IlluminaXSWX:ILMN -0.79%76 Cyclically Adjusted PB Ratio is 5.08 as of Jun. 27, 2026, which is 69% below its 10-year median of 16.26. GuruFocus rates XSWX:ILMN with a GF Score™ of 76/100 and a GF Value™ of CHF105.51. The stock has 7 warning signs investors should review. Among 134 Medical Diagnostics & Research companies, Illumina ranks worse than 80.6% on this metric.
The historical rank and industry rank for Illumina's Cyclically Adjusted PB Ratio or its related term are showing as below:
XSWX:ILMN'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 2.06 Med: 16.26 Max: 28.82
Current: 5
During the past years, Illumina's highest Cyclically Adjusted PB Ratio was 28.82. The lowest was 2.06. And the median was 16.26.
XSWX:ILMN's Cyclically Adjusted PB Ratio is ranked worse than 80.6% of 134
companies
in the Medical Diagnostics & Research industry
Industry Median: 1.885
vs XSWX:ILMN: 5.00
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Illumina's adjusted book value per share data for the three months ended in Mar. 2026 was CHF13.861. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is CHF28.31 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Illumina (XSWX:ILMN) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Illumina Cyclically Adjusted PB Ratio Related Terms
Illumina Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Illumina's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
XSWX:ILMN vs MTD, DGX, LH: Cyclically Adjusted PB Ratio Comparison
For the Diagnostics & Research subindustry, Illumina's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Illumina Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Illumina's Cyclically Adjusted PB Ratio falls into.
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Illumina's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 5.08 mean?
Illumina (XSWX:ILMN) has a Cyclically Adjusted PB Ratio of 5.08 as of Jun. 27, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Illumina and its competitors. This is 69% below median its historical median of 16.26. Over the past decade, Illumina's Cyclically Adjusted PB Ratio has ranged from 2.06 to 28.82. According to the industry distribution chart, Illumina ranks #108 out of 134 companies in the Medical Diagnostics & Research industry, placing it in the top 80.6%.
Is Illumina's Cyclically Adjusted PB Ratio too high?
Illumina's current Cyclically Adjusted PB Ratio of 5.08 is 69% below median its 10-year median of 16.26. Over the past 10 years, this metric has ranged from a low of 2.06 to a high of 28.82. The Medical Diagnostics & Research industry median Cyclically Adjusted PB Ratio is 1.89. Illumina's value of 5.08 is 169.5% above this industry median. Based on the distribution chart, Illumina ranks #108 out of 134 companies in the Medical Diagnostics & Research industry, which is in the bottom quartile relative to peers. Overall, Illumina has a GF Score™ of 76/100, reflecting its overall financial health beyond just this single metric.
How does Illumina's Cyclically Adjusted PB Ratio compare to MTD and DGX?
According to the Medical Diagnostics & Research industry distribution chart, Illumina ranks #108 out of 134 companies for Cyclically Adjusted PB Ratio. This places Illumina in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.89. Illumina's value of 5.08 is 169.5% above this benchmark. Historically, Illumina's own Cyclically Adjusted PB Ratio has ranged from 2.06 to 28.82 over the past decade. While the company's 10-year median is 16.26 vs. the industry median of 1.89, Illumina has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Medical Diagnostics & Research company?
The median Cyclically Adjusted PB Ratio among Medical Diagnostics & Research companies is 1.89, based on 134 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Illumina's current Cyclically Adjusted PB Ratio of 5.08 is 169.5% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Illumina and its competitors. For the Medical Diagnostics & Research industry, the median Cyclically Adjusted PB Ratio is 1.89 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Illumina's current Cyclically Adjusted PB Ratio is 5.08, which is 69% below median its own 10-year median of 16.26. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Illumina stock overvalued right now?
Illumina (XSWX:ILMN) has a current Cyclically Adjusted PB Ratio of 5.08. The stock's GF Value™ is CHF105.51, compared to a current price of CHF143.95 — trading 36.4% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 5.08, which is 69% below median its 10-year median of 16.26 and 169.5% above the Medical Diagnostics & Research industry median of 1.89. Illumina's overall GF Score™ is 76/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Illumina (XSWX:ILMN), the current Cyclically Adjusted PB Ratio is 5.08 as of Jun. 27, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Illumina (XSWX:ILMN) Overvalued in 2026?
Based on GuruFocus' analysis, Illumina stock appears to be overvalued.
The current stock price of CHF143.95 is trading 36.4% above its estimated GF Value™ of CHF105.51.
Key valuation signals for XSWX:ILMN:
Cyclically Adjusted PB Ratio: 5.08 (69% below median its 10-year median of 16.26)
GF Value™: CHF105.51 vs. price of CHF143.95 (36.4% above fair value)
Industry Position: 169.5% above the Medical Diagnostics & Research median (#108 of 134)
No single metric tells the full story. See the XSWX:ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
76GF Score
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