OPK (OPKO Health) Cyclically Adjusted Book per Share: $3.13 (As of Mar. 2026)


OPK OPKO Health Inc OPK
56 GF Score
Price $1.51
GF Value $1.06
Valuation Significantly Overvalued
! 7 Warning Signs
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What is OPKO Health Cyclically Adjusted Book per Share?

OPKO Health OPK -0.33% 56 Cyclically Adjusted Book per Share is $3.13 as of Mar. 2026. GuruFocus rates OPK with a GF Score™ of 56/100 and a GF Value™ of $1.06 (Significantly Overvalued). The stock has 7 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

OPKO Health's adjusted book value per share for the three months ended in Mar. 2026 was $1.595. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $3.13 for the trailing ten years ended in Mar. 2026.

During the past 12 months, OPKO Health's average Cyclically Adjusted Book Growth Rate was -4.90% per year. During the past 3 years, the average Cyclically Adjusted Book Growth Rate was 0.10% per year. During the past 5 years, the average Cyclically Adjusted Book Growth Rate was 5.20% per year. During the past 10 years, the average Cyclically Adjusted Book Growth Rate was 14.00% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted Book Growth Rate of OPKO Health was 36.20% per year. The lowest was -23.60% per year. And the median was 8.00% per year.

As of today (2026-06-30), OPKO Health's current stock price is $1.505. OPKO Health's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 was $3.13. OPKO Health's Cyclically Adjusted PB Ratio of today is 0.48.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of OPKO Health was 11.32. The lowest was 0.27. And the median was 1.02.


OPKO Health  (NAS:OPK) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

OPKO Health's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=1.505/3.13
=0.48

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of OPKO Health was 11.32. The lowest was 0.27. And the median was 1.02.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


OPKO Health Cyclically Adjusted Book per Share Related Terms


OPKO Health Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for OPKO Health's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health Cyclically Adjusted Book per Share Chart

OPKO Health Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 2.81 3.15 3.24 3.26 3.16

OPKO Health Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 3.29 3.30 3.25 3.16 3.13

OPK vs PSNL, CDNA, CSTL: Cyclically Adjusted Book per Share Comparison

For the Diagnostics & Research subindustry, OPKO Health's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OPKO Health Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where OPKO Health's Cyclically Adjusted PB Ratio falls into.


OPK
56GF Score
OPKO Health Inc OPK
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
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OPKO Health Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, OPKO Health's adjusted Book Value per Share data for the three months ended in Mar. 2026 was:

Adj_Book= Book Value per Share /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=1.595/330.2130*330.2130
=1.595

Current CPI (Mar. 2026) = 330.2130.

OPKO Health Quarterly Data

Book Value per Share CPI Adj_Book
201606 3.680 241.018 5.042
201609 3.777 241.428 5.166
201612 3.749 241.432 5.128
201703 3.769 243.801 5.105
201706 3.766 244.955 5.077
201709 3.734 246.819 4.996
201712 3.295 246.524 4.414
201803 3.259 249.554 4.312
201806 3.235 251.989 4.239
201809 3.195 252.439 4.179
201812 3.055 251.233 4.015
201903 2.863 254.202 3.719
201906 2.776 256.143 3.579
201909 2.667 256.759 3.430
201912 2.411 256.974 3.098
202003 2.312 258.115 2.958
202006 2.371 257.797 3.037
202009 2.424 260.280 3.075
202012 2.493 260.474 3.160
202103 2.532 264.877 3.157
202106 2.558 271.696 3.109
202109 2.591 274.310 3.119
202112 2.473 278.802 2.929
202203 2.370 287.504 2.722
202206 2.227 296.311 2.482
202209 2.108 296.808 2.345
202212 2.021 296.797 2.249
202303 2.008 301.836 2.197
202306 1.986 305.109 2.149
202309 1.869 307.789 2.005
202312 1.797 306.746 1.934
202403 1.797 312.332 1.900
202406 2.001 314.175 2.103
202409 2.056 315.301 2.153
202412 2.033 315.605 2.127
202503 1.953 319.799 2.017
202506 1.663 322.561 1.702
202509 1.698 324.800 1.726
202512 1.670 324.054 1.702
202603 1.595 330.213 1.595

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of $3.13 mean?
OPKO Health (OPK) has a Cyclically Adjusted Book per Share of $3.13 as of Mar. 2026. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors.
Is OPKO Health's Cyclically Adjusted Book per Share too high?
OPKO Health's current Cyclically Adjusted Book per Share is $3.13. Overall, OPKO Health has a GF Score™ of 56/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OPKO Health's Cyclically Adjusted Book per Share compare to PSNL and CDNA?
OPKO Health's Cyclically Adjusted Book per Share of $3.13 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Medical Diagnostics & Research company?
A good Cyclically Adjusted Book per Share depends on the Medical Diagnostics & Research industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on OPKO Health and its competitors. OPKO Health's current Cyclically Adjusted Book per Share is $3.13. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OPKO Health stock overvalued right now?
Based on GuruFocus' analysis, OPKO Health (OPK) is currently considered Significantly Overvalued. The stock's GF Value™ is $1.06, compared to a current price of $1.51 — trading 42% above its estimated fair value. The current Cyclically Adjusted Book per Share is $3.13. OPKO Health's overall GF Score™ is 56/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For OPKO Health (OPK), the current Cyclically Adjusted Book per Share is $3.13 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OPKO Health (OPK) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of $1.51 is trading 42% above its estimated GF Value™ of $1.06. GuruFocus considers OPKO Health to be Significantly Overvalued.

Key valuation signals for OPK:

  • Cyclically Adjusted Book per Share: $3.13
  • GF Value™: $1.06 vs. price of $1.51 (42% above fair value)
  • GF Score™: 56/100 with 7 warning signs

No single metric tells the full story. See the OPK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
56GF Score

Get the complete analysis for OPK

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.51
Price
$1.06
GF Value