PBLS (Parabilis Medicines) ROIC %: -194.92% (As of Dec. 2025)

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PBLS Parabilis Medicines Inc PBLS
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What is Parabilis Medicines ROIC %?

Parabilis Medicines PBLS -4.66% 10 ROIC % is -194.92% as of Dec. 2025. GuruFocus rates PBLS with a GF Score™ of 10/100. The stock has 1 warning sign investors should review.

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. Parabilis Medicines's annualized return on invested capital (ROIC %) for the quarter that ended in Dec. 2025 was -194.92%.

As of today (2026-07-25), Parabilis Medicines's WACC % is 10.58%. Parabilis Medicines's ROIC % is -194.92% (calculated using TTM income statement data). Parabilis Medicines earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Parabilis Medicines  (NAS:PBLS) ROIC % Explanation

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. The reason book values of debt and equity are used is because the book values are the capital the company received when issuing the debt or receiving the equity investments.

There are four key components to this definition. The first is the use of operating income or EBIT rather than net income in the numerator. The second is the tax adjustment to this operating income or EBIT, computed as a hypothetical tax based on an effective or marginal tax rate. The third is the use of book values for invested capital, rather than market values. The final is the timing difference; the capital invested is from the end of the prior year whereas the operating income or EBIT is the current year's number.

Why is ROIC % important?

Because it costs money to raise capital. A firm that generates higher returns on investment than it costs the company to raise the capital needed for that investment is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases, whereas a firm that earns returns that do not match up to its cost of capital will destroy value as it grows.

As of today, Parabilis Medicines's WACC % is 10.58%. Parabilis Medicines's ROIC % is -194.92% (calculated using TTM income statement data). Parabilis Medicines earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Be Aware

Like ROE % and ROA %, ROIC % is calculated with only 12 months of data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.


Parabilis Medicines ROIC % Related Terms


Parabilis Medicines ROIC % Historical Data

* Premium members only.

The historical data trend for Parabilis Medicines's ROIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Parabilis Medicines ROIC % Chart

Parabilis Medicines Annual Data
Trend Dec24 Dec25
ROIC %
-171.85 -194.92

Parabilis Medicines Semi-Annual Data
Dec24 Dec25
ROIC % -171.85 -194.92

PBLS vs IDYA, ELVN, BEAM: ROIC % Comparison

For the Biotechnology subindustry, Parabilis Medicines's ROIC %, along with its competitors' market caps and ROIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Parabilis Medicines ROIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Parabilis Medicines's ROIC % distribution charts can be found below:

* The bar in red indicates where Parabilis Medicines's ROIC % falls into.


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Parabilis Medicines ROIC % Calculation

Parabilis Medicines's annualized Return on Invested Capital (ROIC %) for the fiscal year that ended in Dec. 2025 is calculated as:

ROIC % (A: Dec. 2025 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (A: Dec. 2024 ) + Invested Capital (A: Dec. 2025 ))/ count )
=-152.079 * ( 1 - 0% )/( (73.392 + 82.647)/ 2 )
=-152.079/78.0195
=-194.92 %

where

Parabilis Medicines's annualized Return on Invested Capital (ROIC %) for the quarter that ended in Dec. 2025 is calculated as:

ROIC % (Q: Dec. 2025 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (Q: Dec. 2024 ) + Invested Capital (Q: Dec. 2025 ))/ count )
=-152.079 * ( 1 - 0% )/( (73.392 + 82.647)/ 2 )
=-152.079/78.0195
=-194.92 %

where

Note: The Operating Income data used here is one times the annual (Dec. 2025) data. The tax rate is limited to between 0% and 100%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about ROIC % →
What does a ROIC % of -194.92% mean?
Parabilis Medicines (PBLS) has a ROIC % of -194.92% as of Dec. 2025. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Parabilis Medicines and its competitors.
Is Parabilis Medicines' ROIC % too high?
Parabilis Medicines' current ROIC % is -194.92%. Overall, Parabilis Medicines has a GF Score™ of 10/100, reflecting its overall financial health beyond just this single metric.
How does Parabilis Medicines' ROIC % compare to IDYA and ELVN?
Parabilis Medicines' ROIC % of -194.92% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROIC % for a Biotechnology company?
A good ROIC % depends on the Biotechnology industry context. However, ROIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROIC % mean?
A high ROIC % can signal that a stock is expensive relative to its fundamentals. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Parabilis Medicines and its competitors. Parabilis Medicines's current ROIC % is -194.92%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Parabilis Medicines stock overvalued right now?
Parabilis Medicines (PBLS) has a current ROIC % of -194.92%. The current ROIC % is -194.92%. Parabilis Medicines' overall GF Score™ is 10/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROIC % calculated?
ROIC % is calculated from a company's financial statements. For Parabilis Medicines (PBLS), the current ROIC % is -194.92% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Parabilis Medicines Business Description

Address 30 Acorn Park Drive, Cambridge Discovery Park, Cambridge, MA, USA, 02140
Parabilis Medicines Inc s a clinical-stage biopharmaceutical company. It is focused on the development of medicines targeting protein interactions associated with human diseases. It uses a proprietary platform to develop stabilized helical peptide therapeutics, referred to as Helicons, designed to bind and modulate specific proteins. Its flagship product candidate, zolucatetide, targets the interaction between ?-catenin and the T-cell factor (TCF) family of transcription factors within the Wnt/?-catenin signaling pathway, which is associated with cell proliferation and differentiation in multiple cancer types.
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