SIGY (Sigyn Therapeutics) Cyclically Adjusted Book per Share: $-137.66 (As of Sep. 2025)


What is Sigyn Therapeutics Cyclically Adjusted Book per Share?

Sigyn Therapeutics SIGY +22.62% Cyclically Adjusted Book per Share is $-137.66 as of Sep. 2025. The stock has 3 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

Sigyn Therapeutics's adjusted book value per share for the three months ended in Sep. 2025 was $-3.687. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $-137.66 for the trailing ten years ended in Sep. 2025.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

As of today (2026-07-05), Sigyn Therapeutics's current stock price is $0.045. Sigyn Therapeutics's Cyclically Adjusted Book per Share for the quarter that ended in Sep. 2025 was $-137.66. Sigyn Therapeutics's Cyclically Adjusted PB Ratio of today is .


Sigyn Therapeutics  (OTCPK:SIGY) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


Sigyn Therapeutics Cyclically Adjusted Book per Share Related Terms


Sigyn Therapeutics Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for Sigyn Therapeutics's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Sigyn Therapeutics Cyclically Adjusted Book per Share Chart

Sigyn Therapeutics Annual Data
Trend Dec15 Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 -140.42

Sigyn Therapeutics Quarterly Data
Dec20 Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -139.63 -140.42 -138.71 -136.50 -137.66

SIGY vs RGBP, ENDV, VRTX: Cyclically Adjusted Book per Share Comparison

For the Biotechnology subindustry, Sigyn Therapeutics's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Sigyn Therapeutics Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Sigyn Therapeutics's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Sigyn Therapeutics's Cyclically Adjusted PB Ratio falls into.



Sigyn Therapeutics Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Sigyn Therapeutics's adjusted Book Value per Share data for the three months ended in Sep. 2025 was:

Adj_Book= Book Value per Share /CPI of Sep. 2025 (Change)*Current CPI (Sep. 2025)
=-3.687/324.8000*324.8000
=-3.687

Current CPI (Sep. 2025) = 324.8000.

Sigyn Therapeutics Quarterly Data

Book Value per Share CPI Adj_Book
201512 -196.833 236.525 -270.294
201603 -69.167 238.132 -94.340
201606 -162.500 241.018 -218.988
201609 -207.000 241.428 -278.483
201612 -98.857 241.432 -132.993
201703 -174.286 243.801 -232.190
201706 -213.875 244.955 -283.589
201709 -373.500 246.819 -491.505
201712 -232.667 246.524 -306.543
201803 -240.100 249.554 -312.495
201806 -246.400 251.989 -317.596
201809 -223.500 252.439 -287.566
201812 -265.357 251.233 -343.060
201903 -261.500 254.202 -334.125
201906 -269.857 256.143 -342.190
201909 -279.786 256.759 -353.929
201912 -175.786 256.974 -222.183
202003 -171.267 258.115 -215.514
202006 -166.813 257.797 -210.169
202009 -176.188 260.280 -219.863
202012 0.113 260.474 0.141
202103 -0.091 264.877 -0.112
202106 1.067 271.696 1.276
202109 0.390 274.310 0.462
202112 -0.284 278.802 -0.331
202203 -0.785 287.504 -0.887
202206 -1.269 296.311 -1.391
202209 -1.869 296.808 -2.045
202212 -1.989 296.797 -2.177
202303 -2.197 301.836 -2.364
202306 -2.750 305.109 -2.927
202309 -3.233 307.789 -3.412
202312 -2.650 306.746 -2.806
202403 -3.282 312.332 -3.413
202406 -2.905 314.175 -3.003
202409 -2.761 315.301 -2.844
202412 -2.778 315.605 -2.859
202503 -3.081 319.799 -3.129
202506 -3.388 322.561 -3.412
202509 -3.687 324.800 -3.687

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of $-137.66 mean?
Sigyn Therapeutics (SIGY) has a Cyclically Adjusted Book per Share of $-137.66 as of Sep. 2025. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on Sigyn Therapeutics and its competitors.
Is Sigyn Therapeutics' Cyclically Adjusted Book per Share too high?
Sigyn Therapeutics' current Cyclically Adjusted Book per Share is $-137.66.
How does Sigyn Therapeutics' Cyclically Adjusted Book per Share compare to RGBP and ENDV?
Sigyn Therapeutics' Cyclically Adjusted Book per Share of $-137.66 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Biotechnology company?
A good Cyclically Adjusted Book per Share depends on the Biotechnology industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on Sigyn Therapeutics and its competitors. Sigyn Therapeutics's current Cyclically Adjusted Book per Share is $-137.66. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Sigyn Therapeutics stock overvalued right now?
Sigyn Therapeutics (SIGY) has a current Cyclically Adjusted Book per Share of $-137.66. The current Cyclically Adjusted Book per Share is $-137.66. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For Sigyn Therapeutics (SIGY), the current Cyclically Adjusted Book per Share is $-137.66 as of Sep. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Sigyn Therapeutics Business Description

Address 2468 Historic Decatur Road, Suite 140, San Diego, CA, USA, 92106
Sigyn Therapeutics Inc is a development-stage therapeutic technology company. Its business focus is the clinical advancement of Sigyn Therapy, a multi-function blood purification technology designed to overcome the limitations of previous drugs and devices to treat life-threatening inflammatory disorders, including sepsis, the cause of hospital deaths world-wide. To support widespread implementation, the company designed Sigyn Therapy to be a single-use disposable device that is deployable on the world-wide infrastructure of hemodialysis and continuous renal replacement therapy machines already located in hospitals and clinics.