Lakefront Biotherapeutics NV (MEX:GLPGN) Cyclically Adjusted PB Ratio: 0.65 (As of Aug. 09, 2026) — 47% Below Median

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MEX:GLPGN Lakefront Biotherapeutics NV MEX:GLPGN
58 GF Score
Price MXN665.65
GF Value MXN3,143.44
! 4 Warning Signs
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What is Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio?

Lakefront Biotherapeutics NV MEX:GLPGN 58 Cyclically Adjusted PB Ratio is 0.65 as of Aug. 09, 2026, which is 47% below its 10-year median of 1.22. GuruFocus rates MEX:GLPGN with a GF Score™ of 58/100 and a GF Value™ of MXN3,143.44. The stock has 4 warning signs investors should review. Among 693 Biotechnology companies, Lakefront Biotherapeutics NV ranks better than 72.29% on this metric.

As of today (2026-08-09), Lakefront Biotherapeutics NV's current share price is MXN665.65. Lakefront Biotherapeutics NV's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 was MXN1,021.10. Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio for today is 0.65.

The historical rank and industry rank for Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio or its related term are showing as below:

MEX:GLPGN' s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.58   Med: 1.22   Max: 11.89
Current: 0.58

During the past years, Lakefront Biotherapeutics NV's highest Cyclically Adjusted PB Ratio was 11.89. The lowest was 0.58. And the median was 1.22.

MEX:GLPGN's Cyclically Adjusted PB Ratio is ranked better than
72.29% of 693 companies
in the Biotechnology industry
Industry Median: 1.62 vs MEX:GLPGN: 0.58

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

Lakefront Biotherapeutics NV's adjusted book value per share data for the three months ended in Mar. 2026 was MXN1,029.230. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is MXN1,021.10 for the trailing ten years ended in Mar. 2026.

Shiller PE for Stocks: The True Measure of Stock Valuation


Lakefront Biotherapeutics NV  (MEX:GLPGN) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.


Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio Related Terms


Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio Chart

Lakefront Biotherapeutics NV Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 2.26 1.49 1.16 0.74 0.72

Lakefront Biotherapeutics NV Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.63 0.64 0.77 0.72 0.65

MEX:GLPGN vs VRTX, REGN, RVMD: Cyclically Adjusted PB Ratio Comparison

For the Biotechnology subindustry, Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio falls into.


MEX:GLPGN
58GF Score
Lakefront Biotherapeutics NV MEX:GLPGN
Cyclically Adjusted PB Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Lakefront Biotherapeutics NV Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio for today is calculated as

Cyclically Adjusted PB Ratio=Share Price/ Cyclically Adjusted Book per Share
=665.65/1021.10
=0.65

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lakefront Biotherapeutics NV's Cyclically Adjusted Book per Share for the quarter that ended in Mar. 2026 is calculated as:

For example, Lakefront Biotherapeutics NV's adjusted Book Value per Share data for the three months ended in Mar. 2026 was:

Adj_Book=Book Value per Share/CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=1029.23/136.5600*136.5600
=1,029.230

Current CPI (Mar. 2026) = 136.5600.

Lakefront Biotherapeutics NV Quarterly Data

Book Value per Share CPI Adj_Book
201606 328.880 102.267 439.163
201609 332.542 102.118 444.699
201612 356.714 102.614 474.720
201703 325.714 103.972 427.804
201706 426.831 103.902 560.989
201709 0.000 104.170 0.000
201712 461.758 104.804 601.672
201803 393.221 105.419 509.381
201806 396.009 106.063 509.877
201809 477.620 106.618 611.753
201812 498.003 107.252 634.088
201903 471.866 107.876 597.332
201906 452.670 107.896 572.927
201909 889.738 107.470 1,130.571
201912 931.867 108.065 1,177.589
202003 1,135.219 108.550 1,428.144
202006 1,104.688 108.540 1,389.862
202009 1,080.003 108.441 1,360.046
202012 987.912 108.511 1,243.281
202103 1,003.462 109.522 1,251.194
202106 974.901 110.305 1,206.954
202109 966.214 111.543 1,182.914
202112 934.698 114.705 1,112.790
202203 884.041 118.620 1,017.747
202206 856.394 120.948 966.934
202209 813.850 124.120 895.420
202212 792.406 126.578 854.898
202303 751.075 126.528 810.625
202306 728.326 125.973 789.535
202309 739.563 127.083 794.714
202312 785.281 128.292 835.888
202403 792.513 130.552 828.986
202406 870.931 130.691 910.046
202409 949.332 130.968 989.866
202412 960.053 132.346 990.625
202503 922.274 134.348 937.462
202506 871.322 133.495 891.326
202509 799.505 133.740 816.363
202512 1,035.326 135.070 1,046.747
202603 1,029.230 136.560 1,029.230

