Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Mustang BioMBIO +11.79%32 3-Year ROIIC % is -418.29 as of Dec. 2025. GuruFocus rates MBIO with a GF Score™ of 32/100. The stock has 2 warning signs investors should review. Among 1,319 Biotechnology companies, Mustang Bio ranks worse than 87.26% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Mustang Bio's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -418.29%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Mustang Bio's 3-Year ROIIC % or its related term are showing as below:
MBIO's 3-Year ROIIC % is ranked worse than 87.26% of 1319
companies
in the Biotechnology industry
Industry Median: -4.85
vs MBIO: -418.29
Mustang Bio (NAS:MBIO) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Mustang Bio 3-Year ROIIC % Related Terms
Mustang Bio 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Mustang Bio's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
MBIO vs FBLG, ERNA, REVB: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Mustang Bio's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Mustang Bio 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Mustang Bio's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Mustang Bio's 3-Year ROIIC % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Mustang Bio (MBIO) has a 3-Year ROIIC % of -418.29 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Mustang Bio and its competitors. According to the industry distribution chart, Mustang Bio ranks #1151 out of 1319 companies in the Biotechnology industry, placing it in the top 87.3%.
Is Mustang Bio's 3-Year ROIIC % too high?
Mustang Bio's current 3-Year ROIIC % is -418.29. Based on the distribution chart, Mustang Bio ranks #1151 out of 1319 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Mustang Bio has a GF Score™ of 32/100, reflecting its overall financial health beyond just this single metric.
How does Mustang Bio's 3-Year ROIIC % compare to FBLG and ERNA?
According to the Biotechnology industry distribution chart, Mustang Bio ranks #1151 out of 1319 companies for 3-Year ROIIC %. This places Mustang Bio in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Mustang Bio and its competitors. Mustang Bio's current 3-Year ROIIC % is -418.29. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Mustang Bio stock overvalued right now?
Mustang Bio (MBIO) has a current 3-Year ROIIC % of -418.29. The current 3-Year ROIIC % is -418.29. Mustang Bio's overall GF Score™ is 32/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Mustang Bio (MBIO), the current 3-Year ROIIC % is -418.29 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Mustang Bio Inc is a clinical-stage biopharmaceutical company focused on translating today's medical breakthroughs into potential cures for difficult-to-treat cancers. It acquires rights to these technologies by licensing or otherwise acquiring an ownership interest in the technologies, funding their research and development, and eventually either out-licensing or bringing the technologies to market. Its pipeline is currently focused on the core areas of gene therapies for rare genetic disorders, chimeric antigen receptor (CAR) engineered T cell (CAR T) therapies for hematologic malignancies, and CAR T therapies for solid tumors.
32GF Score
Get the complete analysis for MBIO
3-Year ROIIC % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
MBIO has been successfully added to your 
