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Spyre TherapeuticsFRA:3920 29 Cyclically Adjusted PB Ratio is 1.76 as of Aug. 10, 2026, which is 259% above its 10-year median of 0.49. GuruFocus rates FRA:3920 with a GF Score™ of 29/100 and a GF Value™ of €1.98 (Significantly Overvalued). The stock has 4 warning signs investors should review. Among 692 Biotechnology companies, Spyre Therapeutics ranks worse than 52.46% on this metric.
The historical rank and industry rank for Spyre Therapeutics's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:3920'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.18 Med: 0.49 Max: 2.03
Current: 1.83
During the past years, Spyre Therapeutics's highest Cyclically Adjusted PB Ratio was 2.03. The lowest was 0.18. And the median was 0.49.
FRA:3920's Cyclically Adjusted PB Ratio is ranked worse than 52.46% of 692
companies
in the Biotechnology industry
Industry Median: 1.615
vs FRA:3920: 1.83
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Spyre Therapeutics's adjusted book value per share data for the three months ended in Jun. 2026 was €9.739. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €51.08 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Spyre Therapeutics (FRA:3920) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Spyre Therapeutics Cyclically Adjusted PB Ratio Related Terms
Spyre Therapeutics Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Spyre Therapeutics's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Spyre Therapeutics Cyclically Adjusted PB Ratio Chart
FRA:3920 vs CRNX, PTGX, PRAX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Spyre Therapeutics's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spyre Therapeutics Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spyre Therapeutics's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Spyre Therapeutics's Cyclically Adjusted PB Ratio falls into.
Spyre Therapeutics Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Spyre Therapeutics's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 1.76 mean?
Spyre Therapeutics (FRA:3920) has a Cyclically Adjusted PB Ratio of 1.76 as of Aug. 10, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Spyre Therapeutics and its competitors. This is 259% above median its historical median of 0.49. Over the past decade, Spyre Therapeutics' Cyclically Adjusted PB Ratio has ranged from 0.18 to 2.03. According to the industry distribution chart, Spyre Therapeutics ranks #363 out of 692 companies in the Biotechnology industry, placing it in the top 52.5%.
Is Spyre Therapeutics' Cyclically Adjusted PB Ratio too high?
Spyre Therapeutics' current Cyclically Adjusted PB Ratio of 1.76 is 259% above median its 10-year median of 0.49. Over the past 10 years, this metric has ranged from a low of 0.18 to a high of 2.03. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.62. Spyre Therapeutics' value of 1.76 is 9% above this industry median. Based on the distribution chart, Spyre Therapeutics ranks #363 out of 692 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Spyre Therapeutics has a GF Score™ of 29/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' Cyclically Adjusted PB Ratio compare to CRNX and PTGX?
According to the Biotechnology industry distribution chart, Spyre Therapeutics ranks #363 out of 692 companies for Cyclically Adjusted PB Ratio. This places Spyre Therapeutics in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.62. Spyre Therapeutics' value of 1.76 is 9% above this benchmark. Historically, Spyre Therapeutics' own Cyclically Adjusted PB Ratio has ranged from 0.18 to 2.03 over the past decade. While the company's 10-year median is 0.49 vs. the industry median of 1.62, Spyre Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.62, based on 692 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Spyre Therapeutics's current Cyclically Adjusted PB Ratio of 1.76 is 9% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Spyre Therapeutics and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.62 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Spyre Therapeutics's current Cyclically Adjusted PB Ratio is 1.76, which is 259% above median its own 10-year median of 0.49. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Spyre Therapeutics (FRA:3920) is currently considered Significantly Overvalued. The stock's GF Value™ is €1.98, compared to a current price of €90.00 — trading 4445.5% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 1.76, which is 259% above median its 10-year median of 0.49 and 9% above the Biotechnology industry median of 1.62. Spyre Therapeutics' overall GF Score™ is 29/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Spyre Therapeutics (FRA:3920), the current Cyclically Adjusted PB Ratio is 1.76 as of Aug. 10, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Spyre Therapeutics (FRA:3920) Overvalued in 2026?
Based on GuruFocus' analysis, Spyre Therapeutics stock appears to be overvalued.
The current stock price of €90.00 is trading 4445.5% above its estimated GF Value™ of €1.98.
GuruFocus considers Spyre Therapeutics to be Significantly Overvalued.
Key valuation signals for FRA:3920:
Cyclically Adjusted PB Ratio: 1.76 (259% above median its 10-year median of 0.49)
GF Value™: €1.98 vs. price of €90.00 (4445.5% above fair value)
Industry Position: 9% above the Biotechnology median (#363 of 692)
No single metric tells the full story. See the FRA:3920 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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