Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Japan Tissue Engineering CoTSE:7774 +2.89%56 Cyclically Adjusted PB Ratio is 4.35 as of Aug. 08, 2026, which is 20% above its 10-year median of 3.63. GuruFocus rates TSE:7774 with a GF Score™ of 56/100 and a GF Value™ of 円504.66 (Significantly Overvalued). The stock has 4 warning signs investors should review. Among 697 Biotechnology companies, Japan Tissue Engineering Co ranks worse than 70.3% on this metric.
The historical rank and industry rank for Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio or its related term are showing as below:
TSE:7774'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 2.13 Med: 3.63 Max: 13.41
Current: 4.35
During the past years, Japan Tissue Engineering Co's highest Cyclically Adjusted PB Ratio was 13.41. The lowest was 2.13. And the median was 3.63.
TSE:7774's Cyclically Adjusted PB Ratio is ranked worse than 70.3% of 697
companies
in the Biotechnology industry
Industry Median: 1.6
vs TSE:7774: 4.35
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Japan Tissue Engineering Co's adjusted book value per share data for the three months ended in Mar. 2026 was 円125.346. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円188.68 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Japan Tissue Engineering Co (TSE:7774) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Japan Tissue Engineering Co Cyclically Adjusted PB Ratio Related Terms
Japan Tissue Engineering Co Cyclically Adjusted PB Ratio Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Japan Tissue Engineering Co Cyclically Adjusted PB Ratio Chart
TSE:7774 vs VRTX, REGN, RVMD: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Japan Tissue Engineering Co Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio falls into.
Japan Tissue Engineering Co Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 4.35 mean?
Japan Tissue Engineering Co (TSE:7774) has a Cyclically Adjusted PB Ratio of 4.35 as of Aug. 08, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Japan Tissue Engineering Co and its competitors. This is 20% above median its historical median of 3.63. Over the past decade, Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio has ranged from 2.13 to 13.41. According to the industry distribution chart, Japan Tissue Engineering Co ranks #490 out of 697 companies in the Biotechnology industry, placing it in the top 70.3%.
Is Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio too high?
Japan Tissue Engineering Co's current Cyclically Adjusted PB Ratio of 4.35 is 20% above median its 10-year median of 3.63. Over the past 10 years, this metric has ranged from a low of 2.13 to a high of 13.41. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.60. Japan Tissue Engineering Co's value of 4.35 is 171.9% above this industry median. Based on the distribution chart, Japan Tissue Engineering Co ranks #490 out of 697 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Japan Tissue Engineering Co has a GF Score™ of 56/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Japan Tissue Engineering Co's Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Japan Tissue Engineering Co ranks #490 out of 697 companies for Cyclically Adjusted PB Ratio. This places Japan Tissue Engineering Co in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.60. Japan Tissue Engineering Co's value of 4.35 is 171.9% above this benchmark. Historically, Japan Tissue Engineering Co's own Cyclically Adjusted PB Ratio has ranged from 2.13 to 13.41 over the past decade. While the company's 10-year median is 3.63 vs. the industry median of 1.60, Japan Tissue Engineering Co has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.60, based on 697 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Japan Tissue Engineering Co's current Cyclically Adjusted PB Ratio of 4.35 is 171.9% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Japan Tissue Engineering Co and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.60 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Japan Tissue Engineering Co's current Cyclically Adjusted PB Ratio is 4.35, which is 20% above median its own 10-year median of 3.63. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Japan Tissue Engineering Co stock overvalued right now?
Based on GuruFocus' analysis, Japan Tissue Engineering Co (TSE:7774) is currently considered Significantly Overvalued. The stock's GF Value™ is 円504.66, compared to a current price of 円820.00 — trading 62.5% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 4.35, which is 20% above median its 10-year median of 3.63 and 171.9% above the Biotechnology industry median of 1.60. Japan Tissue Engineering Co's overall GF Score™ is 56/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Japan Tissue Engineering Co (TSE:7774), the current Cyclically Adjusted PB Ratio is 4.35 as of Aug. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Japan Tissue Engineering Co (TSE:7774) Overvalued in 2026?
Based on GuruFocus' analysis, Japan Tissue Engineering Co stock appears to be overvalued.
The current stock price of 円820.00 is trading 62.5% above its estimated GF Value™ of 円504.66.
GuruFocus considers Japan Tissue Engineering Co to be Significantly Overvalued.
Key valuation signals for TSE:7774:
Cyclically Adjusted PB Ratio: 4.35 (20% above median its 10-year median of 3.63)
GF Value™: 円504.66 vs. price of 円820.00 (62.5% above fair value)
Industry Position: 171.9% above the Biotechnology median (#490 of 697)
No single metric tells the full story. See the TSE:7774 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Japan Tissue Engineering Co Ltd is a bio-venture enterprise. It is engaged in the development, manufacture, and sale of tissue-engineered medical products and related products. It operates through the Regenerative Medicine, and Research and Development support business segments. The main business goal is to use autologous culturing techniques to develop tissue-engineered medical products and then to manufacture and sell these same tissue-engineered products to medical institutions for medical treatment. The company's tissue-engineered medical products are used in autologous transplant cases, where living cells are taken from the actual patient himself, cultured and then transplanted back to that same patient.
56GF Score
Get the complete analysis for TSE:7774
Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
TSE:7774 has been successfully added to your 
