Illumina (XTER:ILU) Cyclically Adjusted PB Ratio: (As of Aug. 05, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
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Charlie Tian
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Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

XTER:ILU Illumina Inc XTER:ILU
72 GF Score
Price €171.92
GF Value €117.64
Valuation Significantly Overvalued
! 7 Warning Signs
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What is Illumina Cyclically Adjusted PB Ratio?

Note: If the price history is too short, we do not calculate current Cyclically Adjusted PB Ratio for this stock. All the historical data is shown as the company's primary share's data instead.

Shiller PE for Stocks: The True Measure of Stock Valuation


Illumina  (XTER:ILU) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.


Illumina Cyclically Adjusted PB Ratio Related Terms


Illumina Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for Illumina's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Illumina Cyclically Adjusted PB Ratio Chart

Illumina Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 15.86 6.75 4.15 3.92 3.76

Illumina Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 2.75 2.72 3.76 3.47 4.90

XTER:ILU vs MTD, DGX, LH: Cyclically Adjusted PB Ratio Comparison

For the Diagnostics & Research subindustry, Illumina's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Illumina Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Illumina's Cyclically Adjusted PB Ratio falls into.


XTER:ILU
72GF Score
Illumina Inc XTER:ILU
Cyclically Adjusted PB Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Illumina Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

Illumina's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 is calculated as:

For example, Illumina's adjusted Book Value per Share data for the three months ended in Jun. 2026 was:

Adj_Book=Book Value per Share/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=16.314/333.9520*333.9520
=16.314

Current CPI (Jun. 2026) = 333.9520.

Illumina Quarterly Data

Book Value per Share CPI Adj_Book
201609 13.587 241.428 18.794
201612 14.246 241.432 19.705
201703 16.336 243.801 22.377
201706 16.550 244.955 22.563
201709 16.406 246.819 22.198
201712 15.802 246.524 21.406
201803 16.624 249.554 22.246
201806 18.966 251.989 25.135
201809 20.422 252.439 27.016
201812 22.471 251.233 29.870
201903 23.991 254.202 31.518
201906 25.904 256.143 33.773
201909 27.419 256.759 35.662
201912 28.243 256.974 36.703
202003 28.535 258.115 36.919
202006 27.753 257.797 35.951
202009 27.331 260.280 35.067
202012 26.428 260.474 33.883
202103 28.318 264.877 35.703
202106 29.248 271.696 35.950
202109 57.351 274.310 69.821
202112 60.541 278.802 72.517
202203 63.011 287.504 73.191
202206 62.930 296.311 70.924
202209 43.301 296.808 48.720
202212 39.427 296.797 44.363
202303 39.565 301.836 43.775
202306 38.293 305.109 41.913
202309 34.801 307.789 37.759
202312 33.133 306.746 36.072
202403 33.178 312.332 35.475
202406 8.374 314.175 8.901
202409 12.118 315.301 12.835
202412 14.253 315.605 15.082
202503 13.776 319.799 14.386
202506 12.712 322.561 13.161
202509 13.259 324.800 13.633
202512 15.199 324.054 15.663
202603 15.229 330.213 15.401
202606 16.314 333.952 16.314

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is Illumina (XTER:ILU) Overvalued in 2026?

Based on GuruFocus' analysis, Illumina stock appears to be overvalued. The current stock price of €171.92 is trading 46.1% above its estimated GF Value™ of €117.64. GuruFocus considers Illumina to be Significantly Overvalued.

Key valuation signals for XTER:ILU:

  • Cyclically Adjusted PB Ratio:
  • GF Value™: €117.64 vs. price of €171.92 (46.1% above fair value)
  • GF Score™: 72/100 with 7 warning signs

No single metric tells the full story. See the XTER:ILU stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Illumina Business Description

Address 5200 Illumina Way, San Diego, CA, USA, 92122
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
72GF Score

Get the complete analysis for XTER:ILU

Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€171.92
Price
€117.64
GF Value