OPKO Health (FRA:XCY) Cyclically Adjusted FCF per Share: €-0.15 (As of Mar. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

FRA:XCY OPKO Health Inc FRA:XCY
57 GF Score
Price €1.02
GF Value €0.89
! 4 Warning Signs
View Full Analysis

What is OPKO Health Cyclically Adjusted FCF per Share?

OPKO Health FRA:XCY 57 Cyclically Adjusted FCF per Share is €-0.15 as of Mar. 2026. GuruFocus rates FRA:XCY with a GF Score™ of 57/100 and a GF Value™ of €0.89. The stock has 4 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted FCF per Share and the Cyclically Adjusted Price-to-FCF. The Cyclically Adjusted FCF per Share is the average of the inflation adjusted Free Cash Flow per Share of a company over the past 10 years.

OPKO Health's adjusted free cash flow per share for the three months ended in Mar. 2026 was €-0.024. Add all the adjusted free cash flow per share for the past 10 years together and divide the count will get our Cyclically Adjusted FCF per Share, which is €-0.15 for the trailing ten years ended in Mar. 2026.

During the past 3 years, the average Cyclically Adjusted FCF Growth Rate was -17.80% per year. During the past 5 years, the average Cyclically Adjusted FCF Growth Rate was -8.50% per year. During the past 10 years, the average Cyclically Adjusted FCF Growth Rate was -6.70% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted FCF Growth Rate using Cyclically Adjusted FCF per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted FCF Growth Rate of OPKO Health was 23.90% per year. The lowest was -17.80% per year. And the median was 6.80% per year.

As of today (2026-07-25), OPKO Health's current stock price is €1.02. OPKO Health's Cyclically Adjusted FCF per Share for the quarter that ended in Mar. 2026 was €-0.15. OPKO Health's Cyclically Adjusted Price-to-FCF of today is .


OPKO Health  (FRA:XCY) Cyclically Adjusted FCF per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted FCF per Share may underestimate the company's free cash flow. Cyclically Adjusted Price-to-FCF can seem to be too high even the actual Price-to-Free-Cash-Flow is low.

For the Cyclically Adjusted Price-to-FCF, the free cash flow per share of the past 10 years are inflation-adjusted and averaged. The result is used for P/FCF calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted Price-to-FCF is also called CAPFCF Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Price-to-FCF. The Cyclically Adjusted FCF per Share is the average of the inflation adjusted free cash flow per share of a company over the past 10 years.


Be Aware

Cyclically Adjusted Price-to-FCF works better for cyclical companies. It gives you a better idea on the company's real free cash flow value.


OPKO Health Cyclically Adjusted FCF per Share Related Terms


OPKO Health Cyclically Adjusted FCF per Share Historical Data

* Premium members only.

The historical data trend for OPKO Health's Cyclically Adjusted FCF per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health Cyclically Adjusted FCF per Share Chart

OPKO Health Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted FCF per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only -0.09 -0.10 -0.09 -0.09 -0.16

OPKO Health Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted FCF per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.16 -0.15 -0.15 -0.16 -0.15

FRA:XCY vs PSNL, CDNA, CSTL: Cyclically Adjusted FCF per Share Comparison

For the Diagnostics & Research subindustry, OPKO Health's Cyclically Adjusted Price-to-FCF, along with its competitors' market caps and Cyclically Adjusted Price-to-FCF data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OPKO Health Cyclically Adjusted Price-to-FCF vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's Cyclically Adjusted Price-to-FCF distribution charts can be found below:

* The bar in red indicates where OPKO Health's Cyclically Adjusted Price-to-FCF falls into.


FRA:XCY
57GF Score
OPKO Health Inc FRA:XCY
Cyclically Adjusted FCF per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

OPKO Health Cyclically Adjusted FCF per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted FCF per Share and the Cyclically Adjusted Price-to-FCF. The Cyclically Adjusted FCF per Share is the average of the inflation adjusted Free Cash Flow per Share of a company over the past 10 years.

What is Cyclically Adjusted FCF per Share? How do we calculate Cyclically Adjusted FCF per Share?

Cyclically Adjusted FCF per Share is the average of the inflation adjusted Free Cash Flow per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted FCF per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the free cash flow per share from 2001 through 2010.

We adjusted the 2001 free cash flow per share data with the total inflation from 2001 through 2010 to the equivalent free cash flow in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's free cash flow is $1 a share in 2001, then the 2001's equivalent free cash flow in 2010 is $1.4 a share. If Wal-Mart's free cash flow is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 free cash flow in 2010 is $1.35. So on and so forth, you get the equivalent free cash flow per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted FCF per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, OPKO Health's adjusted Free Cash Flow per Share data for the three months ended in Mar. 2026 was:

Adj_FreeCashFlowPerShare= Free Cash Flow per Share /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=-0.024/330.2130*330.2130
=-0.024

Current CPI (Mar. 2026) = 330.2130.

