MDGL (Madrigal Pharmaceuticals) Shiller PE Ratio: (As of Sep. 01, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

MDGL Madrigal Pharmaceuticals Inc MDGL
31 GF Score
Price $540.03
! 4 Warning Signs
View Full Analysis

What is Madrigal Pharmaceuticals Shiller PE Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


Madrigal Pharmaceuticals  (NAS:MDGL) Shiller PE Ratio Explanation

Compared with the regular PE Ratio, which works poorly for cyclical businesses, the Shiller PE Ratio smoothed out the fluctuations of profit margins during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Shiller PE Ratio should give similar results to regular PE Ratio.

Compared with the PS Ratio, the Shiller PE Ratio makes the comparison between different industries more meaningful.


Be Aware

Shiller PE Ratio assumes that over the long term, businesses and profitability revert to their means. If a company's business model does not work in the future compared with the past, Shiller PE Ratio and PS Ratio will give false valuations.


Madrigal Pharmaceuticals Shiller PE Ratio Related Terms


Madrigal Pharmaceuticals Shiller PE Ratio Historical Data

* Premium members only.

The historical data trend for Madrigal Pharmaceuticals's Shiller PE Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Madrigal Pharmaceuticals Shiller PE Ratio Chart

Madrigal Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Shiller PE Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

Madrigal Pharmaceuticals Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Shiller PE Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

MDGL vs CORT, BMRN, ARWR: Shiller PE Ratio Comparison

For the Biotechnology subindustry, Madrigal Pharmaceuticals's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Madrigal Pharmaceuticals Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Madrigal Pharmaceuticals's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Madrigal Pharmaceuticals's Shiller PE Ratio falls into.


MDGL
31GF Score
Madrigal Pharmaceuticals Inc MDGL
Shiller PE Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Madrigal Pharmaceuticals Shiller PE Ratio Calculation

For Shiller PE Ratio, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller PE Ratio is also called PE10.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

Madrigal Pharmaceuticals's E10 for the quarter that ended in Jun. 2026 is calculated as:

For example, Madrigal Pharmaceuticals's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS=Earnings per Share (Diluted)/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=-1.99/333.9520*333.9520
=-1.990

Current CPI (Jun. 2026) = 333.9520.

Madrigal Pharmaceuticals Quarterly Data

Earnings per Share (Diluted) CPI Adj_EPS
201609 -1.590 241.428 -2.199
201612 -0.670 241.432 -0.927
201703 -0.500 243.801 -0.685
201706 -0.690 244.955 -0.941
201709 -0.680 246.819 -0.920
201712 -0.670 246.524 -0.908
201803 -0.450 249.554 -0.602
201806 -0.450 251.989 -0.596
201809 -0.560 252.439 -0.741
201812 -0.750 251.233 -0.997
201903 -0.980 254.202 -1.287
201906 -1.280 256.143 -1.669
201909 -1.390 256.759 -1.808
201912 -1.800 256.974 -2.339
202003 -2.340 258.115 -3.028
202006 -3.180 257.797 -4.119
202009 -3.750 260.280 -4.811
202012 -3.820 260.474 -4.898
202103 -3.320 264.877 -4.186
202106 -3.720 271.696 -4.572
202109 -3.790 274.310 -4.614
202112 -3.780 278.802 -4.528
202203 -3.360 287.504 -3.903
202206 -4.140 296.311 -4.666
202209 -4.750 296.808 -5.344
202212 -4.980 296.797 -5.603
202303 -4.230 301.836 -4.680
202306 -4.690 305.109 -5.133
202309 -5.340 307.789 -5.794
202312 -5.720 306.746 -6.227
202403 -7.380 312.332 -7.891
202406 -7.100 314.175 -7.547
202409 -4.920 315.301 -5.211
202412 -2.710 315.605 -2.868
202503 -2.610 319.799 -2.726
202506 -1.500 322.561 -1.553
202509 -5.080 324.800 -5.223
202512 -2.570 324.054 -2.648
202603 -3.250 330.213 -3.287
202606 -1.990 333.952 -1.990

Add all the adjusted EPS together and divide 10 will get our E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.


Madrigal Pharmaceuticals Business Description

Address 200 Barr Harbor Drive, Suite 200, Four Tower Bridge, West Conshohocken, PA, USA, 19428
Madrigal Pharmaceuticals Inc is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease with high unmet medical need that can lead to cirrhosis, liver failure, liver cancer, need for liver transplantation and premature mortality. Its medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed thyroid hormone receptor beta agonist designed to target key underlying causes of MASH.
31GF Score

Get the complete analysis for MDGL

Shiller PE Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$540.03
Price