NeurogeneNGNE -7.87%12 3-Year ROIIC % is 1,800.42 as of Dec. 2025, which is 23% above its 10-year median of 1,464.84. GuruFocus rates NGNE with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,320 Biotechnology companies, Neurogene ranks better than 95.98% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Neurogene's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 1,800.42%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Neurogene's 3-Year ROIIC % or its related term are showing as below:
NGNE's 3-Year ROIIC % is ranked better than 95.98% of 1320
companies
in the Biotechnology industry
Industry Median: -4.42
vs NGNE: 1800.42
Neurogene (NAS:NGNE) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Neurogene 3-Year ROIIC % Related Terms
Neurogene 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Neurogene's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
NGNE vs STRO, OCGN, CBIO: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Neurogene's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Neurogene 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Neurogene's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Neurogene's 3-Year ROIIC % falls into.
Neurogene's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -103.328 (Dec. 2025) - -56.517 (Dec. 2022) )
/
( 26.172 (Dec. 2025) - 28.772 (Dec. 2022) )
=
-46.811
/
-2.6
=
1,800.42%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Neurogene (NGNE) has a 3-Year ROIIC % of 1,800.42 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Neurogene and its competitors. This is 23% above median its historical median of 1,464.84. Over the past decade, Neurogene's 3-Year ROIIC % has ranged from 1,129.26 to 1,800.42. According to the industry distribution chart, Neurogene ranks #53 out of 1320 companies in the Biotechnology industry, placing it in the top 4%.
Is Neurogene's 3-Year ROIIC % too high?
Neurogene's current 3-Year ROIIC % of 1,800.42 is 23% above median its 10-year median of 1,464.84. Over the past 10 years, this metric has ranged from a low of 1,129.26 to a high of 1,800.42. Based on the distribution chart, Neurogene ranks #53 out of 1320 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Neurogene has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Neurogene's 3-Year ROIIC % compare to STRO and OCGN?
According to the Biotechnology industry distribution chart, Neurogene ranks #53 out of 1320 companies for 3-Year ROIIC %. This places Neurogene in the top 4% of its industry — outperforming the majority of peers. Historically, Neurogene's own 3-Year ROIIC % has ranged from 1,129.26 to 1,800.42 over the past decade. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Neurogene and its competitors. Neurogene's current 3-Year ROIIC % is 1,800.42, which is 23% above median its own 10-year median of 1,464.84. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Neurogene stock overvalued right now?
Neurogene (NGNE) has a current 3-Year ROIIC % of 1,800.42. The current 3-Year ROIIC % is 1,800.42, which is 23% above median its 10-year median of 1,464.84. Neurogene's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Neurogene (NGNE), the current 3-Year ROIIC % is 1,800.42 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Neurogene Inc is a clinical-stage biotechnology company committed to overcoming the limitations of neurological diseases into treatable conditions, by harnessing its proprietary transgene regulation technology, EXACT(Expression Attenuation via Construct Tuning). It is building a differentiated product portfolio of genetic medicines for rare neurological diseases with high unmet needs. The drug candidates in the company's product pipeline include NGN-401, which is in development for the treatment of Rett syndrome, using its EXACT platform, and NGN-101, a non-EXACT, conventional gene therapy development candidate for the treatment of CLN5 Batten disease, designed to deliver the CLN5 gene and packaged in an AAV9 capsid.
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