Natera (HAM:45E) Cyclically Adjusted PB Ratio: (As of Aug. 21, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

HAM:45E Natera Inc HAM:45E
59 GF Score
Price €274.40
GF Value €179.22
Valuation Significantly Overvalued
! 6 Warning Signs
View Full Analysis

What is Natera Cyclically Adjusted PB Ratio?

Note: If the price history is too short, we do not calculate current Cyclically Adjusted PB Ratio for this stock. All the historical data is shown as the company's primary share's data instead.

Shiller PE for Stocks: The True Measure of Stock Valuation


Natera  (HAM:45E) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.


Natera Cyclically Adjusted PB Ratio Related Terms


Natera Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for Natera's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Natera Cyclically Adjusted PB Ratio Chart

Natera Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 19.07 39.66 46.48

Natera Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 36.41 33.82 46.48 38.38 49.56

HAM:45E vs : Cyclically Adjusted PB Ratio Comparison

For the Diagnostics & Research subindustry, Natera's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Natera Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Natera's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Natera's Cyclically Adjusted PB Ratio falls into.


HAM:45E
59GF Score
Natera Inc HAM:45E
Cyclically Adjusted PB Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Natera Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

Natera's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 is calculated as:

For example, Natera's adjusted Book Value per Share data for the three months ended in Jun. 2026 was:

Adj_Book=Book Value per Share/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=11.009/333.9520*333.9520
=11.009

Current CPI (Jun. 2026) = 333.9520.

Natera Quarterly Data

Book Value per Share CPI Adj_Book
201609 2.387 241.428 3.302
201612 1.917 241.432 2.652
201703 1.304 243.801 1.786
201706 0.852 244.955 1.162
201709 0.472 246.819 0.639
201712 0.397 246.524 0.538
201803 -0.058 249.554 -0.078
201806 -0.340 251.989 -0.451
201809 0.786 252.439 1.040
201812 0.455 251.233 0.605
201903 0.070 254.202 0.092
201906 1.176 256.143 1.533
201909 1.085 256.759 1.411
201912 3.216 256.974 4.179
202003 2.979 258.115 3.854
202006 3.389 257.797 4.390
202009 5.336 260.280 6.846
202012 4.635 260.474 5.943
202103 3.578 264.877 4.511
202106 2.805 271.696 3.448
202109 6.824 274.310 8.308
202112 6.077 278.802 7.279
202203 5.116 287.504 5.943
202206 4.340 296.311 4.891
202209 3.754 296.808 4.224
202212 5.988 296.797 6.738
202303 5.360 301.836 5.930
202306 4.825 305.109 5.281
202309 6.179 307.789 6.704
202312 5.869 306.746 6.390
202403 5.977 312.332 6.391
202406 6.299 314.175 6.696
202409 6.376 315.301 6.753
202412 8.607 315.605 9.107
202503 8.436 319.799 8.809
202506 7.900 322.561 8.179
202509 7.757 324.800 7.976
202512 10.469 324.054 10.789
202603 10.751 330.213 10.873
202606 11.009 333.952 11.009

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is Natera (HAM:45E) Overvalued in 2026?

Based on GuruFocus' analysis, Natera stock appears to be overvalued. The current stock price of €274.40 is trading 53.1% above its estimated GF Value™ of €179.22. GuruFocus considers Natera to be Significantly Overvalued.

Key valuation signals for HAM:45E:

  • Cyclically Adjusted PB Ratio:
  • GF Value™: €179.22 vs. price of €274.40 (53.1% above fair value)
  • GF Score™: 59/100 with 6 warning signs

No single metric tells the full story. See the HAM:45E stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Natera Business Description

Comparable Companies
Other Exchanges NTRA:USANTRA:Mexico
Address 13011 McCallen Pass, Building A Suite 100, Austin, TX, USA, 78753
Natera Inc is a diagnostic and research company with proprietary molecular and bioinformatics technology. The company's key product offerings include its Panorama Non-Invasive Prenatal Test (NIPT) which screens for chromosomal abnormalities of a fetus as well as in twin pregnancies, typically with a blood draw from the mother, Horizon Carrier Screening (HCS) to determine carrier status for a large number of severe genetic diseases that could be passed on to the carrier's children, Signatera molecular residual disease (MRD) test, which detects circulating tumor DNA in patients previously diagnosed with cancer to assess molecular residual disease and monitor for recurrence; and Prospera, to assess organ transplant rejection.
59GF Score

Get the complete analysis for HAM:45E

Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€274.40
Price
€179.22
GF Value