODTX
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What is Odyssey Therapeutics ROIC %?

Odyssey Therapeutics ODTX +2.01% 9 ROIC % is -218.84% as of Mar. 2026. GuruFocus rates ODTX with a GF Score™ of 9/100. The stock has 2 warning signs investors should review.

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. Odyssey Therapeutics's annualized return on invested capital (ROIC %) for the quarter that ended in Mar. 2026 was -218.84%.

As of today (2026-06-30), Odyssey Therapeutics's WACC % is 10.08%. Odyssey Therapeutics's ROIC % is -54.71% (calculated using TTM income statement data). Odyssey Therapeutics earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Odyssey Therapeutics  (NAS:ODTX) ROIC % Explanation

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. The reason book values of debt and equity are used is because the book values are the capital the company received when issuing the debt or receiving the equity investments.

There are four key components to this definition. The first is the use of operating income or EBIT rather than net income in the numerator. The second is the tax adjustment to this operating income or EBIT, computed as a hypothetical tax based on an effective or marginal tax rate. The third is the use of book values for invested capital, rather than market values. The final is the timing difference; the capital invested is from the end of the prior year whereas the operating income or EBIT is the current year's number.

Why is ROIC % important?

Because it costs money to raise capital. A firm that generates higher returns on investment than it costs the company to raise the capital needed for that investment is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases, whereas a firm that earns returns that do not match up to its cost of capital will destroy value as it grows.

As of today, Odyssey Therapeutics's WACC % is 10.08%. Odyssey Therapeutics's ROIC % is -54.71% (calculated using TTM income statement data). Odyssey Therapeutics earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Be Aware

Like ROE % and ROA %, ROIC % is calculated with only 12 months of data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.


Odyssey Therapeutics ROIC % Related Terms


Odyssey Therapeutics ROIC % Historical Data

* Premium members only.

The historical data trend for Odyssey Therapeutics's ROIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Odyssey Therapeutics ROIC % Chart

Odyssey Therapeutics Annual Data
Trend Dec22 Dec23 Dec24 Dec25
ROIC %
-154.93 -144.28 -145.47 -186.58

Odyssey Therapeutics Quarterly Data
Dec22 Dec23 Sep24 Dec24 Mar25 Dec25 Mar26
ROIC % Get a 7-Day Free Trial 0.00 -191.18 -223.49 0.00 -218.84

ODTX vs VOR, PHAT, GERN: ROIC % Comparison

For the Biotechnology subindustry, Odyssey Therapeutics's ROIC %, along with its competitors' market caps and ROIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Odyssey Therapeutics ROIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Odyssey Therapeutics's ROIC % distribution charts can be found below:

* The bar in red indicates where Odyssey Therapeutics's ROIC % falls into.


ODTX
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Odyssey Therapeutics Inc ODTX
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Odyssey Therapeutics ROIC % Calculation

Odyssey Therapeutics's annualized Return on Invested Capital (ROIC %) for the fiscal year that ended in Dec. 2025 is calculated as:

ROIC % (A: Dec. 2025 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (A: Dec. 2024 ) + Invested Capital (A: Dec. 2025 ))/ count )
=-161.156 * ( 1 - 0.62% )/( (80.196 + 91.484)/ 2 )
=-160.1568328/85.84
=-186.58 %

where

Invested Capital(A: Dec. 2025 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=269.788 - 14.123 - ( 181.358 - max(0, 26.475 - 190.656+181.358))
=91.484

Odyssey Therapeutics's annualized Return on Invested Capital (ROIC %) for the quarter that ended in Mar. 2026 is calculated as:

ROIC % (Q: Mar. 2026 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (Q: Dec. 2025 ) + Invested Capital (Q: Mar. 2026 ))/ count )
=-158.684 * ( 1 - 0% )/( (91.484 + 53.542)/ 2 )
=-158.684/72.513
=-218.84 %

where

Invested Capital(Q: Dec. 2025 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=269.788 - 14.123 - ( 181.358 - max(0, 26.475 - 190.656+181.358))
=91.484

Note: The Operating Income data used here is four times the quarterly (Mar. 2026) data. The tax rate is limited to between 0% and 100%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about ROIC % →
What does a ROIC % of -218.84% mean?
Odyssey Therapeutics (ODTX) has a ROIC % of -218.84% as of Mar. 2026. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Odyssey Therapeutics and its competitors.
Is Odyssey Therapeutics' ROIC % too high?
Odyssey Therapeutics' current ROIC % is -218.84%. Overall, Odyssey Therapeutics has a GF Score™ of 9/100, reflecting its overall financial health beyond just this single metric.
How does Odyssey Therapeutics' ROIC % compare to VOR and PHAT?
Odyssey Therapeutics' ROIC % of -218.84% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROIC % for a Biotechnology company?
A good ROIC % depends on the Biotechnology industry context. However, ROIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROIC % mean?
A high ROIC % can signal that a stock is expensive relative to its fundamentals. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Odyssey Therapeutics and its competitors. Odyssey Therapeutics's current ROIC % is -218.84%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Odyssey Therapeutics stock overvalued right now?
Odyssey Therapeutics (ODTX) has a current ROIC % of -218.84%. The current ROIC % is -218.84%. Odyssey Therapeutics' overall GF Score™ is 9/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROIC % calculated?
ROIC % is calculated from a company's financial statements. For Odyssey Therapeutics (ODTX), the current ROIC % is -218.84% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Odyssey Therapeutics Business Description

Address 51 Sleeper Street, Boston, MA, USA, 02210
Odyssey Therapeutics Inc is a clinical-stage biopharmaceutical company seeking to transform the standard of care for patients suffering from autoimmune and inflammatory diseases. The Company is developing medicines that are designed to precisely target disease pathology with an initial emphasis on the innate immune system. Its programs include OD-07656, a small molecule scaffolding inhibitor of receptor-interacting protein kinase 2, or RIPK2, a small molecule scaffolding inhibitor of interleukin-1 receptor-associated kinase 4, or IRAK4, and OD-00910, an agonistic protein therapeutic targeting tumor necrosis factor receptor 2, or TNFR2, built from camelid heavy chain variable regions, or VHH, domains.
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