ProQR Therapeutics NV (MEX:PRQRN) Cyclically Adjusted Book per Share: MXN40.00 (As of Mar. 2026)


MEX:PRQRN ProQR Therapeutics NV MEX:PRQRN
44 GF Score
Price MXN36.00
GF Value MXN40.07
! 5 Warning Signs
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What is ProQR Therapeutics NV Cyclically Adjusted Book per Share?

ProQR Therapeutics NV MEX:PRQRN 44 Cyclically Adjusted Book per Share is MXN40.00 as of Mar. 2026. GuruFocus rates MEX:PRQRN with a GF Score™ of 44/100 and a GF Value™ of MXN40.07. The stock has 5 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

ProQR Therapeutics NV's adjusted book value per share for the three months ended in Mar. 2026 was MXN7.439. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is MXN40.00 for the trailing ten years ended in Mar. 2026.

During the past 12 months, ProQR Therapeutics NV's average Cyclically Adjusted Book Growth Rate was -21.70% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

As of today (2026-06-25), ProQR Therapeutics NV's current stock price is MXN36.00. ProQR Therapeutics NV's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 was MXN40.00. ProQR Therapeutics NV's Cyclically Adjusted PB Ratio of today is 0.90.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of ProQR Therapeutics NV was 1.68. The lowest was 0.42. And the median was 0.79.


ProQR Therapeutics NV  (MEX:PRQRN) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

ProQR Therapeutics NV's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=36.00/40.00
=0.90

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of ProQR Therapeutics NV was 1.68. The lowest was 0.42. And the median was 0.79.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


ProQR Therapeutics NV Cyclically Adjusted Book per Share Related Terms


ProQR Therapeutics NV Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for ProQR Therapeutics NV's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

ProQR Therapeutics NV Cyclically Adjusted Book per Share Chart

ProQR Therapeutics NV Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 38.05 32.74 34.04

ProQR Therapeutics NV Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 62.26 38.12 34.65 34.04 40.00

MEX:PRQRN vs GALT, HRTX, PLYX: Cyclically Adjusted Book per Share Comparison

For the Biotechnology subindustry, ProQR Therapeutics NV's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


ProQR Therapeutics NV Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, ProQR Therapeutics NV's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where ProQR Therapeutics NV's Cyclically Adjusted PB Ratio falls into.


MEX:PRQRN
44GF Score
ProQR Therapeutics NV MEX:PRQRN
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

ProQR Therapeutics NV Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, ProQR Therapeutics NV's adjusted Book Value per Share data for the three months ended in Mar. 2026 was:

Adj_Book= Book Value per Share /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=7.439/135.2700*135.2700
=7.439

Current CPI (Mar. 2026) = 135.2700.

ProQR Therapeutics NV Quarterly Data

Book Value per Share CPI Adj_Book
201606 63.132 100.260 85.177
201609 57.103 100.570 76.805
201612 49.497 100.710 66.483
201703 38.594 101.440 51.465
201706 30.991 101.370 41.355
201709 27.820 102.030 36.883
201712 28.660 101.970 38.019
201803 20.736 102.470 27.373
201806 16.440 103.100 21.570
201809 57.827 103.950 75.250
201812 53.392 103.970 69.466
201903 45.722 105.370 58.696
201906 39.398 105.840 50.353
201909 33.452 106.700 42.409
201912 39.736 106.800 50.329
202003 42.452 106.850 53.743
202006 41.519 107.510 52.240
202009 35.609 107.880 44.650
202012 27.519 107.850 34.515
202103 23.693 108.870 29.438
202106 42.233 109.670 52.091
202109 43.722 110.790 53.383
202112 37.012 114.010 43.914
202203 30.983 119.460 35.083
202206 26.037 119.050 29.584
202209 18.100 126.890 19.295
202212 17.138 124.940 18.555
202303 14.070 124.720 15.260
202306 11.885 125.830 12.777
202309 10.615 127.160 11.292
202312 9.417 126.450 10.074
202403 7.692 128.580 8.092
202406 7.932 129.910 8.259
202409 6.684 131.610 6.870
202412 18.382 131.630 18.890
202503 16.573 133.330 16.814
202506 13.809 133.960 13.944
202509 11.664 135.920 11.608
202512 9.880 135.270 9.880
202603 7.439 135.270 7.439

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of MXN40.00 mean?
ProQR Therapeutics NV (MEX:PRQRN) has a Cyclically Adjusted Book per Share of MXN40.00 as of Mar. 2026. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on ProQR Therapeutics NV and its competitors.
Is ProQR Therapeutics NV's Cyclically Adjusted Book per Share too high?
ProQR Therapeutics NV's current Cyclically Adjusted Book per Share is MXN40.00. Overall, ProQR Therapeutics NV has a GF Score™ of 44/100, reflecting its overall financial health beyond just this single metric.
How does ProQR Therapeutics NV's Cyclically Adjusted Book per Share compare to GALT and HRTX?
ProQR Therapeutics NV's Cyclically Adjusted Book per Share of MXN40.00 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Biotechnology company?
A good Cyclically Adjusted Book per Share depends on the Biotechnology industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on ProQR Therapeutics NV and its competitors. ProQR Therapeutics NV's current Cyclically Adjusted Book per Share is MXN40.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is ProQR Therapeutics NV stock overvalued right now?
ProQR Therapeutics NV (MEX:PRQRN) has a current Cyclically Adjusted Book per Share of MXN40.00. The stock's GF Value™ is MXN40.07, compared to a current price of MXN36.00 — trading 10.2% below its estimated fair value. The current Cyclically Adjusted Book per Share is MXN40.00. ProQR Therapeutics NV's overall GF Score™ is 44/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For ProQR Therapeutics NV (MEX:PRQRN), the current Cyclically Adjusted Book per Share is MXN40.00 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is ProQR Therapeutics NV (MEX:PRQRN) Overvalued in 2026?

Based on GuruFocus' analysis, ProQR Therapeutics NV stock appears to be undervalued. The current stock price of MXN36.00 is trading 10.2% below its estimated GF Value™ of MXN40.07.

Key valuation signals for MEX:PRQRN:

  • Cyclically Adjusted Book per Share: MXN40.00
  • GF Value™: MXN40.07 vs. price of MXN36.00 (10.2% below fair value)
  • GF Score™: 44/100 with 5 warning signs

No single metric tells the full story. See the MEX:PRQRN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


ProQR Therapeutics NV Business Description

Other Exchanges PRQR:USA0PQ:Germany
Address Zernikedreef 9, Leiden, ZH, NLD, 2333 CK
ProQR Therapeutics NV is a biopharmaceutical company. It discovers and develops RNA therapeutics for patients with severe genetic rare diseases such as cystic fibrosis, Leber congenital amaurosis type 10, and dystrophic epidermolysis bullosa. The only reportable segment of the company is the discovery and development of different, RNA-based therapeutics. Geographically, the company operates in United States.
44GF Score

Get the complete analysis for MEX:PRQRN

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN36.00
Price
MXN40.07
GF Value