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Guardant HealthGH +0.57%65 Cyclically Adjusted PB Ratio is 43.32 as of Aug. 05, 2026, which is 57% above its 10-year median of 27.60. GuruFocus rates GH with a GF Score™ of 65/100 and a GF Value™ of $65.16 (Significantly Overvalued). The stock has 3 warning signs investors should review. Among 131 Medical Diagnostics & Research companies, Guardant Health ranks worse than 97.71% on this metric.
The historical rank and industry rank for Guardant Health's Cyclically Adjusted PB Ratio or its related term are showing as below:
GH'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 22.93 Med: 27.6 Max: 43.05
Current: 43.05
During the past 10 years, Guardant Health's highest Cyclically Adjusted PB Ratio was 43.05. The lowest was 22.93. And the median was 27.60.
GH's Cyclically Adjusted PB Ratio is ranked worse than 97.71% of 131
companies
in the Medical Diagnostics & Research industry
Industry Median: 1.75
vs GH: 43.05
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Guardant Health's adjusted book value per share data of for the fiscal year that ended in Dec25 was $-0.760. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $3.69 for the trailing ten years ended in Dec25.
Shiller PE for Stocks: The True Measure of Stock Valuation
Guardant Health (NAS:GH) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Guardant Health Cyclically Adjusted PB Ratio Related Terms
Guardant Health Cyclically Adjusted PB Ratio Historical Data
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The historical data trend for Guardant Health's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Guardant Health Cyclically Adjusted PB Ratio Chart
GH vs MEDP, LH, DGX: Cyclically Adjusted PB Ratio Comparison
For the Diagnostics & Research subindustry, Guardant Health's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Guardant Health Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Guardant Health's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Guardant Health's Cyclically Adjusted PB Ratio falls into.
Guardant Health Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Guardant Health's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 43.32 mean?
Guardant Health (GH) has a Cyclically Adjusted PB Ratio of 43.32 as of Aug. 05, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Guardant Health and its competitors. This is 57% above median its historical median of 27.60. Over the past decade, Guardant Health's Cyclically Adjusted PB Ratio has ranged from 22.93 to 43.05. According to the industry distribution chart, Guardant Health ranks #128 out of 131 companies in the Medical Diagnostics & Research industry, placing it in the top 97.7%.
Is Guardant Health's Cyclically Adjusted PB Ratio too high?
Guardant Health's current Cyclically Adjusted PB Ratio of 43.32 is 57% above median its 10-year median of 27.60. Over the past 10 years, this metric has ranged from a low of 22.93 to a high of 43.05. The Medical Diagnostics & Research industry median Cyclically Adjusted PB Ratio is 1.75. Guardant Health's value of 43.32 is 2375.4% above this industry median. Based on the distribution chart, Guardant Health ranks #128 out of 131 companies in the Medical Diagnostics & Research industry, which is in the bottom quartile relative to peers. Overall, Guardant Health has a GF Score™ of 65/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Guardant Health's Cyclically Adjusted PB Ratio compare to MEDP and LH?
According to the Medical Diagnostics & Research industry distribution chart, Guardant Health ranks #128 out of 131 companies for Cyclically Adjusted PB Ratio. This places Guardant Health in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.75. Guardant Health's value of 43.32 is 2375.4% above this benchmark. Historically, Guardant Health's own Cyclically Adjusted PB Ratio has ranged from 22.93 to 43.05 over the past decade. While the company's 10-year median is 27.60 vs. the industry median of 1.75, Guardant Health has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Medical Diagnostics & Research company?
The median Cyclically Adjusted PB Ratio among Medical Diagnostics & Research companies is 1.75, based on 131 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Guardant Health's current Cyclically Adjusted PB Ratio of 43.32 is 2375.4% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Guardant Health and its competitors. For the Medical Diagnostics & Research industry, the median Cyclically Adjusted PB Ratio is 1.75 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Guardant Health's current Cyclically Adjusted PB Ratio is 43.32, which is 57% above median its own 10-year median of 27.60. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Guardant Health stock overvalued right now?
Based on GuruFocus' analysis, Guardant Health (GH) is currently considered Significantly Overvalued. The stock's GF Value™ is $65.16, compared to a current price of $159.84 — trading 145.3% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 43.32, which is 57% above median its 10-year median of 27.60 and 2375.4% above the Medical Diagnostics & Research industry median of 1.75. Guardant Health's overall GF Score™ is 65/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Guardant Health (GH), the current Cyclically Adjusted PB Ratio is 43.32 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Guardant Health (GH) Overvalued in 2026?
Based on GuruFocus' analysis, Guardant Health stock appears to be overvalued.
The current stock price of $159.84 is trading 145.3% above its estimated GF Value™ of $65.16.
GuruFocus considers Guardant Health to be Significantly Overvalued.
Key valuation signals for GH:
Cyclically Adjusted PB Ratio: 43.32 (57% above median its 10-year median of 27.60)
GF Value™: $65.16 vs. price of $159.84 (145.3% above fair value)
Industry Position: 2375.4% above the Medical Diagnostics & Research median (#128 of 131)
No single metric tells the full story. See the GH stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Guardant Health, based in Redwood City, California, is a leader in liquid-based cancer tests for clinical and research use. The company's main franchises are Guardant360 for genomic profiling of tumors, Reveal for molecular residual disease testing, and Shield for colorectal cancer screening. Additionally, Guardant offers research development services such as regulatory approval consultancy and clinical trial referrals.
65GF Score
Get the complete analysis for GH
Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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