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

What does a Cyclically Adjusted PB Ratio of 0.65 mean?
Lakefront Biotherapeutics NV (MEX:GLPGN) has a Cyclically Adjusted PB Ratio of 0.65 as of Aug. 09, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Lakefront Biotherapeutics NV and its competitors. This is 47% below median its historical median of 1.22. Over the past decade, Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio has ranged from 0.58 to 11.89. According to the industry distribution chart, Lakefront Biotherapeutics NV ranks #192 out of 693 companies in the Biotechnology industry, placing it in the top 27.7%.
Is Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio too high?
Lakefront Biotherapeutics NV's current Cyclically Adjusted PB Ratio of 0.65 is 47% below median its 10-year median of 1.22. Over the past 10 years, this metric has ranged from a low of 0.58 to a high of 11.89. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.62. Lakefront Biotherapeutics NV's value of 0.65 is 59.9% below this industry median. Based on the distribution chart, Lakefront Biotherapeutics NV ranks #192 out of 693 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Lakefront Biotherapeutics NV has a GF Score™ of 58/100, reflecting its overall financial health beyond just this single metric.
How does Lakefront Biotherapeutics NV's Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Lakefront Biotherapeutics NV ranks #192 out of 693 companies for Cyclically Adjusted PB Ratio. This puts Lakefront Biotherapeutics NV in the upper half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.62. Lakefront Biotherapeutics NV's value of 0.65 is 59.9% below this benchmark. Historically, Lakefront Biotherapeutics NV's own Cyclically Adjusted PB Ratio has ranged from 0.58 to 11.89 over the past decade. While the company's 10-year median is 1.22 vs. the industry median of 1.62, Lakefront Biotherapeutics NV has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.62, based on 693 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Lakefront Biotherapeutics NV's current Cyclically Adjusted PB Ratio of 0.65 is 59.9% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Lakefront Biotherapeutics NV and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.62 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Lakefront Biotherapeutics NV's current Cyclically Adjusted PB Ratio is 0.65, which is 47% below median its own 10-year median of 1.22. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lakefront Biotherapeutics NV stock overvalued right now?
Lakefront Biotherapeutics NV (MEX:GLPGN) has a current Cyclically Adjusted PB Ratio of 0.65. The stock's GF Value™ is MXN3,143.44, compared to a current price of MXN665.65 — trading 78.8% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.65, which is 47% below median its 10-year median of 1.22 and 59.9% below the Biotechnology industry median of 1.62. Lakefront Biotherapeutics NV's overall GF Score™ is 58/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Lakefront Biotherapeutics NV (MEX:GLPGN), the current Cyclically Adjusted PB Ratio is 0.65 as of Aug. 09, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Lakefront Biotherapeutics NV (MEX:GLPGN) Overvalued in 2026?

Based on GuruFocus' analysis, Lakefront Biotherapeutics NV stock appears to be undervalued. The current stock price of MXN665.65 is trading 78.8% below its estimated GF Value™ of MXN3,143.44.

Key valuation signals for MEX:GLPGN:

  • Cyclically Adjusted PB Ratio: 0.65 (47% below median its 10-year median of 1.22)
  • GF Value™: MXN3,143.44 vs. price of MXN665.65 (78.8% below fair value)
  • GF Score™: 58/100 with 4 warning signs
  • Industry Position: 59.9% below the Biotechnology median (#192 of 693)

No single metric tells the full story. See the MEX:GLPGN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Lakefront Biotherapeutics NV Business Description

Address Schalienhoevedreef 20 T, Mechelen, BEL, 2800
Lakefront Biotherapeutics NV a biopharmaceutical company committed to improving the lives of people with severe diseases. It focuses on delivering medicines with transformational impact for patients by accelerating life-changing science and innovation in areas of high unmet need. Its pipelines includes GLPG3667, GLPG5101, and GLPG5301.
58GF Score

Get the complete analysis for MEX:GLPGN

Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN665.65
Price
MXN3,143.44
GF Value