3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Illumina's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -4.82%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Illumina's 3-Year ROIIC % or its related term are showing as below:
XSWX:ILMN's 3-Year ROIIC % is ranked worse than 59.31% of 204
companies
in the Medical Diagnostics & Research industry
Industry Median: 0.685
vs XSWX:ILMN: -4.82
Illumina (XSWX:ILMN) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Illumina 3-Year ROIIC % Related Terms
Illumina 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Illumina's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
XSWX:ILMN vs MTD, DGX, LH: 3-Year ROIIC % Comparison
For the Diagnostics & Research subindustry, Illumina's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Illumina 3-Year ROIIC % vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Illumina's 3-Year ROIIC % falls into.
Illumina's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( 509.5901409 (Dec. 2025) - 329.786 (Dec. 2022) )
/
( 3603.582 (Dec. 2025) - 9733.356 (Dec. 2022) )
=
179.8041409
/
-6129.774
=
-2.93%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Illumina (XSWX:ILMN) has a 3-Year ROIIC % of -4.82 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Illumina and its competitors. According to the industry distribution chart, Illumina ranks #121 out of 204 companies in the Medical Diagnostics & Research industry, placing it in the top 59.3%.
Is Illumina's 3-Year ROIIC % too high?
Illumina's current 3-Year ROIIC % is -4.82. Based on the distribution chart, Illumina ranks #121 out of 204 companies in the Medical Diagnostics & Research industry, which is below the industry midpoint. Overall, Illumina has a GF Score™ of 76/100, reflecting its overall financial health beyond just this single metric.
How does Illumina's 3-Year ROIIC % compare to MTD and DGX?
According to the Medical Diagnostics & Research industry distribution chart, Illumina ranks #121 out of 204 companies for 3-Year ROIIC %. This places Illumina in the lower half of its industry. The industry median 3-Year ROIIC % is 0.69. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Medical Diagnostics & Research company?
The median 3-Year ROIIC % among Medical Diagnostics & Research companies is 0.69, based on 204 companies in the industry. Companies in the top quartile (top 25%) have a 3-Year ROIIC % significantly above this median, while those in the bottom quartile fall well below. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Illumina and its competitors. For the Medical Diagnostics & Research industry, the median 3-Year ROIIC % is 0.69 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Illumina's current 3-Year ROIIC % is -4.82. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Illumina stock overvalued right now?
Illumina (XSWX:ILMN) has a current 3-Year ROIIC % of -4.82. The stock's GF Value™ is CHF105.51, compared to a current price of CHF143.95 — trading 36.4% above its estimated fair value. The current 3-Year ROIIC % is -4.82. Illumina's overall GF Score™ is 76/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Illumina (XSWX:ILMN), the current 3-Year ROIIC % is -4.82 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Illumina (XSWX:ILMN) Overvalued in 2026?
Based on GuruFocus' analysis, Illumina stock appears to be overvalued.
The current stock price of CHF143.95 is trading 36.4% above its estimated GF Value™ of CHF105.51.
Key valuation signals for XSWX:ILMN:
3-Year ROIIC %: -4.82
GF Value™: CHF105.51 vs. price of CHF143.95 (36.4% above fair value)
No single metric tells the full story. See the XSWX:ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
76GF Score
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