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Crinetics PharmaceuticalsFRA:6Z4 -0.22%35 Cyclically Adjusted PB Ratio is 16.57 as of Aug. 15, 2026, which is 158% above its 10-year median of 6.42. GuruFocus rates FRA:6Z4 with a GF Score™ of 35/100 and a GF Value™ of €810.53 (Possible Value Trap). The stock has 6 warning signs investors should review. Among 692 Biotechnology companies, Crinetics Pharmaceuticals ranks worse than 90.03% on this metric.
The historical rank and industry rank for Crinetics Pharmaceuticals's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:6Z4'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 4.97 Med: 6.42 Max: 12.52
Current: 12.52
During the past 10 years, Crinetics Pharmaceuticals's highest Cyclically Adjusted PB Ratio was 12.52. The lowest was 4.97. And the median was 6.42.
FRA:6Z4's Cyclically Adjusted PB Ratio is ranked worse than 90.03% of 692
companies
in the Biotechnology industry
Industry Median: 1.62
vs FRA:6Z4: 12.52
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Crinetics Pharmaceuticals's adjusted book value per share data of for the fiscal year that ended in Dec25 was €8.865. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €4.33 for the trailing ten years ended in Dec25.
Shiller PE for Stocks: The True Measure of Stock Valuation
Crinetics Pharmaceuticals (FRA:6Z4) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Crinetics Pharmaceuticals Cyclically Adjusted PB Ratio Related Terms
Crinetics Pharmaceuticals Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Crinetics Pharmaceuticals's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Crinetics Pharmaceuticals Cyclically Adjusted PB Ratio Chart
FRA:6Z4 vs SYRE, PTGX, PRAX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Crinetics Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Crinetics Pharmaceuticals Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Crinetics Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Crinetics Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.
Crinetics Pharmaceuticals Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 16.57 mean?
Crinetics Pharmaceuticals (FRA:6Z4) has a Cyclically Adjusted PB Ratio of 16.57 as of Aug. 15, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Crinetics Pharmaceuticals and its competitors. This is 158% above median its historical median of 6.42. Over the past decade, Crinetics Pharmaceuticals' Cyclically Adjusted PB Ratio has ranged from 4.97 to 12.52. According to the industry distribution chart, Crinetics Pharmaceuticals ranks #623 out of 692 companies in the Biotechnology industry, placing it in the top 90%.
Is Crinetics Pharmaceuticals' Cyclically Adjusted PB Ratio too high?
Crinetics Pharmaceuticals' current Cyclically Adjusted PB Ratio of 16.57 is 158% above median its 10-year median of 6.42. Over the past 10 years, this metric has ranged from a low of 4.97 to a high of 12.52. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.62. Crinetics Pharmaceuticals' value of 16.57 is 922.8% above this industry median. Based on the distribution chart, Crinetics Pharmaceuticals ranks #623 out of 692 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Crinetics Pharmaceuticals has a GF Score™ of 35/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Crinetics Pharmaceuticals' Cyclically Adjusted PB Ratio compare to SYRE and PTGX?
According to the Biotechnology industry distribution chart, Crinetics Pharmaceuticals ranks #623 out of 692 companies for Cyclically Adjusted PB Ratio. This places Crinetics Pharmaceuticals in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.62. Crinetics Pharmaceuticals' value of 16.57 is 922.8% above this benchmark. Historically, Crinetics Pharmaceuticals' own Cyclically Adjusted PB Ratio has ranged from 4.97 to 12.52 over the past decade. While the company's 10-year median is 6.42 vs. the industry median of 1.62, Crinetics Pharmaceuticals has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.62, based on 692 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Crinetics Pharmaceuticals's current Cyclically Adjusted PB Ratio of 16.57 is 922.8% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Crinetics Pharmaceuticals and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.62 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Crinetics Pharmaceuticals's current Cyclically Adjusted PB Ratio is 16.57, which is 158% above median its own 10-year median of 6.42. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Crinetics Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Crinetics Pharmaceuticals (FRA:6Z4) is currently considered Possible Value Trap. The stock's GF Value™ is €810.53, compared to a current price of €71.76 — trading 91.1% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 16.57, which is 158% above median its 10-year median of 6.42 and 922.8% above the Biotechnology industry median of 1.62. Crinetics Pharmaceuticals' overall GF Score™ is 35/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Crinetics Pharmaceuticals (FRA:6Z4), the current Cyclically Adjusted PB Ratio is 16.57 as of Aug. 15, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Crinetics Pharmaceuticals (FRA:6Z4) Overvalued in 2026?
Based on GuruFocus' analysis, Crinetics Pharmaceuticals stock appears to be undervalued.
The current stock price of €71.76 is trading 91.1% below its estimated GF Value™ of €810.53.
GuruFocus considers Crinetics Pharmaceuticals to be Possible Value Trap.
Key valuation signals for FRA:6Z4:
Cyclically Adjusted PB Ratio: 16.57 (158% above median its 10-year median of 6.42)
GF Value™: €810.53 vs. price of €71.76 (91.1% below fair value)
Industry Position: 922.8% above the Biotechnology median (#623 of 692)
No single metric tells the full story. See the FRA:6Z4 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Crinetics Pharmaceuticals Inc is a commercial-stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. Its main product, Palsonify (paltusotine), is a once-daily, oral treatment approved by the FDA for adults with acromegaly who have had an inadequate response to surgery and/or for whom surgery is not an option. Additionally, the company's development pipeline includes several programs, including a late-stage investigational candidate, atumelnant, currently in development for CAH and ADCS, and CRN09682, a NDC candidate that is being developed to treat SST2-expressing NETs and other SST2-expressing solid tumors.
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