OPKO Health (MEX:OPK) Cyclically Adjusted Book per Share: MXN57.66 (As of Mar. 2026)


MEX:OPK OPKO Health Inc MEX:OPK
53 GF Score
Price MXN26.20
GF Value MXN19.16
Valuation Significantly Overvalued
! 4 Warning Signs
View Full Analysis

What is OPKO Health Cyclically Adjusted Book per Share?

OPKO Health MEX:OPK 53 Cyclically Adjusted Book per Share is MXN57.66 as of Mar. 2026. GuruFocus rates MEX:OPK with a GF Score™ of 53/100 and a GF Value™ of MXN19.16 (Significantly Overvalued). The stock has 4 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

OPKO Health's adjusted book value per share for the three months ended in Mar. 2026 was MXN28.768. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is MXN57.66 for the trailing ten years ended in Mar. 2026.

During the past 12 months, OPKO Health's average Cyclically Adjusted Book Growth Rate was -4.90% per year. During the past 3 years, the average Cyclically Adjusted Book Growth Rate was 0.10% per year. During the past 5 years, the average Cyclically Adjusted Book Growth Rate was 5.20% per year. During the past 10 years, the average Cyclically Adjusted Book Growth Rate was 14.00% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted Book Growth Rate of OPKO Health was 36.20% per year. The lowest was -23.60% per year. And the median was 8.00% per year.

As of today (2026-07-13), OPKO Health's current stock price is MXN26.20. OPKO Health's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 was MXN57.66. OPKO Health's Cyclically Adjusted PB Ratio of today is 0.45.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of OPKO Health was 11.32. The lowest was 0.27. And the median was 1.01.


OPKO Health  (MEX:OPK) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

OPKO Health's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=26.20/57.66
=0.45

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of OPKO Health was 11.32. The lowest was 0.27. And the median was 1.01.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


OPKO Health Cyclically Adjusted Book per Share Related Terms


OPKO Health Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for OPKO Health's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health Cyclically Adjusted Book per Share Chart

OPKO Health Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 60.76 67.16 54.35 72.56 60.84

OPKO Health Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 67.19 62.80 52.42 60.84 57.66

MEX:OPK vs PSNL, CDNA, CSTL: Cyclically Adjusted Book per Share Comparison

For the Diagnostics & Research subindustry, OPKO Health's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OPKO Health Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where OPKO Health's Cyclically Adjusted PB Ratio falls into.


MEX:OPK
53GF Score
OPKO Health Inc MEX:OPK
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

OPKO Health Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, OPKO Health's adjusted Book Value per Share data for the three months ended in Mar. 2026 was:

Adj_Book= Book Value per Share /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=28.768/330.2130*330.2130
=28.768

Current CPI (Mar. 2026) = 330.2130.

OPKO Health Quarterly Data

Book Value per Share CPI Adj_Book
201606 68.058 241.018 93.245
201609 73.025 241.428 99.880
201612 77.290 241.432 105.712
201703 70.968 243.801 96.122
201706 68.078 244.955 91.773
201709 67.772 246.819 90.670
201712 64.718 246.524 86.688
201803 59.206 249.554 78.342
201806 63.571 251.989 83.305
201809 59.762 252.439 78.174
201812 59.986 251.233 78.844
201903 55.545 254.202 72.154
201906 53.325 256.143 68.745
201909 52.656 256.759 67.720
201912 45.466 256.974 58.424
202003 54.211 258.115 69.353
202006 54.734 257.797 70.109
202009 53.538 260.280 67.923
202012 49.584 260.474 62.860
202103 51.747 264.877 64.511
202106 50.925 271.696 61.893
202109 53.282 274.310 64.141
202112 50.730 278.802 60.085
202203 47.182 287.504 54.191
202206 44.795 296.311 49.920
202209 42.409 296.808 47.182
202212 39.404 296.797 43.840
202303 36.202 301.836 39.606
202306 34.050 305.109 36.852
202309 32.550 307.789 34.921
202312 30.495 306.746 32.828
202403 29.830 312.332 31.538
202406 36.655 314.175 38.526
202409 40.490 315.301 42.405
202412 42.405 315.605 44.368
202503 39.955 319.799 41.256
202506 31.316 322.561 32.059
202509 31.154 324.800 31.673
202512 30.077 324.054 30.649
202603 28.768 330.213 28.768

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of MXN57.66 mean?
OPKO Health (MEX:OPK) has a Cyclically Adjusted Book per Share of MXN57.66 as of Mar. 2026. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors.
Is OPKO Health's Cyclically Adjusted Book per Share too high?
OPKO Health's current Cyclically Adjusted Book per Share is MXN57.66. Overall, OPKO Health has a GF Score™ of 53/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OPKO Health's Cyclically Adjusted Book per Share compare to PSNL and CDNA?
OPKO Health's Cyclically Adjusted Book per Share of MXN57.66 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Medical Diagnostics & Research company?
A good Cyclically Adjusted Book per Share depends on the Medical Diagnostics & Research industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors. OPKO Health's current Cyclically Adjusted Book per Share is MXN57.66. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OPKO Health stock overvalued right now?
Based on GuruFocus' analysis, OPKO Health (MEX:OPK) is currently considered Significantly Overvalued. The stock's GF Value™ is MXN19.16, compared to a current price of MXN26.20 — trading 36.7% above its estimated fair value. The current Cyclically Adjusted Book per Share is MXN57.66. OPKO Health's overall GF Score™ is 53/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For OPKO Health (MEX:OPK), the current Cyclically Adjusted Book per Share is MXN57.66 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OPKO Health (MEX:OPK) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of MXN26.20 is trading 36.7% above its estimated GF Value™ of MXN19.16. GuruFocus considers OPKO Health to be Significantly Overvalued.

Key valuation signals for MEX:OPK:

  • Cyclically Adjusted Book per Share: MXN57.66
  • GF Value™: MXN19.16 vs. price of MXN26.20 (36.7% above fair value)
  • GF Score™: 53/100 with 4 warning signs

No single metric tells the full story. See the MEX:OPK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
53GF Score

Get the complete analysis for MEX:OPK

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN26.20
Price
MXN19.16
GF Value