OPKO Health Quarterly Data

Free Cash Flow per Share CPI Adj_FreeCashFlowPerShare
201606 0.064 241.018 0.088
201609 -0.066 241.428 -0.090
201612 0.047 241.432 0.064
201703 -0.073 243.801 -0.099
201706 -0.047 244.955 -0.063
201709 -0.079 246.819 -0.106
201712 -0.019 246.524 -0.025
201803 -0.060 249.554 -0.079
201806 -0.037 251.989 -0.048
201809 -0.052 252.439 -0.068
201812 -0.058 251.233 -0.076
201903 -0.078 254.202 -0.101
201906 -0.086 256.143 -0.111
201909 -0.041 256.759 -0.053
201912 -0.072 256.974 -0.093
202003 -0.069 258.115 -0.088
202006 -0.036 257.797 -0.046
202009 0.071 260.280 0.090
202012 0.035 260.474 0.044
202103 0.022 264.877 0.027
202106 -0.031 271.696 -0.038
202109 0.034 274.310 0.041
202112 -0.017 278.802 -0.020
202203 -0.035 287.504 -0.040
202206 -0.022 296.311 -0.025
202209 -0.054 296.808 -0.060
202212 -0.048 296.797 -0.053
202303 -0.032 301.836 -0.035
202306 -0.008 305.109 -0.009
202309 0.036 307.789 0.039
202312 -0.050 306.746 -0.054
202403 -0.052 312.332 -0.055
202406 -0.045 314.175 -0.047
202409 -0.077 315.301 -0.081
202412 -0.070 315.605 -0.073
202503 -0.052 319.799 -0.054
202506 -0.095 322.561 -0.097
202509 -0.041 324.800 -0.042
202512 -0.032 324.054 -0.033
202603 -0.024 330.213 -0.024

Add all the adjusted free cash flow per share together and divide 10 will get our Cyclically Adjusted FCF per Share.

What does a Cyclically Adjusted FCF per Share of €-0.15 mean?
OPKO Health (FRA:XCY) has a Cyclically Adjusted FCF per Share of €-0.15 as of Mar. 2026. Cyclically Adjusted FCF per Share represents the company's inflation-adjusted FCF per share over a 10-year period. View historical data on OPKO Health and its competitors.
Is OPKO Health's Cyclically Adjusted FCF per Share too high?
OPKO Health's current Cyclically Adjusted FCF per Share is €-0.15. Overall, OPKO Health has a GF Score™ of 57/100, reflecting its overall financial health beyond just this single metric.
How does OPKO Health's Cyclically Adjusted FCF per Share compare to PSNL and CDNA?
OPKO Health's Cyclically Adjusted FCF per Share of €-0.15 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted FCF per Share for a Medical Diagnostics & Research company?
A good Cyclically Adjusted FCF per Share depends on the Medical Diagnostics & Research industry context. However, Cyclically Adjusted FCF per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted FCF per Share mean?
A high Cyclically Adjusted FCF per Share can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted FCF per Share represents the company's inflation-adjusted FCF per share over a 10-year period. View historical data on OPKO Health and its competitors. OPKO Health's current Cyclically Adjusted FCF per Share is €-0.15. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OPKO Health stock overvalued right now?
OPKO Health (FRA:XCY) has a current Cyclically Adjusted FCF per Share of €-0.15. The stock's GF Value™ is €0.89, compared to a current price of €1.02 — trading 14.6% above its estimated fair value. The current Cyclically Adjusted FCF per Share is €-0.15. OPKO Health's overall GF Score™ is 57/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted FCF per Share calculated?
Cyclically Adjusted FCF per Share is calculated from a company's financial statements. For OPKO Health (FRA:XCY), the current Cyclically Adjusted FCF per Share is €-0.15 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OPKO Health (FRA:XCY) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of €1.02 is trading 14.6% above its estimated GF Value™ of €0.89.

Key valuation signals for FRA:XCY:

  • Cyclically Adjusted FCF per Share: €-0.15
  • GF Value™: €0.89 vs. price of €1.02 (14.6% above fair value)
  • GF Score™: 57/100 with 4 warning signs

No single metric tells the full story. See the FRA:XCY stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
57GF Score

Get the complete analysis for FRA:XCY

Cyclically Adjusted FCF per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€1.02
Price
€0.89
GF Value