Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Alnylam PharmaceuticalsHAM:DUL +0.08%69 Cyclically Adjusted PB Ratio is 22.42 as of Aug. 02, 2026, which is 69% above its 10-year median of 13.24. GuruFocus rates HAM:DUL with a GF Score™ of 69/100 and a GF Value™ of €459.58 (Significantly Undervalued). The stock has 2 warning signs investors should review. Among 697 Biotechnology companies, Alnylam Pharmaceuticals ranks worse than 95.55% on this metric.
The historical rank and industry rank for Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio or its related term are showing as below:
HAM:DUL'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 4.66 Med: 13.24 Max: 49.35
Current: 22.38
During the past years, Alnylam Pharmaceuticals's highest Cyclically Adjusted PB Ratio was 49.35. The lowest was 4.66. And the median was 13.24.
HAM:DUL's Cyclically Adjusted PB Ratio is ranked worse than 95.55% of 697
companies
in the Biotechnology industry
Industry Median: 1.6
vs HAM:DUL: 22.38
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Alnylam Pharmaceuticals's adjusted book value per share data for the three months ended in Jun. 2026 was €8.789. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €7.96 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Alnylam Pharmaceuticals (HAM:DUL) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio Related Terms
Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio Chart
HAM:DUL vs ONC, RVMD, RPRX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Alnylam Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.
Alnylam Pharmaceuticals Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 22.42 mean?
Alnylam Pharmaceuticals (HAM:DUL) has a Cyclically Adjusted PB Ratio of 22.42 as of Aug. 02, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Alnylam Pharmaceuticals and its competitors. This is 69% above median its historical median of 13.24. Over the past decade, Alnylam Pharmaceuticals' Cyclically Adjusted PB Ratio has ranged from 4.66 to 49.35. According to the industry distribution chart, Alnylam Pharmaceuticals ranks #666 out of 697 companies in the Biotechnology industry, placing it in the top 95.6%.
Is Alnylam Pharmaceuticals' Cyclically Adjusted PB Ratio too high?
Alnylam Pharmaceuticals' current Cyclically Adjusted PB Ratio of 22.42 is 69% above median its 10-year median of 13.24. Over the past 10 years, this metric has ranged from a low of 4.66 to a high of 49.35. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.60. Alnylam Pharmaceuticals' value of 22.42 is 1301.3% above this industry median. Based on the distribution chart, Alnylam Pharmaceuticals ranks #666 out of 697 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Alnylam Pharmaceuticals has a GF Score™ of 69/100 and is considered Significantly Undervalued, reflecting its overall financial health beyond just this single metric.
How does Alnylam Pharmaceuticals' Cyclically Adjusted PB Ratio compare to ONC and RVMD?
According to the Biotechnology industry distribution chart, Alnylam Pharmaceuticals ranks #666 out of 697 companies for Cyclically Adjusted PB Ratio. This places Alnylam Pharmaceuticals in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.60. Alnylam Pharmaceuticals' value of 22.42 is 1301.3% above this benchmark. Historically, Alnylam Pharmaceuticals' own Cyclically Adjusted PB Ratio has ranged from 4.66 to 49.35 over the past decade. While the company's 10-year median is 13.24 vs. the industry median of 1.60, Alnylam Pharmaceuticals has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.60, based on 697 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Alnylam Pharmaceuticals's current Cyclically Adjusted PB Ratio of 22.42 is 1301.3% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Alnylam Pharmaceuticals and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.60 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Alnylam Pharmaceuticals's current Cyclically Adjusted PB Ratio is 22.42, which is 69% above median its own 10-year median of 13.24. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Alnylam Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Alnylam Pharmaceuticals (HAM:DUL) is currently considered Significantly Undervalued. The stock's GF Value™ is €459.58, compared to a current price of €178.45 — trading 61.2% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 22.42, which is 69% above median its 10-year median of 13.24 and 1301.3% above the Biotechnology industry median of 1.60. Alnylam Pharmaceuticals' overall GF Score™ is 69/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Alnylam Pharmaceuticals (HAM:DUL), the current Cyclically Adjusted PB Ratio is 22.42 as of Aug. 02, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Alnylam Pharmaceuticals (HAM:DUL) Overvalued in 2026?
Based on GuruFocus' analysis, Alnylam Pharmaceuticals stock appears to be undervalued.
The current stock price of €178.45 is trading 61.2% below its estimated GF Value™ of €459.58.
GuruFocus considers Alnylam Pharmaceuticals to be Significantly Undervalued.
Key valuation signals for HAM:DUL:
Cyclically Adjusted PB Ratio: 22.42 (69% above median its 10-year median of 13.24)
GF Value™: €459.58 vs. price of €178.45 (61.2% below fair value)
Industry Position: 1301.3% above the Biotechnology median (#666 of 697)
No single metric tells the full story. See the HAM:DUL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam's commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam's partners, Novartis and Sanofi, respectively. It also has several clinical programs across various therapeutic areas, including cardio-metabolic diseases, neuroscience, and hematology.
69GF Score
Get the complete analysis for HAM:DUL
Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
HAM:DUL has been successfully added to your 
