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5-Year Return on Invested Incremental Capital (5-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 5-year.
UroGen Pharma's 5-Year ROIIC % for the quarter that ended in Dec. 2025 was 5.44%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for UroGen Pharma's 5-Year ROIIC % or its related term are showing as below:
LTS:0XOD's 5-Year ROIIC % is ranked better than 62.94% of 1171
companies
in the Biotechnology industry
Industry Median: -11.04
vs LTS:0XOD: 5.44
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
UroGen Pharma 5-Year ROIIC % Related Terms
UroGen Pharma 5-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for UroGen Pharma's 5-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
LTS:0XOD vs PVLA, AUPH, RAPP: 5-Year ROIIC % Comparison
For the Biotechnology subindustry, UroGen Pharma's 5-Year ROIIC %, along with its competitors' market caps and 5-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
UroGen Pharma 5-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, UroGen Pharma's 5-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where UroGen Pharma's 5-Year ROIIC % falls into.
UroGen Pharma's 5-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
5-Year ROIIC %
=
5-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
5-Year Incremental Invested Capital**
=
( -124.863 (Dec. 2025) - -126.739 (Dec. 2020) )
/
( 52.282 (Dec. 2025) - 17.799 (Dec. 2020) )
=
1.876
/
34.483
=
5.44%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 5-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
UroGen Pharma (LTS:0XOD) has a 5-Year ROIIC % of 5.44 as of Dec. 2025. 5-Year ROIIC % measures the change in earnings as a percentage of change in investment over 5-year. View historical data on UroGen Pharma and its competitors. According to the industry distribution chart, UroGen Pharma ranks #434 out of 1171 companies in the Biotechnology industry, placing it in the top 37.1%.
Is UroGen Pharma's 5-Year ROIIC % too high?
UroGen Pharma's current 5-Year ROIIC % is 5.44. Based on the distribution chart, UroGen Pharma ranks #434 out of 1171 companies in the Biotechnology industry, which is above the industry midpoint. Overall, UroGen Pharma has a GF Score™ of 52/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does UroGen Pharma's 5-Year ROIIC % compare to PVLA and AUPH?
According to the Biotechnology industry distribution chart, UroGen Pharma ranks #434 out of 1171 companies for 5-Year ROIIC %. This puts UroGen Pharma in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 5-Year ROIIC % for a Biotechnology company?
A good 5-Year ROIIC % depends on the Biotechnology industry context. However, 5-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 5-Year ROIIC % mean?
A high 5-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 5-Year ROIIC % measures the change in earnings as a percentage of change in investment over 5-year. View historical data on UroGen Pharma and its competitors. UroGen Pharma's current 5-Year ROIIC % is 5.44. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is UroGen Pharma stock overvalued right now?
Based on GuruFocus' analysis, UroGen Pharma (LTS:0XOD) is currently considered Significantly Overvalued. The stock's GF Value™ is $22.63, compared to a current price of $38.60 — trading 70.6% above its estimated fair value. The current 5-Year ROIIC % is 5.44. UroGen Pharma's overall GF Score™ is 52/100 with 10 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 5-Year ROIIC % calculated?
5-Year ROIIC % is calculated from a company's financial statements. For UroGen Pharma (LTS:0XOD), the current 5-Year ROIIC % is 5.44 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is UroGen Pharma (LTS:0XOD) Overvalued in 2026?
Based on GuruFocus' analysis, UroGen Pharma stock appears to be overvalued.
The current stock price of $38.60 is trading 70.6% above its estimated GF Value™ of $22.63.
GuruFocus considers UroGen Pharma to be Significantly Overvalued.
Key valuation signals for LTS:0XOD:
5-Year ROIIC %: 5.44
GF Value™: $22.63 vs. price of $38.60 (70.6% above fair value)
No single metric tells the full story. See the LTS:0XOD stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
UroGen Pharma Ltd is a clinical-stage biotechnology firm specializing in solutions for urothelial and specialty cancers. The company has developed RTGel reverse-thermal hydrogel, a proprietary technology enhancing the therapeutic profiles of existing drugs by enabling sustained release. The company's flagship product, Jelmyto (mitomycin) for pyelocalyceal solution, along with Zusduri (mitomycin) for intravesical solution, targets non-surgical tumor ablation in forms of non-muscle invasive urothelial cancer. The revenue source for the company comes from sales of the Company's approved products, Jelmyto and Zusduri, principally conducted in the United States.
52GF Score
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